- Lecturers & Adjunct
Assistant Professor of PharmacologyOur lab uses multidisciplinary approaches to understand the impact of RNA metabolism in development, health and disease. We are primarily focused in identifying the physiological and pathophysiological roles of RNA modifications and non-coding RNAs at the molecular, cellular and organismal levels. Claudio, a native of Chile, obtained his Ph.D. from Cornell University in NYC. He was a postdoctoral fellow at the Rockefeller University before joining Yale University in 2017.
Professor of Pharmacology and of Molecular Biophysics and Biochemistry; Co-Leader, Developmental Therapeutics, Yale Cancer Center; Co-Director Therapeutics/Chemotherapy ProgramKaren S. Anderson is a Professor of Pharmacology and Molecular Biophysics and Biochemistry. She is involved in teaching undergraduates and graduate students about drug discovery and structure-based drug design. She also serves as an undergraduate research mentor and is a fellow at Pierson College at Yale serving as a undergraduate freshman advisor. Dr. Anderson's research utilizes mechanistic enzymology and structure-based drug design. Her work focuses on understanding how enzymes, playing critical roles in such diseases as cancer and infectious diseases, including AIDS, work at a molecular level. She uses that information to develop new drug therapies. She has trained over 50 undergraduates, graduate students, M.D./Ph.D. students and postdoctoral students who have gone on to graduate school and medical school as well as successful careers in academia and industry and who are involved in biomedical research.
Assistant Professor of PharmacologyThe Bhattacharyya Lab studies molecular mechanism of kinase signaling, especially in the context of learning, memory and neuropathological conditions. Dr. Bhattacharyya received her PhD in Computational Biophysics at the Indian Institute of Science, Bangalore where she used molecular dynamics simulations and graph theory to study allosteric communication in proteins and its complexes with RNA/DNA. She made a transition into experimental biology during her postdoctoral studies at the University of California Berkeley as a Human Frontier Science Program Long Term Fellow. She used structural biology, single-molecule microscopy, and native mass spectrometry along with computational techniques to study the molecular mechanism of regulation in a calcium/calmodulin-dependent protein kinase that is critical for learning and memory. The Bhattacharyya Lab takes an integrative approach to understand the molecular mechanism of cellular signaling using both experimental and computational techniques.
Associate Professor of Pharmacology and of Molecular Biophysics and BiochemistryDr. Boggon is a structural biologist interested in the molecular basis of cytosolic signal transduction cascades. He completed his Ph.D. at the University of Manchester, U.K., and postdoctoral studies at Mount Sinai School of Medicine, Columbia University and the Dana-Farber Cancer Institute (at Harvard Medical School). His lab is interested in understanding how RhoGTPase signal transduction pathways are regulated at the molecular level, and the molecular basis for acquisition of cerebrovascular disorders.
Assistant Professor of PharmacologyJoel received his undergraduate degree from the University of Alberta, Canada, and his Ph.D. from Columbia University. He received postdoctoral training in the MacKinnon and Ruta Laboratories at The Rockefeller University before joining the Department of Pharmacology at Yale in 2020. As a postdoc, Joel used single-particle cryo-electron microscopy to determine the first high-resolution structure of an olfactory receptor, the insect Orco. At Yale, Joel is continuing to study smell and taste receptors to elucidate the elementary principles of chemosensory detection.
Henry Bronson Professor of Pharmacology; Chairman, Consortium for the Globalization of Chinese Medicine (CGCM)The Cheng laboratory studies the action of antiviral drugs against HBV, HIV, EBV, and HCV, as well as the discovery of antivirals with unique mode of action against those viruses.
Eugene Higgins Professor of Chemistry and Professor of PharmacologyJon was born and raised near Los Angeles and received his B.S. degree at MIT and his Ph.D. degree from Harvard University. He was a postdoctoral fellow at the University of California at Berkeley and subsequently joined the faculty at the same institution. Prior to coming to Yale University, he was Professor in the Department of Chemistry at UC Berkeley and jointly held a faculty position in the Department of Cellular and Molecular Pharmacology at UC San Francisco. He has published more than 290 research articles on the application of chemistry to biomedical research.
Associate Professor of Pharmacology; Member, Yale Cancer Biology InstituteDr. Ferguson’s research focuses on extracellular control of receptor tyrosine kinases (RTKs), aberrant activation of which can drive cancer and other diseases. Dr. Ferguson obtained her Ph.D. from Yale in 1996, and completed postdoctoral training at the University of Pennsylvania Perelman School of Medicine. She transitioned to an independent faculty position in the Department of Physiology at UPenn in 2003, returning to Connecticut in 2015 to join the Yale Cancer Biology Institute and Department of Pharmacology.
