2005
Synchronized Maternal-Infant Elevations of Primate CSF CRF Concentrations in Response to Variable Foraging Demand
Coplan J, Altemus M, Mathew S, Smith E, Sharf B, Coplan P, Kral J, Gorman J, Owens M, Nemeroff C, Rosenblum L. Synchronized Maternal-Infant Elevations of Primate CSF CRF Concentrations in Response to Variable Foraging Demand. CNS Spectrums 2005, 10: 530-536. PMID: 16155510, DOI: 10.1017/s109285290001018x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAppetitive BehaviorBehavior, AnimalCorticotropin-Releasing HormoneFeeding BehaviorMacaca radiataMaternal BehaviorConceptsCentral corticotropin-releasing factorCSF CRF concentrationsCRF concentrationsCentral CRF systemCorticotropin-releasing factorSignificant mean increaseCerebrospinal fluid samplesEarly life stressorsVFD conditionsInfant sex differencesEnvironment-gene interactionsCRF levelsCRF expressionPsychiatric disordersCRF responseCRF systemInfant's lifeMean increaseDays postpartumInfantsStudy periodFluid samplesMothersMaternal responsivitySex differencesSex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression
Roca C, Schmidt P, Deuster P, Danaceau M, Altemus M, Putnam K, Chrousos G, Nieman L, Rubinow D. Sex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression. The Journal Of Clinical Endocrinology & Metabolism 2005, 90: 4224-4231. PMID: 15886244, DOI: 10.1210/jc.2004-2525.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenocorticotropic HormoneAdultCarrier ProteinsCorticotropin-Releasing HormoneExerciseHumansHydrocortisoneHypothalamo-Hypophyseal SystemMiddle AgedPituitary-Adrenal SystemSex CharacteristicsConceptsSex-related differencesGonadal suppressionReproductive steroid levelsHypogonadal conditionsAdrenal axisSteroid levelsCortisol-binding globulin levelsCRH stimulation testSex differencesHPA axis measuresHPA axis responseMain outcome measuresHPA axis activityMiddle-aged menFemale normal volunteersLeuprolide injectionACTH ratioCRH stimulationOutpatient clinicStimulation testLeuprolide acetateTime of testingAdrenal responsivityAxis activityGlobulin levels
2002
Differing concentrations of corticotropin-releasing factor and oxytocin in the cerebrospinal fluid of bonnet and pigtail macaques
Rosenblum L, Smith E, Altemus M, Scharf B, Owens M, Nemeroff C, Gorman J, Coplan J. Differing concentrations of corticotropin-releasing factor and oxytocin in the cerebrospinal fluid of bonnet and pigtail macaques. Psychoneuroendocrinology 2002, 27: 651-660. PMID: 12084658, DOI: 10.1016/s0306-4530(01)00056-7.Peer-Reviewed Original ResearchAnimalsCorticotropin-Releasing HormoneFemaleMacaca nemestrinaMacaca radiataMaleOxytocinReference ValuesRegression AnalysisSpecies Specificity
2001
Variable foraging demand rearing: sustained elevations in cisternal cerebrospinal fluid corticotropin-releasing factor concentrations in adult primates
Coplan J, Smith E, Altemus M, Scharf B, Owens M, Nemeroff C, Gorman J, Rosenblum L. Variable foraging demand rearing: sustained elevations in cisternal cerebrospinal fluid corticotropin-releasing factor concentrations in adult primates. Biological Psychiatry 2001, 50: 200-204. PMID: 11513819, DOI: 10.1016/s0006-3223(01)01175-1.Peer-Reviewed Original ResearchConceptsCerebrospinal fluid corticotropin-releasing factor concentrationsCorticotropin-releasing factor concentrationsFactor concentrationsCSF CRFAdult primatesYoung adult primatesYoung adulthoodCisternal CSF samplesCSF samplesCRF functionControl groupCRF valuesSignificant positive correlationAd libitumPresent studyJuvenile primatesPositive correlationAdulthoodPrimatesCRFElevationAbnormalities in response to vasopressin infusion in chronic fatigue syndrome
Altemus M, Dale J, Michelson D, Demitrack M, Gold P, Straus S. Abnormalities in response to vasopressin infusion in chronic fatigue syndrome. Psychoneuroendocrinology 2001, 26: 175-188. PMID: 11087963, DOI: 10.1016/s0306-4530(00)00044-5.Peer-Reviewed Original ResearchConceptsChronic fatigue syndromeCorticotropin-releasing hormoneHypothalamic CRH secretionFatigue syndromeCRH secretionACTH responseVasopressin infusionCortisol responsePeripheral infusionHour infusionACTH secretionNeuroendocrine abnormalitiesAdrenal axisHypothalamic secretionHypothalamus actsHealthy volunteersPrimary symptomsNeuroendocrine studiesArginine vasopressinInfusionSyndromePatientsSecretionVasopressinAbnormalities
