1999
Open trial of flutamide for treatment of obsessive-compulsive disorder.
Altemus M, Greenberg B, Keuler D, Jacobson K, Murphy D. Open trial of flutamide for treatment of obsessive-compulsive disorder. The Journal Of Clinical Psychiatry 1999, 60: 442-5. PMID: 10453797, DOI: 10.4088/jcp.v60n0704.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderAndrogen receptorEstrogen receptorClassical intracellular androgen receptorsOCD symptomsPrimary outcome measureFuture treatment trialsIntracellular androgen receptorHamilton Rating ScaleGonadal steroid hormonesAndrogen receptor antagonistYale-Brown Obsessive Compulsive ScaleEffect of treatmentBeck Anxiety InventoryLack of responseObsessive Compulsive ScaleOpen trialTreatment trialsReceptor antagonistGonadal steroidsOutcome measuresCompetitive antagonistEstrogen activityFlutamideSteroid hormones
1993
CSF somatostatin in obsessive-compulsive disorder
Altemus M, Pigott T, L'Heureux F, Davis C, Rubinow D, Murphy D, Gold P. CSF somatostatin in obsessive-compulsive disorder. American Journal Of Psychiatry 1993, 150: 460-464. PMID: 8094599, DOI: 10.1176/ajp.150.3.460.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderCSF somatostatinDrug-free outpatientsSerotonin reuptake inhibitorsSpectrum of disordersSubstantial cognitive deficitsMeasurement of somatostatinPredominant symptomReuptake inhibitorsSomatostatin activitySomatostatin levelsBrain contentPatient subgroupsClinical symptomatologyNormal subjectsNormal volunteersSomatostatinPatientsNeuropharmacological agentsExperimental animalsCognitive deficitsCentral administrationDisordersFunctional significance
1991
Symptoms of eating disorders in patients with obsessive-compulsive disorder
Pigott T, Altemus M, Rubenstein C, Hill J, Bihari K, L'Heureux F, Bernstein S, Murphy D. Symptoms of eating disorders in patients with obsessive-compulsive disorder. American Journal Of Psychiatry 1991, 148: 1552-1557. PMID: 1928472, DOI: 10.1176/ajp.148.11.1552.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderEating Disorder InventoryHealthy comparison subjectsDisorder InventoryComparison subjectsSelf-rating scaleBody dissatisfactionEating AttitudesInteroceptive awarenessDisorder displayInterpersonal distrustMaturity fearsBehavioral dimensionsBulimia nervosaAnorexia nervosaFemale normal subjectsReliable measureMore symptomsDisorders ClinicFemale inpatientsInventoryNervosaPotential overlapDisordersAttitudes