Assaf Alon, PhD
Assistant Professor of PharmacologyCards
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Featured Publications
The dynamic disulphide relay of quiescin sulphydryl oxidase
Alon A, Grossman I, Gat Y, Kodali V, DiMaio F, Mehlman T, Haran G, Baker D, Thorpe C, Fass D. The dynamic disulphide relay of quiescin sulphydryl oxidase. Nature 2012, 488: 414-418. PMID: 22801504, PMCID: PMC3521037, DOI: 10.1038/nature11267.Commentaries, Editorials and LettersIdentification of the gene that codes for the σ2 receptor
Alon A, Schmidt H, Wood M, Sahn J, Martin S, Kruse A. Identification of the gene that codes for the σ2 receptor. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 7160-7165. PMID: 28559337, PMCID: PMC5502638, DOI: 10.1073/pnas.1705154114.Peer-Reviewed Original ResearchAlzheimer DiseaseAnimalsAspartic AcidCarrier ProteinsCattleCholesterolEndoplasmic ReticulumGene Expression RegulationHumansInsectaIntracellular Signaling Peptides and ProteinsLigandsLiverMCF-7 CellsMembrane GlycoproteinsMembrane ProteinsNiemann-Pick C1 ProteinPC12 CellsProtein BindingRatsReceptors, sigmaRecombinant ProteinsRNA, Small InterferingSchizophreniaStructures of the σ2 receptor enable docking for bioactive ligand discovery
Alon A, Lyu J, Braz J, Tummino T, Craik V, O’Meara M, Webb C, Radchenko D, Moroz Y, Huang X, Liu Y, Roth B, Irwin J, Basbaum A, Shoichet B, Kruse A. Structures of the σ2 receptor enable docking for bioactive ligand discovery. Nature 2021, 600: 759-764. PMID: 34880501, PMCID: PMC8867396, DOI: 10.1038/s41586-021-04175-x.Peer-Reviewed Original Research
2024
Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application
Schiffelers L, Tesfamariam Y, Jenster L, Diehl S, Binder S, Normann S, Mayr J, Pritzl S, Hagelauer E, Kopp A, Alon A, Geyer M, Ploegh H, Schmidt F. Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application. Nature Communications 2024, 15: 8266. PMID: 39327452, PMCID: PMC11427689, DOI: 10.1038/s41467-024-52110-1.Peer-Reviewed Original ResearchAlphaFold2 structures guide prospective ligand discovery
Lyu J, Kapolka N, Gumpper R, Alon A, Wang L, Jain M, Barros-Álvarez X, Sakamoto K, Kim Y, DiBerto J, Kim K, Glenn I, Tummino T, Huang S, Irwin J, Tarkhanova O, Moroz Y, Skiniotis G, Kruse A, Shoichet B, Roth B. AlphaFold2 structures guide prospective ligand discovery. Science 2024, 384: eadn6354-eadn6354. PMID: 38753765, PMCID: PMC11253030, DOI: 10.1126/science.adn6354.Peer-Reviewed Original Research
2022
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination
Gao Y, Barajas-Ornelas R, Amon J, Ramírez-Guadiana F, Alon A, Brock K, Marks D, Kruse A, Rudner D. The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination. Genes & Development 2022, 36: 634-646. PMID: 35654455, PMCID: PMC9186386, DOI: 10.1101/gad.349488.122.Peer-Reviewed Original Research
2021
The Spliced Leader RNA Silencing (SLS) Pathway in Trypanosoma brucei Is Induced by Perturbations of Endoplasmic Reticulum, Golgi Complex, or Mitochondrial Protein Factors: Functional Analysis of SLS-Inducing Kinase PK3
Okalang U, Bar-Ner B, Rajan K, Friedman N, Aryal S, Egarmina K, Hope R, Khazanov N, Senderowitz H, Alon A, Fass D, Michaeli S. The Spliced Leader RNA Silencing (SLS) Pathway in Trypanosoma brucei Is Induced by Perturbations of Endoplasmic Reticulum, Golgi Complex, or Mitochondrial Protein Factors: Functional Analysis of SLS-Inducing Kinase PK3. MBio 2021, 12: e02602-21. PMID: 34844425, PMCID: PMC8630539, DOI: 10.1128/mbio.02602-21.Peer-Reviewed Original ResearchDormant spores sense amino acids through the B subunits of their germination receptors
Artzi L, Alon A, Brock K, Green A, Tam A, Ramírez-Guadiana F, Marks D, Kruse A, Rudner D. Dormant spores sense amino acids through the B subunits of their germination receptors. Nature Communications 2021, 12: 6842. PMID: 34824238, PMCID: PMC8617281, DOI: 10.1038/s41467-021-27235-2.Peer-Reviewed Original ResearchDrug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2
Tummino T, Rezelj V, Fischer B, Fischer A, O'Meara M, Monel B, Vallet T, White K, Zhang Z, Alon A, Schadt H, O'Donnell H, Lyu J, Rosales R, McGovern B, Rathnasinghe R, Jangra S, Schotsaert M, Galarneau J, Krogan N, Urban L, Shokat K, Kruse A, García-Sastre A, Schwartz O, Moretti F, Vignuzzi M, Pognan F, Shoichet B. Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2. Science 2021, 373: 541-547. PMID: 34326236, PMCID: PMC8501941, DOI: 10.1126/science.abi4708.Peer-Reviewed Original ResearchCOVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms
Malone R, Tisdall P, Fremont-Smith P, Liu Y, Huang X, White K, Miorin L, Moreno E, Alon A, Delaforge E, Hennecker C, Wang G, Pottel J, Blair R, Roy C, Smith N, Hall J, Tomera K, Shapiro G, Mittermaier A, Kruse A, García-Sastre A, Roth B, Glasspool-Malone J, Ricke D. COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms. Frontiers In Pharmacology 2021, 12: 633680. PMID: 33833683, PMCID: PMC8021898, DOI: 10.3389/fphar.2021.633680.Peer-Reviewed Original Research
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