Professor of Pharmacology and of Cellular And Molecular PhysiologyDr. Kaczmarek carried out his undergraduate and graduate work at the University of London. He continued his research career at the University of California Los Angeles (where he learned electrophysiology), the Free University of Brussels, Belgium (where he learned how to make neural network models) and the California Institute of Technology (where he made the fundamental discovery that phosphorylation state changes ionic currents) before joining the Yale faculty in 1981. The Kaczmarek group studies biochemical changes in neurons that result in prolonged changes in the behavior of an animal or detect specific patterns of sensory inputs. He is well-known for discovering the genes for several ion channel proteins that are directly responsible for the excitability of nerve cells. His work was the first to demonstrate directly that rapid changes in phosphorylation state of ion channels occur in vivo in response to changes in the animal’s environment. Currently his lab is focused on the way mutations in these proteins may be responsible for several forms of intellectual disability and autism. He has been very fortunate to have many exceptionally talented pre- and postdoctoral trainees in his laboratory. Thirty-two of the students and postdocs from the Kaczmarek laboratory have gone on to hold tenure-track faculty positions at major institutions including Brown University, Yale University, UCSF, UCSD, Vanderbilt and many more.
Alfred Gilman Professor of Pharmacology; Deputy Director, Yale Cancer Center; Co-director, Cancer Biology InstituteMark Lemmon, PhD, FRS is the Alfred Gilman Professor of Pharmacology, Deputy Director of Yale Cancer Center, and Co-Director of Yale Cancer Biology Institute. He returned to Yale as the David A. Sackler Professor of Pharmacology in 2015 after 19 years on the faculty at the University of Pennsylvania’s Perelman School of Medicine. At Penn, he was the George W. Raiziss Professor of Biochemistry and Biophysics as well as Chair of the department and an Investigator at the Abramson Family Cancer Research Institute. Dr. Lemmon was elected as a Fellow of the Royal Society (the UK's national academy) in 2016, and has been honored with the Dorothy Crowfoot Hodgkin Award of the Protein Society and the Stanley N. Cohen Biomedical Research Award from the University of Pennsylvania. He is on the Editorial Advisory Boards of several journals, including Cell and Molecular Cell, and is Chair of the Editorial Board of the Biochemical Journal.Dr. Lemmon’s research focuses on understanding the signaling networks controlled by receptor tyrosine kinase (RTK) growth factors that, when mutated, cause cancers and other diseases. His laboratory combines biochemical, structural, biophysical, and cellular approaches to investigate how these networks function, and also collaborates with clinical groups to apply the mechanistic lessons learned to inhibitor choice and combating development of resistance to targeted therapies in the clinic.
Assistant Professor of PharmacologyDr. Liu received his PhD of Biomedical Sciences at Shanghai Institute for Biological Sciences, Chinese Academy of Sciences. Dr. Liu completed a post-doctoral research fellowship (May 2011 - October 2017) in the Proteomics Laboratory of Dr. Ruedi Aebersold in the Institute of Molecular Systems Biology, ETH Zurich, Switzerland. Dr. Liu joined Yale Cancer Biology Institute as an Assistant Professor of Pharmacology in December 2017. His research group at Yale aims to contribute to the development of Data independent acquisition (DIA) mass spectrometry and other proteomic techniques and their applications in Cancer Biology and Systems Biology studies.
Professor of Pharmacology; Faculty Director, Office of Postdoctoral Affairs; Director of Graduate Studies, PharmacologyElias Lolis was trained in structural biology earning his PhD in Chemistry from MIT and, as a postdoctoral associate at the Laboratory of Medical Biochemistry at Rockefeller University studying the functional interaction between advanced glycation end products (AGEs) and the immune system. He currently studies chemokines, macrophage migration inhibitory factor (MIF family of proteins), and their receptors in disease (cancer, inflammation, and infection) using techniques ranging from structural biology, Crispr/Cas9 gene editing in mouse models of disease, and high throughput screening of small molecules and biotherapeutics. He has national and international collaborations on phosphatases, proteins of SARS-CoV-2, and MIF. He received a Pharmaceutical Manufacturers Association Faculty Development Award in Basic Pharmacology, the Donaghue Young Investigator Award, and the GlaxoWellcome Award in Drug Discovery. He is the founder and co-founder of the Macromolecular X-ray Core Facility and Yale Keck Bioinformatics Resource, respectively. He trained 25 PhDs and postdoctoral associates, two postgrads, seven Yale undergraduates, ten under-represented minority summer students (BioStep and PREP), and 22 undergraduates and high school students from various schools. He currently serves as the Faculty Director of the Office of Postdoctoral Affairs for Yale University and the Director of Graduate Studies for the Department of Pharmacology.
Assistant Professor of PharmacologyWei Mi obtained his PhD degree in structural biology at Peking University, Beijing, China. Fascinated by structures of membrane proteins, he came to the US and received postdoctoral training at Purdue University, the University of Washington and Harvard Medical School (HMS). At HMS, he joined the laboratory of Dr. Maofu Liao and used single particle cryo-electron microscopy (Cryo-EM) to determine structures of ATP-binding cassette transporters in lipid bilayer environment. In 2019, Dr Mi joined the Department of Pharmacology at Yale University School of Medicine. The focus of his research is to dissect mechanisms of membrane proteins with biochemical and structural approaches.