2004
Puberty, Ovarian Steroids, and Stress
YOUNG E, ALTEMUS M. Puberty, Ovarian Steroids, and Stress. Annals Of The New York Academy Of Sciences 2004, 1021: 124-133. PMID: 15251881, DOI: 10.1196/annals.1308.013.Peer-Reviewed Original ResearchConceptsStressful life eventsMajor depressionDepressed womenPostmenopausal depressed womenReproductive hormonal changesLife eventsNormal progesteronePremenopausal womenCommon etiologyOvarian hormonesOvarian steroidsHPA axisAdrenal axisNormal womenLow estradiolFirst episodeDepressed menHormonal changesBaseline cortisolEstradiolInhibitory feedbackPubertyYoung adulthoodWomenDepression
2001
Effects of Estrogen Antagonists and Agonists on the ACTH Response to Restraint Stress in Female Rats
Young E, Altemus M, Parkison V, Shastry S. Effects of Estrogen Antagonists and Agonists on the ACTH Response to Restraint Stress in Female Rats. Neuropsychopharmacology 2001, 25: 881-891. PMID: 11750181, DOI: 10.1016/s0893-133x(01)00301-3.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAnimalsAnti-Inflammatory AgentsCorticosteroneDrug ImplantsEstradiolEstrogen AntagonistsEstrogensFeedbackFemaleGlucocorticoidsHypothalamo-Hypophyseal SystemMaleNitromifeneOvariectomyProgesteroneRatsRats, Sprague-DawleyRestraint, PhysicalStress, PsychologicalTamoxifenConceptsRestraint stressACTH responseCorticosterone responseFemale ratsDays of estradiolLow-dose estradiolExogenous glucocorticoid administrationEstrogen antagonist tamoxifenCombination of estradiolAdrenal stress responseImportant inhibitory factorProgesterone replacementDose estradiolGlucocorticoid administrationEstrogen contributesAntagonist tamoxifenEstrogen antagonistEstradiol treatmentACTHInhibitory factorEstradiolRatsTamoxifenProgesteroneSex differences
1997
Reduced Sensitivity to Glucocorticoid Feedback and Reduced Glucocorticoid Receptor mRNA Expression in the Luteal Phase of the Menstrual Cycle
Altemus M, Redwine L, Leong Y, Yoshikawa T, Yehuda R, Detera-Wadleigh S, Murphy D. Reduced Sensitivity to Glucocorticoid Feedback and Reduced Glucocorticoid Receptor mRNA Expression in the Luteal Phase of the Menstrual Cycle. Neuropsychopharmacology 1997, 17: 100-109. PMID: 9252985, DOI: 10.1016/s0893-133x(97)00039-0.Peer-Reviewed Original ResearchConceptsMid-luteal phaseGlucocorticoid receptor mRNA expressionReceptor mRNA expressionMenstrual cycleMRNA expressionFollicular phaseCommon premenstrual symptomsGlucocorticoid feedback regulationCentral stress response systemAdrenal axis regulationHypothalamic pituitary adrenal (HPA) axis regulationPlasma cortisol responseGlucocorticoid feedbackHealthy womenAdrenal axisDexamethasone suppressionLuteal phasePsychiatric illnessAxis regulationPremenstrual symptomsCortisol responsePlasma cortisolStress response systemFeedback regulationLymphocytes
1995
Stress and antidepressants differentially regulate neurotrophin 3 mRNA expression in the locus coeruleus.
Smith M, Makino S, Altemus M, Michelson D, Hong S, Kvetnansky R, Post R. Stress and antidepressants differentially regulate neurotrophin 3 mRNA expression in the locus coeruleus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 8788-8792. PMID: 7568018, PMCID: PMC41052, DOI: 10.1073/pnas.92.19.8788.Peer-Reviewed Original ResearchConceptsNT-3 mRNA levelsLocus coeruleusNT-3MRNA levelsNeurotrophin-3 (NT-3) mRNA expressionSerotonin-specific reuptake inhibitorsNT-3 levelsNT-3 expressionSurvival of neuronsEffects of stressAntidepressant treatmentElectroconvulsive seizuresChronic treatmentLC neuronsNoradrenergic neuronsReuptake inhibitorsNeurotrophin expressionNeurotrophic factorNeurotrophin-3Norepinephrine uptakeImmobilization stressMood disordersLC functionAntidepressantsClinical depression