2024
POST-GWAS FOR PTSD: FROM RISK LOCI TO BIOLOGICAL MEANING
Nievergelt C, Ongeri L, Gelernter J. POST-GWAS FOR PTSD: FROM RISK LOCI TO BIOLOGICAL MEANING. European Neuropsychopharmacology 2024, 87: 2-3. DOI: 10.1016/j.euroneuro.2024.08.013.Peer-Reviewed Original ResearchPosttraumatic stress disorderPGC-PTSDLocal ancestry inferencePTSD associationsRisk lociPosttraumatic stress disorder casenessThreat-related processingGenome-wide association study resultsCo-morbid disordersComplex patterns of admixtureStress-related disordersMental health disordersPatterns of admixturePotential causal genesMajor histocompatibility complexMental health consequencesAssociation study resultsMDD patientsMulti-omics approachStress disorderMulti-omics studiesHuman leukocyte antigenAncestry inferenceAdmixed individualsMDD
2022
Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits
Pathak GA, Singh K, Wendt FR, Fleming TW, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O’ Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, Davis LK, Polimanti R. Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits. Molecular Psychiatry 2022, 27: 1394-1404. PMID: 35241783, PMCID: PMC9210390, DOI: 10.1038/s41380-022-01488-9.Peer-Reviewed Original ResearchConceptsLocal genetic correlationsCell type-specific expressionVanderbilt University biorepositoryMulti-omics studiesMulti-omics investigationsDorsolateral prefrontal cortex tissueGenomic evidenceLaboratory traitsSpecific expressionCardio-metabolic traitsMillion Veteran ProgramPrefrontal cortex tissueMiR-148GenesGenetic correlationsRegulatory profileTraitsProtein expressionCardiometabolic traitsExpressionVeteran ProgramCortex tissueBiological heterogeneitySplicingPrioritization approach