2004
HPA axis activation in major depression and response to fluoxetine: a pilot study
Young E, Altemus M, Lopez J, Kocsis J, Schatzberg A, deBattista C, Zubieta J. HPA axis activation in major depression and response to fluoxetine: a pilot study. Psychoneuroendocrinology 2004, 29: 1198-1204. PMID: 15219644, DOI: 10.1016/j.psyneuen.2004.02.002.Peer-Reviewed Original ResearchConceptsHPA axis activationMetyrapone challengeOnset of treatmentAxis activationMajor depressionHPA axisHamilton Depression Rating Scale ratingsOpen-label treatmentHPA axis dysregulationAdrenal axis activationPremenopausal womenLabel treatmentACTH levelsHormonal contraceptivesMedical illnessACTH secretionAxis dysregulationNormal womenDepressed patientsFluoxetine respondersDepressed womenNormal subjectsAxis IGreater severityFluoxetine
1998
Delayed obsessive-compulsive disorder symptom exacerbation after a single dose of a serotonin antagonist in fluoxetine-treated but not untreated patients
Greenberg B, Benjamin J, Martin J, Keuler D, Huang S, Altemus M, Murphy D. Delayed obsessive-compulsive disorder symptom exacerbation after a single dose of a serotonin antagonist in fluoxetine-treated but not untreated patients. Psychopharmacology 1998, 140: 434-444. PMID: 9888619, DOI: 10.1007/s002130050787.Peer-Reviewed Original ResearchConceptsFluoxetine-treated patientsObsessive-compulsive disorderUnmedicated patientsAdministration of metergolineSerotonin reuptake inhibitorsUnderlie symptomsUntreated patientsBrain serotoninReuptake inhibitorsSerotonin antagonistsSerotonergic transmissionSingle doseSymptom exacerbationReceptor responsivityTherapeutic effectMetergolinePatientsPlaceboSymptom ratingsSymptomsSuch treatmentSerotoninDisordersPilot resultsDays
1993
Relation of dissociative phenomena to levels of cerebrospinal fluid monoamine metabolites and beta-endorphin in patients with eating disorders: A pilot study
Demitrack M, Putnam F, Rubinow D, Pigott T, Altemus M, Krahn D, Gold P. Relation of dissociative phenomena to levels of cerebrospinal fluid monoamine metabolites and beta-endorphin in patients with eating disorders: A pilot study. Psychiatry Research 1993, 49: 1-10. PMID: 7511247, DOI: 10.1016/0165-1781(93)90026-d.Peer-Reviewed Original ResearchConceptsMonoamine metabolitesCerebrospinal fluid monoamine metabolitesDissociative Experiences ScaleCerebrospinal fluid levelsMajor monoamine metabolitesState-dependent memoryNeurochemical disturbancesAcute phaseOpioid systemNeurochemical changesClinical expressionFluid levelsPatientsPilot studyDisordersNeurobiologic systemsExperiences ScaleMetabolitesDissociative capacityPrevious studiesDopaminergicDissociative phenomenaIllness