2005
Synchronized Maternal-Infant Elevations of Primate CSF CRF Concentrations in Response to Variable Foraging Demand
Coplan J, Altemus M, Mathew S, Smith E, Sharf B, Coplan P, Kral J, Gorman J, Owens M, Nemeroff C, Rosenblum L. Synchronized Maternal-Infant Elevations of Primate CSF CRF Concentrations in Response to Variable Foraging Demand. CNS Spectrums 2005, 10: 530-536. PMID: 16155510, DOI: 10.1017/s109285290001018x.Peer-Reviewed Original ResearchConceptsCentral corticotropin-releasing factorCSF CRF concentrationsCRF concentrationsCentral CRF systemCorticotropin-releasing factorSignificant mean increaseCerebrospinal fluid samplesEarly life stressorsVFD conditionsInfant sex differencesEnvironment-gene interactionsCRF levelsCRF expressionPsychiatric disordersCRF responseCRF systemInfant's lifeMean increaseDays postpartumInfantsStudy periodFluid samplesMothersMaternal responsivitySex differences
2004
Puberty, Ovarian Steroids, and Stress
YOUNG E, ALTEMUS M. Puberty, Ovarian Steroids, and Stress. Annals Of The New York Academy Of Sciences 2004, 1021: 124-133. PMID: 15251881, DOI: 10.1196/annals.1308.013.Peer-Reviewed Original ResearchConceptsStressful life eventsMajor depressionDepressed womenPostmenopausal depressed womenReproductive hormonal changesLife eventsNormal progesteronePremenopausal womenCommon etiologyOvarian hormonesOvarian steroidsHPA axisAdrenal axisNormal womenLow estradiolFirst episodeDepressed menHormonal changesBaseline cortisolEstradiolInhibitory feedbackPubertyYoung adulthoodWomenDepression
2002
Differing concentrations of corticotropin-releasing factor and oxytocin in the cerebrospinal fluid of bonnet and pigtail macaques
Rosenblum L, Smith E, Altemus M, Scharf B, Owens M, Nemeroff C, Gorman J, Coplan J. Differing concentrations of corticotropin-releasing factor and oxytocin in the cerebrospinal fluid of bonnet and pigtail macaques. Psychoneuroendocrinology 2002, 27: 651-660. PMID: 12084658, DOI: 10.1016/s0306-4530(01)00056-7.Peer-Reviewed Original Research
2001
Variable foraging demand rearing: sustained elevations in cisternal cerebrospinal fluid corticotropin-releasing factor concentrations in adult primates
Coplan J, Smith E, Altemus M, Scharf B, Owens M, Nemeroff C, Gorman J, Rosenblum L. Variable foraging demand rearing: sustained elevations in cisternal cerebrospinal fluid corticotropin-releasing factor concentrations in adult primates. Biological Psychiatry 2001, 50: 200-204. PMID: 11513819, DOI: 10.1016/s0006-3223(01)01175-1.Peer-Reviewed Original ResearchConceptsCerebrospinal fluid corticotropin-releasing factor concentrationsCorticotropin-releasing factor concentrationsFactor concentrationsCSF CRFAdult primatesYoung adult primatesYoung adulthoodCisternal CSF samplesCSF samplesCRF functionControl groupCRF valuesSignificant positive correlationAd libitumPresent studyJuvenile primatesPositive correlationAdulthoodPrimatesCRFElevationEffects of Estrogen Antagonists and Agonists on the ACTH Response to Restraint Stress in Female Rats
Young E, Altemus M, Parkison V, Shastry S. Effects of Estrogen Antagonists and Agonists on the ACTH Response to Restraint Stress in Female Rats. Neuropsychopharmacology 2001, 25: 881-891. PMID: 11750181, DOI: 10.1016/s0893-133x(01)00301-3.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAnimalsAnti-Inflammatory AgentsCorticosteroneDrug ImplantsEstradiolEstrogen AntagonistsEstrogensFeedbackFemaleGlucocorticoidsHypothalamo-Hypophyseal SystemMaleNitromifeneOvariectomyProgesteroneRatsRats, Sprague-DawleyRestraint, PhysicalStress, PsychologicalTamoxifenConceptsRestraint stressACTH responseCorticosterone responseFemale ratsDays of estradiolLow-dose estradiolExogenous glucocorticoid administrationEstrogen antagonist tamoxifenCombination of estradiolAdrenal stress responseImportant inhibitory factorProgesterone replacementDose estradiolGlucocorticoid administrationEstrogen contributesAntagonist tamoxifenEstrogen antagonistEstradiol treatmentACTHInhibitory factorEstradiolRatsTamoxifenProgesteroneSex differencesChapter 17 Neuroendocrine and emotional changes in the post-partum period
Carter C, Altemus M, Pchrousos G. Chapter 17 Neuroendocrine and emotional changes in the post-partum period. Progress In Brain Research 2001, 133: 241-249. PMID: 11589134, DOI: 10.1016/s0079-6123(01)33018-2.Peer-Reviewed Original ResearchConceptsPost-partum periodCorticotrophin-releasing hormoneAdrenal axisBehavioral effectsAdrenal stress axisCentral behavioral effectsPost-partum womenPowerful regulatory effectsFemale reproductive systemOptimal maternal careBrain levelsHigher bloodImmune systemExperimental animalsActive hormoneCentral mechanismsHormoneMaternal careReproductive systemNeuropeptide hormoneRegulatory effectsMood statesIntegrative functionsNeuropeptidesOxytocin
