2005
Sex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression
Roca C, Schmidt P, Deuster P, Danaceau M, Altemus M, Putnam K, Chrousos G, Nieman L, Rubinow D. Sex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression. The Journal Of Clinical Endocrinology & Metabolism 2005, 90: 4224-4231. PMID: 15886244, DOI: 10.1210/jc.2004-2525.Peer-Reviewed Original ResearchConceptsSex-related differencesGonadal suppressionReproductive steroid levelsHypogonadal conditionsAdrenal axisSteroid levelsCortisol-binding globulin levelsCRH stimulation testSex differencesHPA axis measuresHPA axis responseMain outcome measuresHPA axis activityMiddle-aged menFemale normal volunteersLeuprolide injectionACTH ratioCRH stimulationOutpatient clinicStimulation testLeuprolide acetateTime of testingAdrenal responsivityAxis activityGlobulin levels
2004
HPA axis activation in major depression and response to fluoxetine: a pilot study
Young E, Altemus M, Lopez J, Kocsis J, Schatzberg A, deBattista C, Zubieta J. HPA axis activation in major depression and response to fluoxetine: a pilot study. Psychoneuroendocrinology 2004, 29: 1198-1204. PMID: 15219644, DOI: 10.1016/j.psyneuen.2004.02.002.Peer-Reviewed Original ResearchConceptsHPA axis activationMetyrapone challengeOnset of treatmentAxis activationMajor depressionHPA axisHamilton Depression Rating Scale ratingsOpen-label treatmentHPA axis dysregulationAdrenal axis activationPremenopausal womenLabel treatmentACTH levelsHormonal contraceptivesMedical illnessACTH secretionAxis dysregulationNormal womenDepressed patientsFluoxetine respondersDepressed womenNormal subjectsAxis IGreater severityFluoxetine
2003
Differential Menstrual Cycle Regulation of Hypothalamic-Pituitary-Adrenal Axis in Women with Premenstrual Syndrome and Controls
Roca C, Schmidt P, Altemus M, Deuster P, Danaceau M, Putnam K, Rubinow D. Differential Menstrual Cycle Regulation of Hypothalamic-Pituitary-Adrenal Axis in Women with Premenstrual Syndrome and Controls. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 3057-3063. PMID: 12843143, DOI: 10.1210/jc.2002-021570.Peer-Reviewed Original ResearchConceptsHPA axis responsePremenstrual syndromeAdrenal axisControl womenMajor depressionLuteal phaseReproductive steroidsAxis responseTreadmill exercise stress testingHPA axis modulationMenstrual cycle regulationHPA axis abnormalitiesExercise stress testingHPA axis regulationStress testingMenstrual cycle phaseAxis abnormalitiesHPA axisMenstrual cycleGonadal steroidsAbnormal responseAxis regulationAffective disordersAffective symptomsPotent modulator
2002
Effects of Emotion on Oxytocin, Prolactin, and ACTH in Women
Turner R, Altemus M, Yip D, Kupferman E, Fletcher D, Bostrom A, Lyons D, Amico J. Effects of Emotion on Oxytocin, Prolactin, and ACTH in Women. Stress 2002, 5: 269-276. PMID: 12475731, DOI: 10.1080/1025389021000037586-1.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAdultAnalysis of VarianceEmotionsFemaleHumansIndividualityMotion PicturesOsmolar ConcentrationOxytocinProlactinConceptsNegative emotion inductionEmotion inductionNegative emotionsAttachment-related emotionsPositive emotion inductionEffects of emotionPositive emotionsSad emotionsHuman attachmentNon-human mammalsPlasma oxytocin levelsEmotionsInterpersonal relationshipsOxytocin levelsPlasma oxytocinPrevious researchOxytocinDegree of changeResearchParticipantsFemale volunteersUniversity communityAttachmentFindingsRelationship
2001
Stress-Induced Changes in Skin Barrier Function in Healthy Women
Altemus M, Rao B, Dhabhar F, Ding W, Granstein R. Stress-Induced Changes in Skin Barrier Function in Healthy Women. Journal Of Investigative Dermatology 2001, 117: 309-317. PMID: 11511309, DOI: 10.1046/j.1523-1747.2001.01373.x.Peer-Reviewed Original ResearchConceptsNatural killer cell activityKiller cell activityBarrier function recoverySkin barrier functionSkin barrier function recoveryFunction recoveryCell activityInterview stressSleep deprivationTumor necrosisBarrier functionInterleukin-1betaNatural killer cell numbersStress-induced changesPlasma interleukin-1betaHelper T cellsPeripheral blood leukocytesCytolytic T lymphocytesTransepidermal water lossClear exacerbationCytokine responsesHealthy womenInterleukin-10Exercise protocolPlasma levelsEffects of Estrogen Antagonists and Agonists on the ACTH Response to Restraint Stress in Female Rats
