2006
The Biological Underpinnings of Depression
Korszun A, Altemus M, Young E. The Biological Underpinnings of Depression. 2006, 41-61. DOI: 10.1017/cbo9780511841262.005.Peer-Reviewed Original ResearchAdrenocorticotropic hormoneDepressive disorderHypothalamic pituitary adrenal axisAnterior pituitary corticotropesPituitary-adrenal axisDevelopment of depressionCases of depressionStress-related conditionsGlucocorticoid feedbackPituitary siteAdrenal axisHPA axisCortisol secretionExaggerated responseAdrenal glucocorticoidsPituitary corticotropesHormonal systemsDepressionGenetic vulnerabilityComplex dynamic equilibriumBiological underpinningsCentral effectorIntroduction StressExtrinsic stressorsLife events
1997
Reduced Sensitivity to Glucocorticoid Feedback and Reduced Glucocorticoid Receptor mRNA Expression in the Luteal Phase of the Menstrual Cycle
Altemus M, Redwine L, Leong Y, Yoshikawa T, Yehuda R, Detera-Wadleigh S, Murphy D. Reduced Sensitivity to Glucocorticoid Feedback and Reduced Glucocorticoid Receptor mRNA Expression in the Luteal Phase of the Menstrual Cycle. Neuropsychopharmacology 1997, 17: 100-109. PMID: 9252985, DOI: 10.1016/s0893-133x(97)00039-0.Peer-Reviewed Original ResearchConceptsMid-luteal phaseGlucocorticoid receptor mRNA expressionReceptor mRNA expressionMenstrual cycleMRNA expressionFollicular phaseCommon premenstrual symptomsGlucocorticoid feedback regulationCentral stress response systemAdrenal axis regulationHypothalamic pituitary adrenal (HPA) axis regulationPlasma cortisol responseGlucocorticoid feedbackHealthy womenAdrenal axisDexamethasone suppressionLuteal phasePsychiatric illnessAxis regulationPremenstrual symptomsCortisol responsePlasma cortisolStress response systemFeedback regulationLymphocytes