2000
Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations
Coplan J, Smith E, Trost R, Scharf B, Altemus M, Bjornson L, Owens M, Gorman J, Nemeroff C, Rosenblum L. Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations. Psychiatry Research 2000, 95: 93-102. PMID: 10963795, DOI: 10.1016/s0165-1781(00)00173-6.Peer-Reviewed Original ResearchConceptsCSF CRF concentrationsVariable foraging demandGrowth hormone responseGH responseCRF concentrationsCerebrospinal fluid corticotropin-releasing factor concentrationsHormone responseCorticotropin-releasing factor concentrationsAdult primatesDosage of clonidineYoung adult primatesAdrenergic agonist clonidineCorticotropin-releasing factorAgonist clonidineNeuroendocrine abnormalitiesPersistent elevationPrevious primate studiesGH releaseGH-like immunoreactivitySignificant inverse relationshipKetamine anesthesiaClonidineCRF activityHuman patientsFactor concentrations
1997
Central nervous system actions of oxytocin and modulation of behavior in humans
McCarthy M, Altemus M. Central nervous system actions of oxytocin and modulation of behavior in humans. Trends In Molecular Medicine 1997, 3: 269-275. PMID: 9211418, DOI: 10.1016/s1357-4310(97)01058-7.Peer-Reviewed Original ResearchConceptsCentral nervous system actionsGonadal steroid hormonesPosterior pituitary hormone oxytocinAction of oxytocinPituitary hormone oxytocinModulation of behaviorImportance of oxytocinModulatory effectsNeuropsychiatric disordersSteroid hormonesOxytocinRegulation of behaviorNeural functioningHormone oxytocinOxytocin systemImportant regulatorSystem actionsHumansDysfunctionEstrogenEtiologyIntegrative Functions of Lactational Hormones in Social Behavior and Stress Managementa
CARTER C, ALTEMUS M. Integrative Functions of Lactational Hormones in Social Behavior and Stress Managementa. Annals Of The New York Academy Of Sciences 1997, 807: 164-174. PMID: 9071349, DOI: 10.1111/j.1749-6632.1997.tb51918.x.Peer-Reviewed Original ResearchConceptsPositive social behaviorSocial behaviorMammalian social behaviorMaternal-infant interactionNeuropeptide oxytocinEnhanced arousalSocial attachmentSocial interactionBehavioral studiesPair bondingAggressive behaviorNeurochemical systemsSocial contactIntegrative functionsAnimal researchBehavioral effectsOwn recent findingsLactational hormonesSocial aspectsOxytocinImportant reproductive functionsSexual behaviorAutonomic changesRecent findingsArousal
1996
Effects of serotonergic agents on food-restriction-induced hyperactivity
Altemus M, Glowa J, Galliven E, Leong Y, Murphy D. Effects of serotonergic agents on food-restriction-induced hyperactivity. Pharmacology Biochemistry And Behavior 1996, 53: 123-131. PMID: 8848441, DOI: 10.1016/0091-3057(95)02003-9.Peer-Reviewed Original ResearchConceptsSaline-treated ratsObsessive-compulsive disorderReuptake inhibitorsSerotonin selective reuptake inhibitorsSelective monoamine reuptake inhibitorsSelective reuptake inhibitorsChronic fluoxetine treatmentMonoamine reuptake inhibitorsTryptophan hydroxylase inhibitorCentral serotonergic activityPossible animal modelOCD symptomsFluoxetine treatmentChronic treatmentPharmacological treatmentSerotonergic agentsSerotonergic neurotransmissionSerotonergic activityFood restrictionHydroxylase inhibitorAnimal modelsRunning wheelRatsParachlorophenylalanineAdditional group
1995
Neuropeptides in Anxiety Disorders
ALTEMUS M. Neuropeptides in Anxiety Disorders. Annals Of The New York Academy Of Sciences 1995, 771: 697-707. PMID: 8597442, DOI: 10.1111/j.1749-6632.1995.tb44721.x.Peer-Reviewed Original ResearchSuppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women
Altemus M, Deuster P, Galliven E, Carter C, Gold P. Suppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women. The Journal Of Clinical Endocrinology & Metabolism 1995, 80: 2954-2959. PMID: 7559880, DOI: 10.1210/jcem.80.10.7559880.Peer-Reviewed Original ResearchConceptsNeurohormonal systemsTreadmill exerciseBasal norepinephrine levelsIntensity-dependent activationAdrenal axis responseMin of exerciseMaximal oxygen uptakeSympathomedullary systemNorepinephrine levelsBreast feedingPlasma ACTHAdrenal axisNonlactating womenWeeks postpartumAxis responseGlucose responseWomenPhysical conditioningOxygen uptakeExerciseSubjectsPhysiological responsesResponseACTHPostpartumStress and antidepressants differentially regulate neurotrophin 3 mRNA expression in the locus coeruleus.
