2006
Romantic Love and Sexual Desire in Close Relationships
Gonzaga G, Turner R, Keltner D, Campos B, Altemus M. Romantic Love and Sexual Desire in Close Relationships. Emotion 2006, 6: 163-179. PMID: 16768550, DOI: 10.1037/1528-3542.6.2.163.Peer-Reviewed Original Research
2005
Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle
Protopopescu X, Pan H, Altemus M, Tuescher O, Polanecsky M, McEwen B, Silbersweig D, Stern E. Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 16060-16065. PMID: 16247013, PMCID: PMC1276043, DOI: 10.1073/pnas.0502818102.Peer-Reviewed Original ResearchSex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression
Roca C, Schmidt P, Deuster P, Danaceau M, Altemus M, Putnam K, Chrousos G, Nieman L, Rubinow D. Sex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression. The Journal Of Clinical Endocrinology & Metabolism 2005, 90: 4224-4231. PMID: 15886244, DOI: 10.1210/jc.2004-2525.Peer-Reviewed Original ResearchConceptsSex-related differencesGonadal suppressionReproductive steroid levelsHypogonadal conditionsAdrenal axisSteroid levelsCortisol-binding globulin levelsCRH stimulation testSex differencesHPA axis measuresHPA axis responseMain outcome measuresHPA axis activityMiddle-aged menFemale normal volunteersLeuprolide injectionACTH ratioCRH stimulationOutpatient clinicStimulation testLeuprolide acetateTime of testingAdrenal responsivityAxis activityGlobulin levels
2004
HPA axis activation in major depression and response to fluoxetine: a pilot study
Young E, Altemus M, Lopez J, Kocsis J, Schatzberg A, deBattista C, Zubieta J. HPA axis activation in major depression and response to fluoxetine: a pilot study. Psychoneuroendocrinology 2004, 29: 1198-1204. PMID: 15219644, DOI: 10.1016/j.psyneuen.2004.02.002.Peer-Reviewed Original ResearchConceptsHPA axis activationMetyrapone challengeOnset of treatmentAxis activationMajor depressionHPA axisHamilton Depression Rating Scale ratingsOpen-label treatmentHPA axis dysregulationAdrenal axis activationPremenopausal womenLabel treatmentACTH levelsHormonal contraceptivesMedical illnessACTH secretionAxis dysregulationNormal womenDepressed patientsFluoxetine respondersDepressed womenNormal subjectsAxis IGreater severityFluoxetine
2003
Enhanced Cellular Immune Response in Women With PTSD Related to Childhood Abuse
Altemus M, Cloitre M, Dhabhar F. Enhanced Cellular Immune Response in Women With PTSD Related to Childhood Abuse. American Journal Of Psychiatry 2003, 160: 1705-1707. PMID: 12944352, DOI: 10.1176/appi.ajp.160.9.1705.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderDelayed-type hypersensitivity (DTH) skin test responsesCircadian salivary cortisol levelsHypersensitivity skin test responsesDelayed-type hypersensitivitySkin test responsesCellular immune responsesHPA axis activityCell-mediated inflammatory reactionsHealthy comparison subjectsSalivary cortisol levelsAdrenal axisSympathoadrenomedullary systemAxis activityInflammatory reactionImmune responseImmune functionPsychiatric disordersComparison subjectsCortisol levelsPlasma cortisolHistory of abuseSingle time point measurementStress disorderTime point measurementsDifferential Menstrual Cycle Regulation of Hypothalamic-Pituitary-Adrenal Axis in Women with Premenstrual Syndrome and Controls
