2004
HPA axis activation in major depression and response to fluoxetine: a pilot study
Young E, Altemus M, Lopez J, Kocsis J, Schatzberg A, deBattista C, Zubieta J. HPA axis activation in major depression and response to fluoxetine: a pilot study. Psychoneuroendocrinology 2004, 29: 1198-1204. PMID: 15219644, DOI: 10.1016/j.psyneuen.2004.02.002.Peer-Reviewed Original ResearchConceptsHPA axis activationMetyrapone challengeOnset of treatmentAxis activationMajor depressionHPA axisHamilton Depression Rating Scale ratingsOpen-label treatmentHPA axis dysregulationAdrenal axis activationPremenopausal womenLabel treatmentACTH levelsHormonal contraceptivesMedical illnessACTH secretionAxis dysregulationNormal womenDepressed patientsFluoxetine respondersDepressed womenNormal subjectsAxis IGreater severityFluoxetine
1996
Naloxone-Induced Pituitary-Adrenal Activation Does Not Differ in Patients with Depression, Obsessive Compulsive Disorder, and Healthy Controls
Michelson D, Altemus M, Galliven E, Hill L, Greenberg B, Gold P. Naloxone-Induced Pituitary-Adrenal Activation Does Not Differ in Patients with Depression, Obsessive Compulsive Disorder, and Healthy Controls. Neuropsychopharmacology 1996, 15: 207-212. PMID: 8840357, DOI: 10.1016/0893-133x(95)00210-5.Peer-Reviewed Original ResearchConceptsHypothalamic CRH neuronsAdrenocorticotropic hormoneCRH neuronsCortisol secretionElevated urinary free cortisolHypothalamic CRH releaseUrinary free cortisolOpiate antagonist naloxoneEvidence of dysregulationPituitary-adrenal activationAdrenal studiesCRH releaseHormone neuronsAntagonist naloxoneHPA axisObsessive-compulsive disorderDepressed patientsHealthy controlsHypothalamic corticotropinRandomized fashionCentral stimulantsNaloxoneSeparate daysPatientsPsychiatric controls