2004
HPA axis activation in major depression and response to fluoxetine: a pilot study
Young E, Altemus M, Lopez J, Kocsis J, Schatzberg A, deBattista C, Zubieta J. HPA axis activation in major depression and response to fluoxetine: a pilot study. Psychoneuroendocrinology 2004, 29: 1198-1204. PMID: 15219644, DOI: 10.1016/j.psyneuen.2004.02.002.Peer-Reviewed Original ResearchConceptsHPA axis activationMetyrapone challengeOnset of treatmentAxis activationMajor depressionHPA axisHamilton Depression Rating Scale ratingsOpen-label treatmentHPA axis dysregulationAdrenal axis activationPremenopausal womenLabel treatmentACTH levelsHormonal contraceptivesMedical illnessACTH secretionAxis dysregulationNormal womenDepressed patientsFluoxetine respondersDepressed womenNormal subjectsAxis IGreater severityFluoxetinePuberty, Ovarian Steroids, and Stress
YOUNG E, ALTEMUS M. Puberty, Ovarian Steroids, and Stress. Annals Of The New York Academy Of Sciences 2004, 1021: 124-133. PMID: 15251881, DOI: 10.1196/annals.1308.013.Peer-Reviewed Original ResearchConceptsStressful life eventsMajor depressionDepressed womenPostmenopausal depressed womenReproductive hormonal changesLife eventsNormal progesteronePremenopausal womenCommon etiologyOvarian hormonesOvarian steroidsHPA axisAdrenal axisNormal womenLow estradiolFirst episodeDepressed menHormonal changesBaseline cortisolEstradiolInhibitory feedbackPubertyYoung adulthoodWomenDepression
1995
Symptom overlap between OCD and bulimia nervosa
Rubenstein C, Altemus M, Pigott T, Hess A, Murphy D. Symptom overlap between OCD and bulimia nervosa. Journal Of Anxiety Disorders 1995, 9: 1-9. DOI: 10.1016/0887-6185(95)91551-r.Peer-Reviewed Original ResearchObsessive-compulsive disorderBulimic patientsOCD patientsNormal volunteersBulimia nervosaFemale bulimia nervosa patientsSCL-90Hamilton Depression Rating ScoreDepression rating scoresEffective nonpharmacological treatmentBulimia nervosa patientsInpatient treatment programFemale OCD patientsMeasures of depressionNonpharmacological treatmentsNormal womenNervosa patientsNormal controlsDepression subscalePsychiatric disordersPatientsSymptom overlapTreatment programSignificant decreaseBulimia subscale