HPA axis activation in major depression and response to fluoxetine: a pilot study
Young E, Altemus M, Lopez J, Kocsis J, Schatzberg A, deBattista C, Zubieta J. HPA axis activation in major depression and response to fluoxetine: a pilot study. Psychoneuroendocrinology 2004, 29: 1198-1204. PMID: 15219644, DOI: 10.1016/j.psyneuen.2004.02.002.Peer-Reviewed Original ResearchConceptsHPA axis activationMetyrapone challengeOnset of treatmentAxis activationMajor depressionHPA axisHamilton Depression Rating Scale ratingsOpen-label treatmentHPA axis dysregulationAdrenal axis activationPremenopausal womenLabel treatmentACTH levelsHormonal contraceptivesMedical illnessACTH secretionAxis dysregulationNormal womenDepressed patientsFluoxetine respondersDepressed womenNormal subjectsAxis IGreater severityFluoxetine