2005
Sex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression
Roca C, Schmidt P, Deuster P, Danaceau M, Altemus M, Putnam K, Chrousos G, Nieman L, Rubinow D. Sex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression. The Journal Of Clinical Endocrinology & Metabolism 2005, 90: 4224-4231. PMID: 15886244, DOI: 10.1210/jc.2004-2525.Peer-Reviewed Original ResearchConceptsSex-related differencesGonadal suppressionReproductive steroid levelsHypogonadal conditionsAdrenal axisSteroid levelsCortisol-binding globulin levelsCRH stimulation testSex differencesHPA axis measuresHPA axis responseMain outcome measuresHPA axis activityMiddle-aged menFemale normal volunteersLeuprolide injectionACTH ratioCRH stimulationOutpatient clinicStimulation testLeuprolide acetateTime of testingAdrenal responsivityAxis activityGlobulin levels
2003
Enhanced Cellular Immune Response in Women With PTSD Related to Childhood Abuse
Altemus M, Cloitre M, Dhabhar F. Enhanced Cellular Immune Response in Women With PTSD Related to Childhood Abuse. American Journal Of Psychiatry 2003, 160: 1705-1707. PMID: 12944352, DOI: 10.1176/appi.ajp.160.9.1705.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderDelayed-type hypersensitivity (DTH) skin test responsesCircadian salivary cortisol levelsHypersensitivity skin test responsesDelayed-type hypersensitivitySkin test responsesCellular immune responsesHPA axis activityCell-mediated inflammatory reactionsHealthy comparison subjectsSalivary cortisol levelsAdrenal axisSympathoadrenomedullary systemAxis activityInflammatory reactionImmune responseImmune functionPsychiatric disordersComparison subjectsCortisol levelsPlasma cortisolHistory of abuseSingle time point measurementStress disorderTime point measurements