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TCORS 2.0

Effects of Sweet and Coolant Flavors on Nicotine Choice, Consumption and Seeking

The goal of this study is to examine the role of early flavorant and sweetener associations on initiation and persistence of nicotine and flavored tobacco product use and to examine the effects of synthetic cooling agents on the aversive effects of nicotine and tobacco and use behaviors.

Research Team

  • Albert E. Kent Associate Professor of Psychiatry and Associate Professor of Cellular and Molecular Physiology; Director of Scientist Diversity and Inclusion, YSM Office of Diversity, Equity and Inclusion

  • Associate Professor of Anesthesiology, Pharmacology & Cancer Biology, University Program of Environmental Health (UPEH), Duke University School of Medicine

  • Charles B. G. Murphy Professor of Psychiatry and Professor in the Child Study Center, of Neuroscience and of Pharmacology; Director Division of Molecular Psychiatry, Psychiatry; Deputy Chair for Basic Science Research, Dept. of Psychiatry; Director, Interdepartmental Neuroscience Program

Sweet and Cooling Flavors and Nicotine: Examinations in New and Established Tobacco Product Users

The goal of this study is to determine the influence of the “aroma and taste” and “ameliorating” attributes of popular sweet and cooling flavors on the appeal of nicotine-containing e-cigarettes among susceptible youth and to determine the influence of sweet and cool flavors on the abuse potential and use of nicotine-containing e-cigarettes among young adult and older cigarette smokers.

Research Team

Nicotine Delivery Rate and Its Abuse Potential and the Impact of Menthol

The goal of this study is to determine the optimal nicotine delivery rates needed to maintain nicotine abuse potential and reward (using an established IV nicotine infusion paradigm) and to examine the role of menthol cigarette use, and switching to non-menthol cigarette use, on these outcomes.

Research Team