Roca C, Schmidt P, Altemus M, Deuster P, Danaceau M, Putnam K, Rubinow D. Differential Menstrual Cycle Regulation of Hypothalamic-Pituitary-Adrenal Axis in Women with Premenstrual Syndrome and Controls. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 3057-3063. PMID: 12843143, DOI: 10.1210/jc.2002-021570.Peer-Reviewed Original ResearchConceptsHPA axis responsePremenstrual syndromeAdrenal axisControl womenMajor depressionLuteal phaseReproductive steroidsAxis responseTreadmill exercise stress testingHPA axis modulationMenstrual cycle regulationHPA axis abnormalitiesExercise stress testingHPA axis regulationStress testingMenstrual cycle phaseAxis abnormalitiesHPA axisMenstrual cycleGonadal steroidsAbnormal responseAxis regulationAffective disordersAffective symptomsPotent modulator
2002
Effects of Emotion on Oxytocin, Prolactin, and ACTH in Women
Turner R, Altemus M, Yip D, Kupferman E, Fletcher D, Bostrom A, Lyons D, Amico J. Effects of Emotion on Oxytocin, Prolactin, and ACTH in Women. Stress 2002, 5: 269-276. PMID: 12475731, DOI: 10.1080/1025389021000037586-1.Peer-Reviewed Original ResearchConceptsNegative emotion inductionEmotion inductionNegative emotionsAttachment-related emotionsPositive emotion inductionEffects of emotionPositive emotionsSad emotionsHuman attachmentNon-human mammalsPlasma oxytocin levelsEmotionsInterpersonal relationshipsOxytocin levelsPlasma oxytocinPrevious researchOxytocinDegree of changeResearchParticipantsFemale volunteersUniversity communityAttachmentFindingsRelationship
2001
Responses to Laboratory Psychosocial Stress in Postpartum Women
Altemus M, Redwine L, Leong Y, Frye C, Porges S, Carter C. Responses to Laboratory Psychosocial Stress in Postpartum Women. Psychosomatic Medicine 2001, 63: 814-821. PMID: 11573030, DOI: 10.1097/00006842-200109000-00015.Peer-Reviewed Original ResearchConceptsSystolic blood pressureBlood pressurePostpartum womenCardiac vagal toneHeart rateNonlactating womenVagal controlVagal toneParasympathetic nervous system toneHigher systolic blood pressurePsychological stressDiastolic blood pressureEarly follicular phaseHealthy control womenAutonomic nervous systemTrier Social Stress TestAllopregnanolone levelsControl womenAdrenal axisLower cardiac vagal toneFollicular phaseControl subjectsMenstrual cycleSocial Stress TestEffect of lactationStress-Induced Changes in Skin Barrier Function in Healthy Women
Altemus M, Rao B, Dhabhar F, Ding W, Granstein R. Stress-Induced Changes in Skin Barrier Function in Healthy Women. Journal Of Investigative Dermatology 2001, 117: 309-317. PMID: 11511309, DOI: 10.1046/j.1523-1747.2001.01373.x.Peer-Reviewed Original ResearchConceptsNatural killer cell activityKiller cell activityBarrier function recoverySkin barrier functionSkin barrier function recoveryFunction recoveryCell activityInterview stressSleep deprivationTumor necrosisBarrier functionInterleukin-1betaNatural killer cell numbersStress-induced changesPlasma interleukin-1betaHelper T cellsPeripheral blood leukocytesCytolytic T lymphocytesTransepidermal water lossClear exacerbationCytokine responsesHealthy womenInterleukin-10Exercise protocolPlasma levelsIncreased Vasopressin and Adrenocorticotropin Responses to Stress in the Midluteal Phase of the Menstrual Cycle
Altemus M, Roca C, Galliven E, Romanos C, Deuster P. Increased Vasopressin and Adrenocorticotropin Responses to Stress in the Midluteal Phase of the Menstrual Cycle. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 2525-2530. PMID: 11397850, DOI: 10.1210/jcem.86.6.7596.Peer-Reviewed Original ResearchConceptsEarly follicular phaseMaximal oxygen consumptionMidluteal phaseMenstrual cycleFollicular phaseGonadal steroidsNatural menstrual cycleMin of exerciseHPA axis responsivityGonadal steroid levelsPathophysiology of anxietyAdrenocorticotropin responseHealthy womenEstrogen levelsHPA axisAdrenal axisExercise stressSteroid levelsCortisol levelsExercise intensityPlasma lactateHormonal responsesVasopressinProvide protectionACTHLymphocyte responses to stress in postpartum women: relationship to vagal tone
