Featured Publications
Ketogenic diet enhances the effects of oxycodone in mice
Trinko R, Diaz D, Foscue E, Thompson S, Taylor J, DiLeone R. Ketogenic diet enhances the effects of oxycodone in mice. Scientific Reports 2023, 13: 7507. PMID: 37160959, PMCID: PMC10170077, DOI: 10.1038/s41598-023-33458-8.Peer-Reviewed Original ResearchConceptsOpioid use disorderKetogenic dietKD miceUse disordersTreatment of OUDEffects of KDEffects of oxycodoneClinical pain managementAlcohol use disorderProgressive ratio scheduleSex-specific effectsChronic oxycodoneLess oxycodoneOpioid withdrawalAntinociceptive effectPain managementPrescription opioidsSide effectsOxycodoneLocomotor activityTherapeutic potentialOpioidsDietary effectsOpiate sensitivityMiceKetamine induces immediate and delayed alterations of OCD-like behavior
Thompson SL, Welch AC, Iourinets J, Dulawa SC. Ketamine induces immediate and delayed alterations of OCD-like behavior. Psychopharmacology 2020, 237: 627-638. PMID: 31927606, DOI: 10.1007/s00213-019-05397-8.Peer-Reviewed Original ResearchConceptsOCD-like behaviorPrepulse inhibitionTherapeutic effectH postinjectionNoncompetitive NMDA receptor antagonistOCD patientsAnti-OCD effectsRationaleObsessive-compulsive disorderNMDA receptor antagonistRapid therapeutic effectPretreatment time pointsAcute ketaminePharmacological monotherapyKetamine pretreatmentKetamine treatmentPPI deficitsReuptake inhibitorsReceptor antagonistLow doseMin postinjectionPsychiatric disordersDelayed alterationsResponse rateHigh dosesKetamineBtbd3 expression regulates compulsive-like and exploratory behaviors in mice
Thompson SL, Welch AC, Ho EV, Bessa JM, Portugal-Nunes C, Morais M, Young JW, Knowles JA, Dulawa SC. Btbd3 expression regulates compulsive-like and exploratory behaviors in mice. Translational Psychiatry 2019, 9: 222. PMID: 31501410, PMCID: PMC6733800, DOI: 10.1038/s41398-019-0558-7.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderKnockout miceCompulsive-like behaviorLimbic cortico-striatoExploratory behaviorThalamo-cortical circuitsMarble-burying testPrimary sensory cortexNeural circuit formationDendritic morphologyImpaired goal-directed behaviorAnterior cingulate cortexGoal-directed behaviorChronic treatmentSpine densityCortico-striatoMediodorsal thalamusDendritic pruningSensory cortexNeonatal developmentAnterior cingulateCingulate cortexCircuit formationPotential risk genesMiceDissecting the roles of β-arrestin2 and GSK-3 signaling in 5-HT1BR-mediated perseverative behavior and prepulse inhibition deficits in mice
Thompson SL, Dulawa SC. Dissecting the roles of β-arrestin2 and GSK-3 signaling in 5-HT1BR-mediated perseverative behavior and prepulse inhibition deficits in mice. PLOS ONE 2019, 14: e0211239. PMID: 30721232, PMCID: PMC6363181, DOI: 10.1371/journal.pone.0211239.Peer-Reviewed Original ResearchConceptsPPI deficitsObsessive-compulsive disorderGSK-3 inhibitionΒ-arrestin2Perseverative behaviorInhibitory G protein-coupled receptorsGSK-3 inhibitorsPerseverative locomotor patternsG protein-coupled pathwaySerotonin 1B receptorG protein-coupled receptorsAcute pretreatmentAutism spectrum disorderAcute treatmentKO miceReceptor agonistOpen fieldKnockout miceBehavioral testingBiased ligandsReduced locomotionMiceGSK-3βInhibition deficitsModest reduction
2023
Mice lacking Ptprd exhibit deficits in goal-directed behavior and female-specific impairments in sensorimotor gating
Ho E, Welch A, Thompson S, Knowles J, Dulawa S. Mice lacking Ptprd exhibit deficits in goal-directed behavior and female-specific impairments in sensorimotor gating. PLOS ONE 2023, 18: e0277446. PMID: 37205689, PMCID: PMC10198499, DOI: 10.1371/journal.pone.0277446.Peer-Reviewed Original ResearchConceptsProtein tyrosine phosphatase receptor type DGenome-wide association studiesProtein tyrosine phosphatase familyTyrosine phosphatase familyReceptor type DPhosphatase familyAssociation studiesGenetic studiesCell adhesionPTPRDNest-building behaviorEffect of genotypeSynaptic specificationNeuropsychiatric phenotypesTraitsConstitutive lackKnockout miceKO miceGatingLociBuilding behaviorMicePhenotype
2019
Endocannabinoid contributions to alcohol habits and motivation: Relevance to treatment
Gianessi CA, Groman SM, Thompson SL, Jiang M, van der Stelt M, Taylor JR. Endocannabinoid contributions to alcohol habits and motivation: Relevance to treatment. Addiction Biology 2019, 25: e12768. PMID: 31056846, PMCID: PMC7790504, DOI: 10.1111/adb.12768.Peer-Reviewed Original Research
2018
When tractography meets tracer injections: a systematic study of trends and variation sources of diffusion-based connectivity
Aydogan DB, Jacobs R, Dulawa S, Thompson SL, Francois MC, Toga AW, Dong H, Knowles JA, Shi Y. When tractography meets tracer injections: a systematic study of trends and variation sources of diffusion-based connectivity. Brain Structure And Function 2018, 223: 2841-2858. PMID: 29663135, PMCID: PMC5997540, DOI: 10.1007/s00429-018-1663-8.Peer-Reviewed Original Research
2015
Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation
Ho EV, Thompson SL, Katzka WR, Sharifi MF, Knowles JA, Dulawa SC. Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation. Psychopharmacology 2015, 233: 57-70. PMID: 26423528, DOI: 10.1007/s00213-015-4086-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCorpus StriatumDesipramineExploratory BehaviorFemaleFluoxetineIndolesMiceMice, Inbred C57BLObsessive-Compulsive DisorderReceptor, Serotonin, 5-HT1BSerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor AntagonistsSerotonin Receptor AgonistsStereotyped BehaviorTreatment OutcomeConceptsAcute treatmentFos expressionDorsal striatumOCD treatmentStriatal activationReceptor agonist treatmentEffective OCD treatmentOpen-field behaviorChronic fluoxetineAgonist treatmentObsessive-compulsive disorderChronic pretreatmentLocomotor stereotypySeparate miceNeuronal activationDrug treatmentTreatment preventsRepetitive behaviorsOCD pathophysiologyBrain regionsOrbitofrontal cortexBehavioral effectsRU24969Inhibition deficitsBrain activation