2005
Synchronized Maternal-Infant Elevations of Primate CSF CRF Concentrations in Response to Variable Foraging Demand
Coplan J, Altemus M, Mathew S, Smith E, Sharf B, Coplan P, Kral J, Gorman J, Owens M, Nemeroff C, Rosenblum L. Synchronized Maternal-Infant Elevations of Primate CSF CRF Concentrations in Response to Variable Foraging Demand. CNS Spectrums 2005, 10: 530-536. PMID: 16155510, DOI: 10.1017/s109285290001018x.Peer-Reviewed Original ResearchConceptsCentral corticotropin-releasing factorCSF CRF concentrationsCRF concentrationsCentral CRF systemCorticotropin-releasing factorSignificant mean increaseCerebrospinal fluid samplesEarly life stressorsVFD conditionsInfant sex differencesEnvironment-gene interactionsCRF levelsCRF expressionPsychiatric disordersCRF responseCRF systemInfant's lifeMean increaseDays postpartumInfantsStudy periodFluid samplesMothersMaternal responsivitySex differences
2000
Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations
Coplan J, Smith E, Trost R, Scharf B, Altemus M, Bjornson L, Owens M, Gorman J, Nemeroff C, Rosenblum L. Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations. Psychiatry Research 2000, 95: 93-102. PMID: 10963795, DOI: 10.1016/s0165-1781(00)00173-6.Peer-Reviewed Original ResearchConceptsCSF CRF concentrationsVariable foraging demandGrowth hormone responseGH responseCRF concentrationsCerebrospinal fluid corticotropin-releasing factor concentrationsHormone responseCorticotropin-releasing factor concentrationsAdult primatesDosage of clonidineYoung adult primatesAdrenergic agonist clonidineCorticotropin-releasing factorAgonist clonidineNeuroendocrine abnormalitiesPersistent elevationPrevious primate studiesGH releaseGH-like immunoreactivitySignificant inverse relationshipKetamine anesthesiaClonidineCRF activityHuman patientsFactor concentrations