Redwine L, Altemus M, Leong Y, Carter C. Lymphocyte responses to stress in postpartum women: relationship to vagal tone. Psychoneuroendocrinology 2001, 26: 241-251. PMID: 11166487, DOI: 10.1016/s0306-4530(00)00049-4.Peer-Reviewed Original ResearchConceptsPoke-weed mitogenLymphocyte responsesLymphocyte proliferationVagal toneImmune responseNon-postpartum womenCellular immune responsesLymphocyte proliferation responseCardiac vagal toneBlood pressureHPA axisPostpartum womenFollicular phaseParturient womenVagal systemHeart rateProliferation responseEndocrine measuresWeed mitogenStress-induced changesPhytohemagglutininWomenAutonomic measuresBottlefeedingRegression analysisAbnormalities in response to vasopressin infusion in chronic fatigue syndrome
Altemus M, Dale J, Michelson D, Demitrack M, Gold P, Straus S. Abnormalities in response to vasopressin infusion in chronic fatigue syndrome. Psychoneuroendocrinology 2001, 26: 175-188. PMID: 11087963, DOI: 10.1016/s0306-4530(00)00044-5.Peer-Reviewed Original ResearchConceptsChronic fatigue syndromeCorticotropin-releasing hormoneHypothalamic CRH secretionFatigue syndromeCRH secretionACTH responseVasopressin infusionCortisol responsePeripheral infusionHour infusionACTH secretionNeuroendocrine abnormalitiesAdrenal axisHypothalamic secretionHypothalamus actsHealthy volunteersPrimary symptomsNeuroendocrine studiesArginine vasopressinInfusionSyndromePatientsSecretionVasopressinAbnormalities
2000
CSF oxytocin and vasopressin levels after recovery from bulimia nervosa and anorexia nervosa, bulimic subtype
Frank G, Kaye W, Altemus M, Greeno C. CSF oxytocin and vasopressin levels after recovery from bulimia nervosa and anorexia nervosa, bulimic subtype. Biological Psychiatry 2000, 48: 315-318. PMID: 10960163, DOI: 10.1016/s0006-3223(00)00243-2.Peer-Reviewed Original ResearchConceptsCerebrospinal fluid vasopressinMajor depressionBulimia nervosaAnorexia nervosaLifetime historyBirth control pill useHealthy control womenBulimic subtypeControl womenVasopressin levelsPill useRecovered subjectsIll stateElevated levelsVasopressinNervosaCSF oxytocinOxytocinNeuropeptide vasopressinCerebrospinal fluid oxytocinWomenDisordersDepression
1999
Open trial of flutamide for treatment of obsessive-compulsive disorder.
Altemus M, Greenberg B, Keuler D, Jacobson K, Murphy D. Open trial of flutamide for treatment of obsessive-compulsive disorder. The Journal Of Clinical Psychiatry 1999, 60: 442-5. PMID: 10453797, DOI: 10.4088/jcp.v60n0704.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderAndrogen receptorEstrogen receptorClassical intracellular androgen receptorsOCD symptomsPrimary outcome measureFuture treatment trialsIntracellular androgen receptorHamilton Rating ScaleGonadal steroid hormonesAndrogen receptor antagonistYale-Brown Obsessive Compulsive ScaleEffect of treatmentBeck Anxiety InventoryLack of responseObsessive Compulsive ScaleOpen trialTreatment trialsReceptor antagonistGonadal steroidsOutcome measuresCompetitive antagonistEstrogen activityFlutamideSteroid hormonesLeptin, neuropeptide Y, and peptide YY in long-term recovered eating disorder patients
Gendall K, Kaye W, Altemus M, McConaha C, La Via M. Leptin, neuropeptide Y, and peptide YY in long-term recovered eating disorder patients. Biological Psychiatry 1999, 46: 292-299. PMID: 10418705, DOI: 10.1016/s0006-3223(98)00292-3.Peer-Reviewed Original ResearchPreliminary Research on Plasma Oxytocin in Normal Cycling Women: Investigating Emotion and Interpersonal Distress
