2005
Sex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression
Roca C, Schmidt P, Deuster P, Danaceau M, Altemus M, Putnam K, Chrousos G, Nieman L, Rubinow D. Sex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression. The Journal Of Clinical Endocrinology & Metabolism 2005, 90: 4224-4231. PMID: 15886244, DOI: 10.1210/jc.2004-2525.Peer-Reviewed Original ResearchConceptsSex-related differencesGonadal suppressionReproductive steroid levelsHypogonadal conditionsAdrenal axisSteroid levelsCortisol-binding globulin levelsCRH stimulation testSex differencesHPA axis measuresHPA axis responseMain outcome measuresHPA axis activityMiddle-aged menFemale normal volunteersLeuprolide injectionACTH ratioCRH stimulationOutpatient clinicStimulation testLeuprolide acetateTime of testingAdrenal responsivityAxis activityGlobulin levels
2004
HPA axis activation in major depression and response to fluoxetine: a pilot study
Young E, Altemus M, Lopez J, Kocsis J, Schatzberg A, deBattista C, Zubieta J. HPA axis activation in major depression and response to fluoxetine: a pilot study. Psychoneuroendocrinology 2004, 29: 1198-1204. PMID: 15219644, DOI: 10.1016/j.psyneuen.2004.02.002.Peer-Reviewed Original ResearchConceptsHPA axis activationMetyrapone challengeOnset of treatmentAxis activationMajor depressionHPA axisHamilton Depression Rating Scale ratingsOpen-label treatmentHPA axis dysregulationAdrenal axis activationPremenopausal womenLabel treatmentACTH levelsHormonal contraceptivesMedical illnessACTH secretionAxis dysregulationNormal womenDepressed patientsFluoxetine respondersDepressed womenNormal subjectsAxis IGreater severityFluoxetine
2001
Stress-Induced Changes in Skin Barrier Function in Healthy Women
Altemus M, Rao B, Dhabhar F, Ding W, Granstein R. Stress-Induced Changes in Skin Barrier Function in Healthy Women. Journal Of Investigative Dermatology 2001, 117: 309-317. PMID: 11511309, DOI: 10.1046/j.1523-1747.2001.01373.x.Peer-Reviewed Original ResearchConceptsNatural killer cell activityKiller cell activityBarrier function recoverySkin barrier functionSkin barrier function recoveryFunction recoveryCell activityInterview stressSleep deprivationTumor necrosisBarrier functionInterleukin-1betaNatural killer cell numbersStress-induced changesPlasma interleukin-1betaHelper T cellsPeripheral blood leukocytesCytolytic T lymphocytesTransepidermal water lossClear exacerbationCytokine responsesHealthy womenInterleukin-10Exercise protocolPlasma levels
1996
Comparison of obsessions and compulsions in patients with anorexia nervosa and obsessive compulsive disorder
Bastiani A, Altemus M, Pigott T, Rubenstein C, Weltzin T, Kaye W. Comparison of obsessions and compulsions in patients with anorexia nervosa and obsessive compulsive disorder. Biological Psychiatry 1996, 39: 966-969. PMID: 9162209, DOI: 10.1016/0006-3223(95)00306-1.Peer-Reviewed Original Research
1995
Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: Relation to clinical and biochemical variable
Demitrack M, Heyes M, Altemus M, Pigott T, Gold P. Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: Relation to clinical and biochemical variable. Biological Psychiatry 1995, 37: 512-520. PMID: 7542489, DOI: 10.1016/0006-3223(94)00173-z.Peer-Reviewed Original ResearchConceptsCerebrospinal fluid levelsKynurenic acidKynurenine pathwayQuinolinic acidFluid levelsBody weightAnorexia nervosaMedication-free female patientsN-methyl-D-aspartate receptor agonistExcitatory amino acid receptorsL-kynurenineNormal weight bulimia nervosaAcid levelsQuinolinic acid levelsAmino acid receptorsKynurenic acid levelsNormal body weightNormal-weight femalesL-tryptophanEating Disorder PatientsUnderweight anorecticsUnderweight phaseEating-disordered patientsNutritional recoveryFemale patients
1994
Eating behavior in bulimia nervosa: multiple meal analyses
Hetherington M, Altemus M, Nelson M, Bernat A, Gold P. Eating behavior in bulimia nervosa: multiple meal analyses. American Journal Of Clinical Nutrition 1994, 60: 864-873. PMID: 7985626, DOI: 10.1093/ajcn/60.6.864.Peer-Reviewed Original ResearchConceptsControl subjectsBulimic patientsWeight-matched control subjectsTotal daily energy intakeDaily energy intakeImprovement of moodFrequency of bingeRatings of appetiteChaotic eating patternsFluid intakeInpatient unitEating patternsBulimia nervosaEnergy intakePatientsConsecutive daysBulimic individualsIntakeBingeSubjectsMacronutrient analysisMoodMeal analysisChanges in Cerebrospinal Fluid Neurochemistry During Treatment of Obsessive-compulsive Disorder With Clomipramine
