2004
HPA axis activation in major depression and response to fluoxetine: a pilot study
Young E, Altemus M, Lopez J, Kocsis J, Schatzberg A, deBattista C, Zubieta J. HPA axis activation in major depression and response to fluoxetine: a pilot study. Psychoneuroendocrinology 2004, 29: 1198-1204. PMID: 15219644, DOI: 10.1016/j.psyneuen.2004.02.002.Peer-Reviewed Original ResearchConceptsHPA axis activationMetyrapone challengeOnset of treatmentAxis activationMajor depressionHPA axisHamilton Depression Rating Scale ratingsOpen-label treatmentHPA axis dysregulationAdrenal axis activationPremenopausal womenLabel treatmentACTH levelsHormonal contraceptivesMedical illnessACTH secretionAxis dysregulationNormal womenDepressed patientsFluoxetine respondersDepressed womenNormal subjectsAxis IGreater severityFluoxetine
2003
Enhanced Cellular Immune Response in Women With PTSD Related to Childhood Abuse
Altemus M, Cloitre M, Dhabhar F. Enhanced Cellular Immune Response in Women With PTSD Related to Childhood Abuse. American Journal Of Psychiatry 2003, 160: 1705-1707. PMID: 12944352, DOI: 10.1176/appi.ajp.160.9.1705.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderDelayed-type hypersensitivity (DTH) skin test responsesCircadian salivary cortisol levelsHypersensitivity skin test responsesDelayed-type hypersensitivitySkin test responsesCellular immune responsesHPA axis activityCell-mediated inflammatory reactionsHealthy comparison subjectsSalivary cortisol levelsAdrenal axisSympathoadrenomedullary systemAxis activityInflammatory reactionImmune responseImmune functionPsychiatric disordersComparison subjectsCortisol levelsPlasma cortisolHistory of abuseSingle time point measurementStress disorderTime point measurements
1994
Pulsatility of 24-Hour Concentrations of Circulating lnterleukin-1-Alpha in Healthy Women: Analysis of Integrated Basal Levels, Discrete Pulse Properties, and Correlation with Simultaneous lnterleukin-2 Concentrations
Licinio J, Wong M, Altemus M, Bongiorno P, Bernat A, Brabant G, Tamarkin L, Gold P. Pulsatility of 24-Hour Concentrations of Circulating lnterleukin-1-Alpha in Healthy Women: Analysis of Integrated Basal Levels, Discrete Pulse Properties, and Correlation with Simultaneous lnterleukin-2 Concentrations. NeuroImmunoModulation 1994, 1: 242-250. PMID: 7489339, DOI: 10.1159/000097172.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCircadian RhythmCluster AnalysisFemaleGenetic VariationHumansInterleukin-1Interleukin-2Reference ValuesSecretory RateConceptsIL-1 alpha concentrationsIL-1 alphaAlpha concentrationsMicrograms/IL-2IL-1 alpha levelsIL-2 levelsFollicle-stimulating hormoneHealthy female volunteersCytokine cascadeHealthy womenAlpha actsSystemic circulationFemale volunteersGrowth hormoneBasal levelsAlpha levelsHormoneDistant sitesInterpulse intervalsPulsatilityAlphaSubjectsLevelsInterleukin