Featured Publications
Reinforcement learning detuned in addiction: integrative and translational approaches
Groman SM, Thompson SL, Lee D, Taylor JR. Reinforcement learning detuned in addiction: integrative and translational approaches. Trends In Neurosciences 2021, 45: 96-105. PMID: 34920884, PMCID: PMC8770604, DOI: 10.1016/j.tins.2021.11.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDecision-making deficitsPathophysiology of addictionDecision-making strategiesBiobehavioral mechanismsAddictionReinforcement learningDecision-making processDrug useTranslational approachComputational componentsDeficitsLearningDifferent componentsBiological mechanismsOutcomesFindingsRecent studiesBehaviorStudy
2022
Targeted effects of ketamine on perceptual expectation during mediated learning in rats
Fleming LM, Jaynes FB, Thompson SL, Corlett PR, Taylor JR. Targeted effects of ketamine on perceptual expectation during mediated learning in rats. Psychopharmacology 2022, 239: 2395-2405. PMID: 35389087, PMCID: PMC9296571, DOI: 10.1007/s00213-022-06128-2.Peer-Reviewed Original ResearchConceptsPerceptual expectationsHallucination-like experiencesMemory representationsExpected cueDevaluation phasePerceptual experienceNeural correlatesAssociative learningLearning taskTask phasesExternal outcomesDirect learningLearningEffects of ketamineExpectationsRetrievalConclusionsThese resultsModerate dosePerceptCausal relationshipCuesExperienceRepresentationTaskRecent work
2009
Cone photoreceptor mosaic disruption associated with Cys203Arg mutation in the M-cone opsin
Carroll J, Baraas RC, Wagner-Schuman M, Rha J, Siebe CA, Sloan C, Tait DM, Thompson S, Morgan JI, Neitz J, Williams DR, Foster DH, Neitz M. Cone photoreceptor mosaic disruption associated with Cys203Arg mutation in the M-cone opsin. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 20948-20953. PMID: 19934058, PMCID: PMC2791574, DOI: 10.1073/pnas.0910128106.Peer-Reviewed Original ResearchConceptsEarly-onset retinitis pigmentosaOuter nuclear layerM-cone opsinCone opsin mutationsColor vision defectsVision lossCommon causeNuclear layerCone functionRetinitis pigmentosaCone densityVision defectsMosaic disruptionSubstitution of arginineFrequent mutationsColor vision deficiencyCone opsinsGreen color vision defectsSignificant reduction