2005
Sex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression
Roca C, Schmidt P, Deuster P, Danaceau M, Altemus M, Putnam K, Chrousos G, Nieman L, Rubinow D. Sex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression. The Journal Of Clinical Endocrinology & Metabolism 2005, 90: 4224-4231. PMID: 15886244, DOI: 10.1210/jc.2004-2525.Peer-Reviewed Original ResearchConceptsSex-related differencesGonadal suppressionReproductive steroid levelsHypogonadal conditionsAdrenal axisSteroid levelsCortisol-binding globulin levelsCRH stimulation testSex differencesHPA axis measuresHPA axis responseMain outcome measuresHPA axis activityMiddle-aged menFemale normal volunteersLeuprolide injectionACTH ratioCRH stimulationOutpatient clinicStimulation testLeuprolide acetateTime of testingAdrenal responsivityAxis activityGlobulin levels
2003
Enhanced Cellular Immune Response in Women With PTSD Related to Childhood Abuse
Altemus M, Cloitre M, Dhabhar F. Enhanced Cellular Immune Response in Women With PTSD Related to Childhood Abuse. American Journal Of Psychiatry 2003, 160: 1705-1707. PMID: 12944352, DOI: 10.1176/appi.ajp.160.9.1705.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderDelayed-type hypersensitivity (DTH) skin test responsesCircadian salivary cortisol levelsHypersensitivity skin test responsesDelayed-type hypersensitivitySkin test responsesCellular immune responsesHPA axis activityCell-mediated inflammatory reactionsHealthy comparison subjectsSalivary cortisol levelsAdrenal axisSympathoadrenomedullary systemAxis activityInflammatory reactionImmune responseImmune functionPsychiatric disordersComparison subjectsCortisol levelsPlasma cortisolHistory of abuseSingle time point measurementStress disorderTime point measurementsDifferential Menstrual Cycle Regulation of Hypothalamic-Pituitary-Adrenal Axis in Women with Premenstrual Syndrome and Controls
Roca C, Schmidt P, Altemus M, Deuster P, Danaceau M, Putnam K, Rubinow D. Differential Menstrual Cycle Regulation of Hypothalamic-Pituitary-Adrenal Axis in Women with Premenstrual Syndrome and Controls. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 3057-3063. PMID: 12843143, DOI: 10.1210/jc.2002-021570.Peer-Reviewed Original ResearchConceptsHPA axis responsePremenstrual syndromeAdrenal axisControl womenMajor depressionLuteal phaseReproductive steroidsAxis responseTreadmill exercise stress testingHPA axis modulationMenstrual cycle regulationHPA axis abnormalitiesExercise stress testingHPA axis regulationStress testingMenstrual cycle phaseAxis abnormalitiesHPA axisMenstrual cycleGonadal steroidsAbnormal responseAxis regulationAffective disordersAffective symptomsPotent modulator
2001
Responses to Laboratory Psychosocial Stress in Postpartum Women
Altemus M, Redwine L, Leong Y, Frye C, Porges S, Carter C. Responses to Laboratory Psychosocial Stress in Postpartum Women. Psychosomatic Medicine 2001, 63: 814-821. PMID: 11573030, DOI: 10.1097/00006842-200109000-00015.Peer-Reviewed Original ResearchConceptsSystolic blood pressureBlood pressurePostpartum womenCardiac vagal toneHeart rateNonlactating womenVagal controlVagal toneParasympathetic nervous system toneHigher systolic blood pressurePsychological stressDiastolic blood pressureEarly follicular phaseHealthy control womenAutonomic nervous systemTrier Social Stress TestAllopregnanolone levelsControl womenAdrenal axisLower cardiac vagal toneFollicular phaseControl subjectsMenstrual cycleSocial Stress TestEffect of lactationStress-Induced Changes in Skin Barrier Function in Healthy Women
Altemus M, Rao B, Dhabhar F, Ding W, Granstein R. Stress-Induced Changes in Skin Barrier Function in Healthy Women. Journal Of Investigative Dermatology 2001, 117: 309-317. PMID: 11511309, DOI: 10.1046/j.1523-1747.2001.01373.x.Peer-Reviewed Original ResearchConceptsNatural killer cell activityKiller cell activityBarrier function recoverySkin barrier functionSkin barrier function recoveryFunction recoveryCell activityInterview stressSleep deprivationTumor necrosisBarrier functionInterleukin-1betaNatural killer cell numbersStress-induced changesPlasma interleukin-1betaHelper T cellsPeripheral blood leukocytesCytolytic T lymphocytesTransepidermal water lossClear exacerbationCytokine responsesHealthy womenInterleukin-10Exercise protocolPlasma levelsAbnormalities in response to vasopressin infusion in chronic fatigue syndrome