Turner R, Altemus M, Enos T, Cooper B, McGuinness T. Preliminary Research on Plasma Oxytocin in Normal Cycling Women: Investigating Emotion and Interpersonal Distress. Psychiatry 1999, 62: 97-113. PMID: 10420425, DOI: 10.1080/00332747.1999.11024859.Peer-Reviewed Original ResearchConceptsOxytocin levelsPositive emotionsImagery tasksInterpersonal problemsInterpersonal distressInterpersonal characteristicsPositive social contactAdult pair bondsPlasma oxytocinEmotional stimuliSad emotionsSocial stimuliNegative emotionsIndividual differencesLower anxietyEmotionsCouple relationshipsNeurohormone oxytocinNonhuman mammalsSocial contactMaternal behaviorDistressStimuliOxytocinTaskNormal CSF oxytocin and NPY levels in OCD
Altemus M, Jacobson K, Debellis M, Kling M, Pigott T, Murphy D, Gold P. Normal CSF oxytocin and NPY levels in OCD. Biological Psychiatry 1999, 45: 931-933. PMID: 10202583, DOI: 10.1016/s0006-3223(98)00263-7.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderNPY levelsCSF levelsOCD patientsCSF oxytocinCentral nervous system neuropeptidesIncreased CSF levelsHealthy normal volunteersControl subjectsNPY regulationNormal volunteersHigher CSFSymptom profilesControl groupPatientsPotential mediatorsNeuropeptidesOxytocinSignificant differencesNPYCSFLevelsPrior findingsAbnormalities
1998
Delayed obsessive-compulsive disorder symptom exacerbation after a single dose of a serotonin antagonist in fluoxetine-treated but not untreated patients
Greenberg B, Benjamin J, Martin J, Keuler D, Huang S, Altemus M, Murphy D. Delayed obsessive-compulsive disorder symptom exacerbation after a single dose of a serotonin antagonist in fluoxetine-treated but not untreated patients. Psychopharmacology 1998, 140: 434-444. PMID: 9888619, DOI: 10.1007/s002130050787.Peer-Reviewed Original ResearchConceptsFluoxetine-treated patientsObsessive-compulsive disorderUnmedicated patientsAdministration of metergolineSerotonin reuptake inhibitorsUnderlie symptomsUntreated patientsBrain serotoninReuptake inhibitorsSerotonin antagonistsSerotonergic transmissionSingle doseSymptom exacerbationReceptor responsivityTherapeutic effectMetergolinePatientsPlaceboSymptom ratingsSymptomsSuch treatmentSerotoninDisordersPilot resultsDays
1997
Reduced Sensitivity to Glucocorticoid Feedback and Reduced Glucocorticoid Receptor mRNA Expression in the Luteal Phase of the Menstrual Cycle
Altemus M, Redwine L, Leong Y, Yoshikawa T, Yehuda R, Detera-Wadleigh S, Murphy D. Reduced Sensitivity to Glucocorticoid Feedback and Reduced Glucocorticoid Receptor mRNA Expression in the Luteal Phase of the Menstrual Cycle. Neuropsychopharmacology 1997, 17: 100-109. PMID: 9252985, DOI: 10.1016/s0893-133x(97)00039-0.Peer-Reviewed Original ResearchConceptsMid-luteal phaseGlucocorticoid receptor mRNA expressionReceptor mRNA expressionMenstrual cycleMRNA expressionFollicular phaseCommon premenstrual symptomsGlucocorticoid feedback regulationCentral stress response systemAdrenal axis regulationHypothalamic pituitary adrenal (HPA) axis regulationPlasma cortisol responseGlucocorticoid feedbackHealthy womenAdrenal axisDexamethasone suppressionLuteal phasePsychiatric illnessAxis regulationPremenstrual symptomsCortisol responsePlasma cortisolStress response systemFeedback regulationLymphocytesEffect of prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: a preliminary study
Greenberg B, George M, Martin J, Benjamin J, Schlaepfer T, Altemus M, Wassermann E, Post R, Murphy D. Effect of prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: a preliminary study. American Journal Of Psychiatry 1997, 154: 867-869. PMID: 9167520, DOI: 10.1176/ajp.154.6.867.Peer-Reviewed Original Research