Altemus M, Swedo S, Leonard H, Richter D, Rubinow D, Potter W, Rapoport J. Changes in Cerebrospinal Fluid Neurochemistry During Treatment of Obsessive-compulsive Disorder With Clomipramine. JAMA Psychiatry 1994, 51: 794-803. PMID: 7524463, DOI: 10.1001/archpsyc.1994.03950100042004.Peer-Reviewed Original ResearchConceptsCorticotropin-releasing hormoneLong-term treatmentObsessive-compulsive disorderCSF levelsHomovanillic acidCSF monoamine metabolite levelsCentral administrationCerebrospinal fluid levelsSignificant decreaseCSF homovanillic acidMonoamine metabolite levelsCerebrospinal fluid neurochemistryCSF oxytocin levelsOpposite behavioral effectsPharmacologic treatmentSomatostatin levelsMonoamine metabolitesPathophysiologic processesFluid levelsBehavioral effectsOxytocin levelsClomipramine hydrochlorideMetabolite levelsDisordersVasopressinPulsatility of 24-Hour Concentrations of Circulating lnterleukin-1-Alpha in Healthy Women: Analysis of Integrated Basal Levels, Discrete Pulse Properties, and Correlation with Simultaneous lnterleukin-2 Concentrations
Licinio J, Wong M, Altemus M, Bongiorno P, Bernat A, Brabant G, Tamarkin L, Gold P. Pulsatility of 24-Hour Concentrations of Circulating lnterleukin-1-Alpha in Healthy Women: Analysis of Integrated Basal Levels, Discrete Pulse Properties, and Correlation with Simultaneous lnterleukin-2 Concentrations. NeuroImmunoModulation 1994, 1: 242-250. PMID: 7489339, DOI: 10.1159/000097172.Peer-Reviewed Original ResearchConceptsIL-1 alpha concentrationsIL-1 alphaAlpha concentrationsMicrograms/IL-2IL-1 alpha levelsIL-2 levelsFollicle-stimulating hormoneHealthy female volunteersCytokine cascadeHealthy womenAlpha actsSystemic circulationFemale volunteersGrowth hormoneBasal levelsAlpha levelsHormoneDistant sitesInterpulse intervalsPulsatilityAlphaSubjectsLevelsInterleukin
1993
Relation of dissociative phenomena to levels of cerebrospinal fluid monoamine metabolites and beta-endorphin in patients with eating disorders: A pilot study
Demitrack M, Putnam F, Rubinow D, Pigott T, Altemus M, Krahn D, Gold P. Relation of dissociative phenomena to levels of cerebrospinal fluid monoamine metabolites and beta-endorphin in patients with eating disorders: A pilot study. Psychiatry Research 1993, 49: 1-10. PMID: 7511247, DOI: 10.1016/0165-1781(93)90026-d.Peer-Reviewed Original ResearchConceptsMonoamine metabolitesCerebrospinal fluid monoamine metabolitesDissociative Experiences ScaleCerebrospinal fluid levelsMajor monoamine metabolitesState-dependent memoryNeurochemical disturbancesAcute phaseOpioid systemNeurochemical changesClinical expressionFluid levelsPatientsPilot studyDisordersNeurobiologic systemsExperiences ScaleMetabolitesDissociative capacityPrevious studiesDopaminergicDissociative phenomenaIllnessCSF somatostatin in obsessive-compulsive disorder
Altemus M, Pigott T, L'Heureux F, Davis C, Rubinow D, Murphy D, Gold P. CSF somatostatin in obsessive-compulsive disorder. American Journal Of Psychiatry 1993, 150: 460-464. PMID: 8094599, DOI: 10.1176/ajp.150.3.460.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderCSF somatostatinDrug-free outpatientsSerotonin reuptake inhibitorsSpectrum of disordersSubstantial cognitive deficitsMeasurement of somatostatinPredominant symptomReuptake inhibitorsSomatostatin activitySomatostatin levelsBrain contentPatient subgroupsClinical symptomatologyNormal subjectsNormal volunteersSomatostatinPatientsNeuropharmacological agentsExperimental animalsCognitive deficitsCentral administrationDisordersFunctional significance
1992
Abnormalities in the Regulation of Vasopressin and Corticotropin Releasing Factor Secretion in Obsessive-Compulsive Disorder
Altemus M, Pigott T, Kalogeras K, Demitrack M, Dubbert B, Murphy D, Gold P. Abnormalities in the Regulation of Vasopressin and Corticotropin Releasing Factor Secretion in Obsessive-Compulsive Disorder. JAMA Psychiatry 1992, 49: 9-20. PMID: 1370198, DOI: 10.1001/archpsyc.1992.01820010009002.Peer-Reviewed Original Research
1989
Neuropsychological correlates of menstrual mood changes.
Altemus M, Wexler B, Boulis N. Neuropsychological correlates of menstrual mood changes. Psychosomatic Medicine 1989, 51: 329-336. PMID: 2734425, DOI: 10.1097/00006842-198905000-00007.Peer-Reviewed Original ResearchChanges in perceptual asymmetry with the menstrual cycle
Altemus M, Wexler B, Boulis N. Changes in perceptual asymmetry with the menstrual cycle. Neuropsychologia 1989, 27: 233-240. PMID: 2927632, DOI: 10.1016/0028-3932(89)90174-7.Peer-Reviewed Original ResearchConceptsRight ear advantageRepressive personality stylePerceptual asymmetryPersonality stylesUsual right ear advantageLanguage-related stimuliDichotic listening testPsychological featuresNeuropsychological findingsEar advantagePostmenstrual phaseMenstrual cycleListening testsStyleStimuliAsymmetryFindings