Smith M, Makino S, Altemus M, Michelson D, Hong S, Kvetnansky R, Post R. Stress and antidepressants differentially regulate neurotrophin 3 mRNA expression in the locus coeruleus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 8788-8792. PMID: 7568018, PMCID: PMC41052, DOI: 10.1073/pnas.92.19.8788.Peer-Reviewed Original ResearchConceptsNT-3 mRNA levelsLocus coeruleusNT-3MRNA levelsNeurotrophin-3 (NT-3) mRNA expressionSerotonin-specific reuptake inhibitorsNT-3 levelsNT-3 expressionSurvival of neuronsEffects of stressAntidepressant treatmentElectroconvulsive seizuresChronic treatmentLC neuronsNoradrenergic neuronsReuptake inhibitorsNeurotrophin expressionNeurotrophic factorNeurotrophin-3Norepinephrine uptakeImmobilization stressMood disordersLC functionAntidepressantsClinical depression
1994
Increased mRNA for corticotrophin releasing hormone in the amygdala of Fawn‐hooded rats: A potential animal model of anxiety
Altemus M, Smith M, Diep V, Aulakh C, Murphy D. Increased mRNA for corticotrophin releasing hormone in the amygdala of Fawn‐hooded rats: A potential animal model of anxiety. Anxiety 1994, 1: 251-257. PMID: 9160583, DOI: 10.1002/anxi.3070010602.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaAnimalsAnxiety DisordersArousalCorticosteroneCorticotropin-Releasing HormoneDisease Models, AnimalHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemRatsRats, Inbred StrainsRats, WistarReceptors, GlucocorticoidReceptors, MineralocorticoidRNA, MessengerSpecies SpecificityTyrosine 3-MonooxygenaseConceptsFawn-Hooded ratsAdrenal axis activityBasal corticosterone levelsParaventricular nucleusCRH mRNAAdrenal weightAxis activityWistar ratsReceptor mRNACorticosterone levelsArginine vasopressinRat strainsCentral nucleusAdult-onset hypertensionFawn-hooded strainFawn-hooded rat strainMineralocorticoid receptor mRNAUrinary catecholamine levelsHypothalamic paraventricular nucleusGlucocorticoid receptor mRNAWistar rat strainPotential animal modelTyrosine hydroxylase mRNAMore freezing behaviorAVP mRNA expression
1993
Attenuation of food-restriction-induced running by chronic fluoxetine treatment.
Altemus M, Glowa J, Murphy D. Attenuation of food-restriction-induced running by chronic fluoxetine treatment. Psychopharmacology Bulletin 1993, 29: 397-400. PMID: 8121967.Peer-Reviewed Original ResearchConceptsSaline-treated controlsObsessive-compulsive disorderAnimal modelsRunning wheelChronic fluoxetine treatmentPossible animal modelValid animal modelLife-threatening proportionsOCD symptomsAssociated anorexiaFluoxetine treatmentFood restrictionBody weightRatsAntidepressantsWeight lossSignificant attenuationCompulsive runningProgressive increaseAnorexiaFluoxetineDaily accessSymptomsWeeksTreatment
1992
Chronic fluoxetine treatment reduces hypothalamic vasopressin secretion in vitro
Altemus M, Cizza G, Gold P. Chronic fluoxetine treatment reduces hypothalamic vasopressin secretion in vitro. Brain Research 1992, 593: 311-313. PMID: 1450938, DOI: 10.1016/0006-8993(92)91326-a.Peer-Reviewed Original Research