2003
Enhanced Cellular Immune Response in Women With PTSD Related to Childhood Abuse
Altemus M, Cloitre M, Dhabhar F. Enhanced Cellular Immune Response in Women With PTSD Related to Childhood Abuse. American Journal Of Psychiatry 2003, 160: 1705-1707. PMID: 12944352, DOI: 10.1176/appi.ajp.160.9.1705.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderDelayed-type hypersensitivity (DTH) skin test responsesCircadian salivary cortisol levelsHypersensitivity skin test responsesDelayed-type hypersensitivitySkin test responsesCellular immune responsesHPA axis activityCell-mediated inflammatory reactionsHealthy comparison subjectsSalivary cortisol levelsAdrenal axisSympathoadrenomedullary systemAxis activityInflammatory reactionImmune responseImmune functionPsychiatric disordersComparison subjectsCortisol levelsPlasma cortisolHistory of abuseSingle time point measurementStress disorderTime point measurements
1994
Changes in Cerebrospinal Fluid Neurochemistry During Treatment of Obsessive-compulsive Disorder With Clomipramine
Altemus M, Swedo S, Leonard H, Richter D, Rubinow D, Potter W, Rapoport J. Changes in Cerebrospinal Fluid Neurochemistry During Treatment of Obsessive-compulsive Disorder With Clomipramine. JAMA Psychiatry 1994, 51: 794-803. PMID: 7524463, DOI: 10.1001/archpsyc.1994.03950100042004.Peer-Reviewed Original ResearchConceptsCorticotropin-releasing hormoneLong-term treatmentObsessive-compulsive disorderCSF levelsHomovanillic acidCSF monoamine metabolite levelsCentral administrationCerebrospinal fluid levelsSignificant decreaseCSF homovanillic acidMonoamine metabolite levelsCerebrospinal fluid neurochemistryCSF oxytocin levelsOpposite behavioral effectsPharmacologic treatmentSomatostatin levelsMonoamine metabolitesPathophysiologic processesFluid levelsBehavioral effectsOxytocin levelsClomipramine hydrochlorideMetabolite levelsDisordersVasopressin