2005
Synchronized Maternal-Infant Elevations of Primate CSF CRF Concentrations in Response to Variable Foraging Demand
Coplan J, Altemus M, Mathew S, Smith E, Sharf B, Coplan P, Kral J, Gorman J, Owens M, Nemeroff C, Rosenblum L. Synchronized Maternal-Infant Elevations of Primate CSF CRF Concentrations in Response to Variable Foraging Demand. CNS Spectrums 2005, 10: 530-536. PMID: 16155510, DOI: 10.1017/s109285290001018x.Peer-Reviewed Original ResearchConceptsCentral corticotropin-releasing factorCSF CRF concentrationsCRF concentrationsCentral CRF systemCorticotropin-releasing factorSignificant mean increaseCerebrospinal fluid samplesEarly life stressorsVFD conditionsInfant sex differencesEnvironment-gene interactionsCRF levelsCRF expressionPsychiatric disordersCRF responseCRF systemInfant's lifeMean increaseDays postpartumInfantsStudy periodFluid samplesMothersMaternal responsivitySex differencesSex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression
Roca C, Schmidt P, Deuster P, Danaceau M, Altemus M, Putnam K, Chrousos G, Nieman L, Rubinow D. Sex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression. The Journal Of Clinical Endocrinology & Metabolism 2005, 90: 4224-4231. PMID: 15886244, DOI: 10.1210/jc.2004-2525.Peer-Reviewed Original ResearchConceptsSex-related differencesGonadal suppressionReproductive steroid levelsHypogonadal conditionsAdrenal axisSteroid levelsCortisol-binding globulin levelsCRH stimulation testSex differencesHPA axis measuresHPA axis responseMain outcome measuresHPA axis activityMiddle-aged menFemale normal volunteersLeuprolide injectionACTH ratioCRH stimulationOutpatient clinicStimulation testLeuprolide acetateTime of testingAdrenal responsivityAxis activityGlobulin levels
2001
Effects of Estrogen Antagonists and Agonists on the ACTH Response to Restraint Stress in Female Rats
Young E, Altemus M, Parkison V, Shastry S. Effects of Estrogen Antagonists and Agonists on the ACTH Response to Restraint Stress in Female Rats. Neuropsychopharmacology 2001, 25: 881-891. PMID: 11750181, DOI: 10.1016/s0893-133x(01)00301-3.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAnimalsAnti-Inflammatory AgentsCorticosteroneDrug ImplantsEstradiolEstrogen AntagonistsEstrogensFeedbackFemaleGlucocorticoidsHypothalamo-Hypophyseal SystemMaleNitromifeneOvariectomyProgesteroneRatsRats, Sprague-DawleyRestraint, PhysicalStress, PsychologicalTamoxifenConceptsRestraint stressACTH responseCorticosterone responseFemale ratsDays of estradiolLow-dose estradiolExogenous glucocorticoid administrationEstrogen antagonist tamoxifenCombination of estradiolAdrenal stress responseImportant inhibitory factorProgesterone replacementDose estradiolGlucocorticoid administrationEstrogen contributesAntagonist tamoxifenEstrogen antagonistEstradiol treatmentACTHInhibitory factorEstradiolRatsTamoxifenProgesteroneSex differences