2000
Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations
Coplan J, Smith E, Trost R, Scharf B, Altemus M, Bjornson L, Owens M, Gorman J, Nemeroff C, Rosenblum L. Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations. Psychiatry Research 2000, 95: 93-102. PMID: 10963795, DOI: 10.1016/s0165-1781(00)00173-6.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-AgonistsAnimalsBehavior, AnimalClonidineCorticotropin-Releasing HormoneFemaleGrowth HormoneMacaca radiataMaleConceptsCSF CRF concentrationsVariable foraging demandGrowth hormone responseGH responseCRF concentrationsCerebrospinal fluid corticotropin-releasing factor concentrationsHormone responseCorticotropin-releasing factor concentrationsAdult primatesDosage of clonidineYoung adult primatesAdrenergic agonist clonidineCorticotropin-releasing factorAgonist clonidineNeuroendocrine abnormalitiesPersistent elevationPrevious primate studiesGH releaseGH-like immunoreactivitySignificant inverse relationshipKetamine anesthesiaClonidineCRF activityHuman patientsFactor concentrations
1994
Changes in Cerebrospinal Fluid Neurochemistry During Treatment of Obsessive-compulsive Disorder With Clomipramine
Altemus M, Swedo S, Leonard H, Richter D, Rubinow D, Potter W, Rapoport J. Changes in Cerebrospinal Fluid Neurochemistry During Treatment of Obsessive-compulsive Disorder With Clomipramine. JAMA Psychiatry 1994, 51: 794-803. PMID: 7524463, DOI: 10.1001/archpsyc.1994.03950100042004.Peer-Reviewed Original ResearchConceptsCorticotropin-releasing hormoneLong-term treatmentObsessive-compulsive disorderCSF levelsHomovanillic acidCSF monoamine metabolite levelsCentral administrationCerebrospinal fluid levelsSignificant decreaseCSF homovanillic acidMonoamine metabolite levelsCerebrospinal fluid neurochemistryCSF oxytocin levelsOpposite behavioral effectsPharmacologic treatmentSomatostatin levelsMonoamine metabolitesPathophysiologic processesFluid levelsBehavioral effectsOxytocin levelsClomipramine hydrochlorideMetabolite levelsDisordersVasopressinIncreased mRNA for corticotrophin releasing hormone in the amygdala of Fawn‐hooded rats: A potential animal model of anxiety
Altemus M, Smith M, Diep V, Aulakh C, Murphy D. Increased mRNA for corticotrophin releasing hormone in the amygdala of Fawn‐hooded rats: A potential animal model of anxiety. Anxiety 1994, 1: 251-257. PMID: 9160583, DOI: 10.1002/anxi.3070010602.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaAnimalsAnxiety DisordersArousalCorticosteroneCorticotropin-Releasing HormoneDisease Models, AnimalHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemRatsRats, Inbred StrainsRats, WistarReceptors, GlucocorticoidReceptors, MineralocorticoidRNA, MessengerSpecies SpecificityTyrosine 3-MonooxygenaseConceptsFawn-Hooded ratsAdrenal axis activityBasal corticosterone levelsParaventricular nucleusCRH mRNAAdrenal weightAxis activityWistar ratsReceptor mRNACorticosterone levelsArginine vasopressinRat strainsCentral nucleusAdult-onset hypertensionFawn-hooded strainFawn-hooded rat strainMineralocorticoid receptor mRNAUrinary catecholamine levelsHypothalamic paraventricular nucleusGlucocorticoid receptor mRNAWistar rat strainPotential animal modelTyrosine hydroxylase mRNAMore freezing behaviorAVP mRNA expression
1992
Abnormalities in the Regulation of Vasopressin and Corticotropin Releasing Factor Secretion in Obsessive-Compulsive Disorder
Altemus M, Pigott T, Kalogeras K, Demitrack M, Dubbert B, Murphy D, Gold P. Abnormalities in the Regulation of Vasopressin and Corticotropin Releasing Factor Secretion in Obsessive-Compulsive Disorder. JAMA Psychiatry 1992, 49: 9-20. PMID: 1370198, DOI: 10.1001/archpsyc.1992.01820010009002.Peer-Reviewed Original Research