2005
Sex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression
Roca C, Schmidt P, Deuster P, Danaceau M, Altemus M, Putnam K, Chrousos G, Nieman L, Rubinow D. Sex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression. The Journal Of Clinical Endocrinology & Metabolism 2005, 90: 4224-4231. PMID: 15886244, DOI: 10.1210/jc.2004-2525.Peer-Reviewed Original ResearchConceptsSex-related differencesGonadal suppressionReproductive steroid levelsHypogonadal conditionsAdrenal axisSteroid levelsCortisol-binding globulin levelsCRH stimulation testSex differencesHPA axis measuresHPA axis responseMain outcome measuresHPA axis activityMiddle-aged menFemale normal volunteersLeuprolide injectionACTH ratioCRH stimulationOutpatient clinicStimulation testLeuprolide acetateTime of testingAdrenal responsivityAxis activityGlobulin levels
2004
HPA axis activation in major depression and response to fluoxetine: a pilot study
Young E, Altemus M, Lopez J, Kocsis J, Schatzberg A, deBattista C, Zubieta J. HPA axis activation in major depression and response to fluoxetine: a pilot study. Psychoneuroendocrinology 2004, 29: 1198-1204. PMID: 15219644, DOI: 10.1016/j.psyneuen.2004.02.002.Peer-Reviewed Original ResearchConceptsHPA axis activationMetyrapone challengeOnset of treatmentAxis activationMajor depressionHPA axisHamilton Depression Rating Scale ratingsOpen-label treatmentHPA axis dysregulationAdrenal axis activationPremenopausal womenLabel treatmentACTH levelsHormonal contraceptivesMedical illnessACTH secretionAxis dysregulationNormal womenDepressed patientsFluoxetine respondersDepressed womenNormal subjectsAxis IGreater severityFluoxetinePuberty, Ovarian Steroids, and Stress
YOUNG E, ALTEMUS M. Puberty, Ovarian Steroids, and Stress. Annals Of The New York Academy Of Sciences 2004, 1021: 124-133. PMID: 15251881, DOI: 10.1196/annals.1308.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFemaleGlucocorticoidsHumansHypothalamo-Hypophyseal SystemOvaryPituitary-Adrenal SystemPubertySex CharacteristicsSteroidsStress, PhysiologicalConceptsStressful life eventsMajor depressionDepressed womenPostmenopausal depressed womenReproductive hormonal changesLife eventsNormal progesteronePremenopausal womenCommon etiologyOvarian hormonesOvarian steroidsHPA axisAdrenal axisNormal womenLow estradiolFirst episodeDepressed menHormonal changesBaseline cortisolEstradiolInhibitory feedbackPubertyYoung adulthoodWomenDepression
2003
Differential Menstrual Cycle Regulation of Hypothalamic-Pituitary-Adrenal Axis in Women with Premenstrual Syndrome and Controls
Roca C, Schmidt P, Altemus M, Deuster P, Danaceau M, Putnam K, Rubinow D. Differential Menstrual Cycle Regulation of Hypothalamic-Pituitary-Adrenal Axis in Women with Premenstrual Syndrome and Controls. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 3057-3063. PMID: 12843143, DOI: 10.1210/jc.2002-021570.Peer-Reviewed Original ResearchConceptsHPA axis responsePremenstrual syndromeAdrenal axisControl womenMajor depressionLuteal phaseReproductive steroidsAxis responseTreadmill exercise stress testingHPA axis modulationMenstrual cycle regulationHPA axis abnormalitiesExercise stress testingHPA axis regulationStress testingMenstrual cycle phaseAxis abnormalitiesHPA axisMenstrual cycleGonadal steroidsAbnormal responseAxis regulationAffective disordersAffective symptomsPotent modulator
2001
Variable foraging demand rearing: sustained elevations in cisternal cerebrospinal fluid corticotropin-releasing factor concentrations in adult primates
Coplan J, Smith E, Altemus M, Scharf B, Owens M, Nemeroff C, Gorman J, Rosenblum L. Variable foraging demand rearing: sustained elevations in cisternal cerebrospinal fluid corticotropin-releasing factor concentrations in adult primates. Biological Psychiatry 2001, 50: 200-204. PMID: 11513819, DOI: 10.1016/s0006-3223(01)01175-1.Peer-Reviewed Original ResearchConceptsCerebrospinal fluid corticotropin-releasing factor concentrationsCorticotropin-releasing factor concentrationsFactor concentrationsCSF CRFAdult primatesYoung adult primatesYoung adulthoodCisternal CSF samplesCSF samplesCRF functionControl groupCRF valuesSignificant positive correlationAd libitumPresent studyJuvenile primatesPositive correlationAdulthoodPrimatesCRFElevationAbnormalities in response to vasopressin infusion in chronic fatigue syndrome