Young E, Altemus M, Parkison V, Shastry S. Effects of Estrogen Antagonists and Agonists on the ACTH Response to Restraint Stress in Female Rats. Neuropsychopharmacology 2001, 25: 881-891. PMID: 11750181, DOI: 10.1016/s0893-133x(01)00301-3.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAnimalsAnti-Inflammatory AgentsCorticosteroneDrug ImplantsEstradiolEstrogen AntagonistsEstrogensFeedbackFemaleGlucocorticoidsHypothalamo-Hypophyseal SystemMaleNitromifeneOvariectomyProgesteroneRatsRats, Sprague-DawleyRestraint, PhysicalStress, PsychologicalTamoxifenConceptsRestraint stressACTH responseCorticosterone responseFemale ratsDays of estradiolLow-dose estradiolExogenous glucocorticoid administrationEstrogen antagonist tamoxifenCombination of estradiolAdrenal stress responseImportant inhibitory factorProgesterone replacementDose estradiolGlucocorticoid administrationEstrogen contributesAntagonist tamoxifenEstrogen antagonistEstradiol treatmentACTHInhibitory factorEstradiolRatsTamoxifenProgesteroneSex differencesIncreased Vasopressin and Adrenocorticotropin Responses to Stress in the Midluteal Phase of the Menstrual Cycle
Altemus M, Roca C, Galliven E, Romanos C, Deuster P. Increased Vasopressin and Adrenocorticotropin Responses to Stress in the Midluteal Phase of the Menstrual Cycle. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 2525-2530. PMID: 11397850, DOI: 10.1210/jcem.86.6.7596.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAdultBlood GlucoseExerciseFemaleHumansLuteal PhaseStress, PhysiologicalVasopressinsConceptsEarly follicular phaseMaximal oxygen consumptionMidluteal phaseMenstrual cycleFollicular phaseGonadal steroidsNatural menstrual cycleMin of exerciseHPA axis responsivityGonadal steroid levelsPathophysiology of anxietyAdrenocorticotropin responseHealthy womenEstrogen levelsHPA axisAdrenal axisExercise stressSteroid levelsCortisol levelsExercise intensityPlasma lactateHormonal responsesVasopressinProvide protectionACTHAbnormalities in response to vasopressin infusion in chronic fatigue syndrome
Altemus M, Dale J, Michelson D, Demitrack M, Gold P, Straus S. Abnormalities in response to vasopressin infusion in chronic fatigue syndrome. Psychoneuroendocrinology 2001, 26: 175-188. PMID: 11087963, DOI: 10.1016/s0306-4530(00)00044-5.Peer-Reviewed Original ResearchConceptsChronic fatigue syndromeCorticotropin-releasing hormoneHypothalamic CRH secretionFatigue syndromeCRH secretionACTH responseVasopressin infusionCortisol responsePeripheral infusionHour infusionACTH secretionNeuroendocrine abnormalitiesAdrenal axisHypothalamic secretionHypothalamus actsHealthy volunteersPrimary symptomsNeuroendocrine studiesArginine vasopressinInfusionSyndromePatientsSecretionVasopressinAbnormalities
1996
Naloxone-Induced Pituitary-Adrenal Activation Does Not Differ in Patients with Depression, Obsessive Compulsive Disorder, and Healthy Controls
Michelson D, Altemus M, Galliven E, Hill L, Greenberg B, Gold P. Naloxone-Induced Pituitary-Adrenal Activation Does Not Differ in Patients with Depression, Obsessive Compulsive Disorder, and Healthy Controls. Neuropsychopharmacology 1996, 15: 207-212. PMID: 8840357, DOI: 10.1016/0893-133x(95)00210-5.Peer-Reviewed Original ResearchConceptsHypothalamic CRH neuronsAdrenocorticotropic hormoneCRH neuronsCortisol secretionElevated urinary free cortisolHypothalamic CRH releaseUrinary free cortisolOpiate antagonist naloxoneEvidence of dysregulationPituitary-adrenal activationAdrenal studiesCRH releaseHormone neuronsAntagonist naloxoneHPA axisObsessive-compulsive disorderDepressed patientsHealthy controlsHypothalamic corticotropinRandomized fashionCentral stimulantsNaloxoneSeparate daysPatientsPsychiatric controls
1995
Suppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women
Altemus M, Deuster P, Galliven E, Carter C, Gold P. Suppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women. The Journal Of Clinical Endocrinology & Metabolism 1995, 80: 2954-2959. PMID: 7559880, DOI: 10.1210/jcem.80.10.7559880.Peer-Reviewed Original ResearchConceptsNeurohormonal systemsTreadmill exerciseBasal norepinephrine levelsIntensity-dependent activationAdrenal axis responseMin of exerciseMaximal oxygen uptakeSympathomedullary systemNorepinephrine levelsBreast feedingPlasma ACTHAdrenal axisNonlactating womenWeeks postpartumAxis responseGlucose responseWomenPhysical conditioningOxygen uptakeExerciseSubjectsPhysiological responsesResponseACTHPostpartum
1993
The effects of the acute administration of RU 486 on dietary fat preference in fasted lean and obese men
Kramlik S, Altemus M, Castonguay T. The effects of the acute administration of RU 486 on dietary fat preference in fasted lean and obese men. Physiology & Behavior 1993, 54: 717-724. PMID: 8248349, DOI: 10.1016/0031-9384(93)90082-q.Peer-Reviewed Original ResearchConceptsUrinary free cortisolMicrograms/24 hObese menMicrograms/dlRU 486Dietary fat preferenceLean menFat preferenceMicroIU/Double-blind crossover studyPotent glucocorticoid antagonistSelf-selected dietsHospital stayAcute administrationCrossover studyGlucocorticoid antagonistFat intakeDairy productsPlasma insulinFree cortisolLean controlsCaloric intakePlasma cortisolSecond nightDl