Altemus M, Dale J, Michelson D, Demitrack M, Gold P, Straus S. Abnormalities in response to vasopressin infusion in chronic fatigue syndrome. Psychoneuroendocrinology 2001, 26: 175-188. PMID: 11087963, DOI: 10.1016/s0306-4530(00)00044-5.Peer-Reviewed Original ResearchConceptsChronic fatigue syndromeCorticotropin-releasing hormoneHypothalamic CRH secretionFatigue syndromeCRH secretionACTH responseVasopressin infusionCortisol responsePeripheral infusionHour infusionACTH secretionNeuroendocrine abnormalitiesAdrenal axisHypothalamic secretionHypothalamus actsHealthy volunteersPrimary symptomsNeuroendocrine studiesArginine vasopressinInfusionSyndromePatientsSecretionVasopressinAbnormalities
1997
Reduced Sensitivity to Glucocorticoid Feedback and Reduced Glucocorticoid Receptor mRNA Expression in the Luteal Phase of the Menstrual Cycle
Altemus M, Redwine L, Leong Y, Yoshikawa T, Yehuda R, Detera-Wadleigh S, Murphy D. Reduced Sensitivity to Glucocorticoid Feedback and Reduced Glucocorticoid Receptor mRNA Expression in the Luteal Phase of the Menstrual Cycle. Neuropsychopharmacology 1997, 17: 100-109. PMID: 9252985, DOI: 10.1016/s0893-133x(97)00039-0.Peer-Reviewed Original ResearchConceptsMid-luteal phaseGlucocorticoid receptor mRNA expressionReceptor mRNA expressionMenstrual cycleMRNA expressionFollicular phaseCommon premenstrual symptomsGlucocorticoid feedback regulationCentral stress response systemAdrenal axis regulationHypothalamic pituitary adrenal (HPA) axis regulationPlasma cortisol responseGlucocorticoid feedbackHealthy womenAdrenal axisDexamethasone suppressionLuteal phasePsychiatric illnessAxis regulationPremenstrual symptomsCortisol responsePlasma cortisolStress response systemFeedback regulationLymphocytes
1996
Naloxone-Induced Pituitary-Adrenal Activation Does Not Differ in Patients with Depression, Obsessive Compulsive Disorder, and Healthy Controls
Michelson D, Altemus M, Galliven E, Hill L, Greenberg B, Gold P. Naloxone-Induced Pituitary-Adrenal Activation Does Not Differ in Patients with Depression, Obsessive Compulsive Disorder, and Healthy Controls. Neuropsychopharmacology 1996, 15: 207-212. PMID: 8840357, DOI: 10.1016/0893-133x(95)00210-5.Peer-Reviewed Original ResearchConceptsHypothalamic CRH neuronsAdrenocorticotropic hormoneCRH neuronsCortisol secretionElevated urinary free cortisolHypothalamic CRH releaseUrinary free cortisolOpiate antagonist naloxoneEvidence of dysregulationPituitary-adrenal activationAdrenal studiesCRH releaseHormone neuronsAntagonist naloxoneHPA axisObsessive-compulsive disorderDepressed patientsHealthy controlsHypothalamic corticotropinRandomized fashionCentral stimulantsNaloxoneSeparate daysPatientsPsychiatric controls
1995
Suppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women
Altemus M, Deuster P, Galliven E, Carter C, Gold P. Suppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women. The Journal Of Clinical Endocrinology & Metabolism 1995, 80: 2954-2959. PMID: 7559880, DOI: 10.1210/jcem.80.10.7559880.Peer-Reviewed Original ResearchConceptsNeurohormonal systemsTreadmill exerciseBasal norepinephrine levelsIntensity-dependent activationAdrenal axis responseMin of exerciseMaximal oxygen uptakeSympathomedullary systemNorepinephrine levelsBreast feedingPlasma ACTHAdrenal axisNonlactating womenWeeks postpartumAxis responseGlucose responseWomenPhysical conditioningOxygen uptakeExerciseSubjectsPhysiological responsesResponseACTHPostpartum
1993
The effects of the acute administration of RU 486 on dietary fat preference in fasted lean and obese men
Kramlik S, Altemus M, Castonguay T. The effects of the acute administration of RU 486 on dietary fat preference in fasted lean and obese men. Physiology & Behavior 1993, 54: 717-724. PMID: 8248349, DOI: 10.1016/0031-9384(93)90082-q.Peer-Reviewed Original ResearchConceptsUrinary free cortisolMicrograms/24 hObese menMicrograms/dlRU 486Dietary fat preferenceLean menFat preferenceMicroIU/Double-blind crossover studyPotent glucocorticoid antagonistSelf-selected dietsHospital stayAcute administrationCrossover studyGlucocorticoid antagonistFat intakeDairy productsPlasma insulinFree cortisolLean controlsCaloric intakePlasma cortisolSecond nightDl