Altemus M, Dale J, Michelson D, Demitrack M, Gold P, Straus S. Abnormalities in response to vasopressin infusion in chronic fatigue syndrome. Psychoneuroendocrinology 2001, 26: 175-188. PMID: 11087963, DOI: 10.1016/s0306-4530(00)00044-5.Peer-Reviewed Original ResearchConceptsChronic fatigue syndromeCorticotropin-releasing hormoneHypothalamic CRH secretionFatigue syndromeCRH secretionACTH responseVasopressin infusionCortisol responsePeripheral infusionHour infusionACTH secretionNeuroendocrine abnormalitiesAdrenal axisHypothalamic secretionHypothalamus actsHealthy volunteersPrimary symptomsNeuroendocrine studiesArginine vasopressinInfusionSyndromePatientsSecretionVasopressinAbnormalitiesChapter 17 Neuroendocrine and emotional changes in the post-partum period
Carter C, Altemus M, Pchrousos G. Chapter 17 Neuroendocrine and emotional changes in the post-partum period. Progress In Brain Research 2001, 133: 241-249. PMID: 11589134, DOI: 10.1016/s0079-6123(01)33018-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEmotionsFemaleHumansHypothalamo-Hypophyseal SystemLactationNeuropeptidesNeurosecretory SystemsPituitary-Adrenal SystemPostpartum PeriodPregnancyConceptsPost-partum periodCorticotrophin-releasing hormoneAdrenal axisBehavioral effectsAdrenal stress axisCentral behavioral effectsPost-partum womenPowerful regulatory effectsFemale reproductive systemOptimal maternal careBrain levelsHigher bloodImmune systemExperimental animalsActive hormoneCentral mechanismsHormoneMaternal careReproductive systemNeuropeptide hormoneRegulatory effectsMood statesIntegrative functionsNeuropeptidesOxytocin
1996
Naloxone-Induced Pituitary-Adrenal Activation Does Not Differ in Patients with Depression, Obsessive Compulsive Disorder, and Healthy Controls
Michelson D, Altemus M, Galliven E, Hill L, Greenberg B, Gold P. Naloxone-Induced Pituitary-Adrenal Activation Does Not Differ in Patients with Depression, Obsessive Compulsive Disorder, and Healthy Controls. Neuropsychopharmacology 1996, 15: 207-212. PMID: 8840357, DOI: 10.1016/0893-133x(95)00210-5.Peer-Reviewed Original ResearchConceptsHypothalamic CRH neuronsAdrenocorticotropic hormoneCRH neuronsCortisol secretionElevated urinary free cortisolHypothalamic CRH releaseUrinary free cortisolOpiate antagonist naloxoneEvidence of dysregulationPituitary-adrenal activationAdrenal studiesCRH releaseHormone neuronsAntagonist naloxoneHPA axisObsessive-compulsive disorderDepressed patientsHealthy controlsHypothalamic corticotropinRandomized fashionCentral stimulantsNaloxoneSeparate daysPatientsPsychiatric controls
1995
Neuropeptides in Anxiety Disorders
ALTEMUS M. Neuropeptides in Anxiety Disorders. Annals Of The New York Academy Of Sciences 1995, 771: 697-707. PMID: 8597442, DOI: 10.1111/j.1749-6632.1995.tb44721.x.Peer-Reviewed Original ResearchSuppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women
Altemus M, Deuster P, Galliven E, Carter C, Gold P. Suppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women. The Journal Of Clinical Endocrinology & Metabolism 1995, 80: 2954-2959. PMID: 7559880, DOI: 10.1210/jcem.80.10.7559880.Peer-Reviewed Original ResearchConceptsNeurohormonal systemsTreadmill exerciseBasal norepinephrine levelsIntensity-dependent activationAdrenal axis responseMin of exerciseMaximal oxygen uptakeSympathomedullary systemNorepinephrine levelsBreast feedingPlasma ACTHAdrenal axisNonlactating womenWeeks postpartumAxis responseGlucose responseWomenPhysical conditioningOxygen uptakeExerciseSubjectsPhysiological responsesResponseACTHPostpartum
1994
Increased mRNA for corticotrophin releasing hormone in the amygdala of Fawn‐hooded rats: A potential animal model of anxiety
Altemus M, Smith M, Diep V, Aulakh C, Murphy D. Increased mRNA for corticotrophin releasing hormone in the amygdala of Fawn‐hooded rats: A potential animal model of anxiety. Anxiety 1994, 1: 251-257. PMID: 9160583, DOI: 10.1002/anxi.3070010602.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaAnimalsAnxiety DisordersArousalCorticosteroneCorticotropin-Releasing HormoneDisease Models, AnimalHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemRatsRats, Inbred StrainsRats, WistarReceptors, GlucocorticoidReceptors, MineralocorticoidRNA, MessengerSpecies SpecificityTyrosine 3-MonooxygenaseConceptsFawn-Hooded ratsAdrenal axis activityBasal corticosterone levelsParaventricular nucleusCRH mRNAAdrenal weightAxis activityWistar ratsReceptor mRNACorticosterone levelsArginine vasopressinRat strainsCentral nucleusAdult-onset hypertensionFawn-hooded strainFawn-hooded rat strainMineralocorticoid receptor mRNAUrinary catecholamine levelsHypothalamic paraventricular nucleusGlucocorticoid receptor mRNAWistar rat strainPotential animal modelTyrosine hydroxylase mRNAMore freezing behaviorAVP mRNA expression