Patrick Gallagher, MD, BS
Professor Emeritus of PediatricsDownloadHi-Res Photo
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Additional Titles
Director, Yale Center for Blood Disorders
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About
Titles
Professor Emeritus of Pediatrics
Director, Yale Center for Blood Disorders
Appointments
Neonatal-Perinatal Medicine
EmeritusPrimary
Other Departments & Organizations
- Gallagher Lab
- Neonatal Transport Program
- Neonatal-Perinatal Medicine
- Newborn Special Care Unit
- Pathology and Molecular Medicine
- Pathology Research
- Pediatrics
- Rheumatic Diseases Research Core
- Yale Stem Cell Center
- Yale Ventures
- YCCEH
Education & Training
- Fellow - Molecular Hematology
- Yale University School of Medicine (1994)
- Fellow - Neonatal-Perinatal Medicine
- Yale University School of Medicine (1992)
- Chief Resident
- Children's Hospital Medical Center, University of Cincinnati (1989)
- Intern & Resident
- Children's Hospital Medical Center, University of Cincinnati (1988)
- MD
- Northeastern Ohio University (1985)
- BS
- Ohio State University (1976)
Research
Overview
Dr. Gallagher has trained numerous undergraduate, graduate and medical students, MD and PhD postdoctoral fellows, and sabbatical faculty. Laboratory graduates hold positions throughout the world and trainees have
received awards and honors from local, regional, and national organizations. After serving as the PI on the Yale Neonatal/Perinatal Medicine T32 training grant for many years, he now participates in training grants in Genetics, Medicine, and Laboratory Medicine. He serves on the Department of Pediatrics Scholarship Oversight Committee (SOC). He has served on numerous individual SOCs as member or chair, as well as various medical and graduate school mentoring committees, PhD thesis committees, etc.
Medical Research Interests
Anemia, Sickle Cell; Diseases; Elliptocytosis, Hereditary; Erythropoiesis; Genetics; Genomics; Health Care; Hemoglobinopathies; Hydrops Fetalis; Information Science; Neonatology; Pathology; Pediatrics; Polycythemia; Pyruvate Kinase; Spherocytosis, Hereditary
ORCID
0000-0002-5424-0224
Research at a Glance
Yale Co-Authors
Frequent collaborators of Patrick Gallagher's published research.
Publications Timeline
A big-picture view of Patrick Gallagher's research output by year.
Research Interests
Research topics Patrick Gallagher is interested in exploring.
Vincent Schulz, PhD
Louise-Marie Dembry, MD, FACP, MS, MBA, FIDSA, BS
Diane Krause, MD, PhD
Matthew Bizzarro, MD
Joseph Craft, MD
Jesse Rinehart, PhD
353Publications
12,163Citations
Spherocytosis, Hereditary
Erythropoiesis
Elliptocytosis, Hereditary
Hydrops Fetalis
Anemia, Sickle Cell
Pyruvate Kinase
Publications
2025
Welcome to Blood Red Cells & Iron
Gallagher P, Silvestri L. Welcome to Blood Red Cells & Iron. Blood Red Cells & Iron 2025, 1: 100008. DOI: 10.1016/j.brci.2025.100008.Peer-Reviewed Original Research
2024
A pinch of salt to enhance preemie growth?
Steflik H, Pearlman S, Gallagher P, Lakshminrusimha S. A pinch of salt to enhance preemie growth? Journal Of Perinatology 2024, 45: 295-297. PMID: 39567649, DOI: 10.1038/s41372-024-02174-0.Peer-Reviewed Original ResearchCitationsMouse Models of Hereditary Xerocytosis-Associated PIEZO1 Mutations Reveal Genotype-Phenotype Differences in Hematological Defects and Iron Loading
Finberg K, Peres Diaz L, Shan P, Chua E, Lalwani K, Gallagher P. Mouse Models of Hereditary Xerocytosis-Associated PIEZO1 Mutations Reveal Genotype-Phenotype Differences in Hematological Defects and Iron Loading. Blood 2024, 144: 3851-3851. DOI: 10.1182/blood-2024-203740.Peer-Reviewed Original ResearchConceptsRed cell distribution widthHereditary xerocytosisSpleen weight/body weight ratioRed blood cell countMean corpuscular volumeCompared to wild-typeHematological defectsMouse modelHeart weight/body weight ratioWild-typeIron loadingComplete blood count analysisRed blood cell turnoverSerum transferrin saturationC57BL/6 genetic backgroundSerum hepcidin levelsLiver iron loadingYoung adult miceGenotype-phenotype differencesCell distribution widthMean corpuscular hemoglobinGain-of-function mutationsBlood count analysisNon-heme iron concentrationsRed cell indicesHEXIM1 Regulates Early Erythropoiesis and Participates in Multiple Complexes in Erythroid Cells
Rahman N, Abid D, Lv X, Murphy K, Getman M, McGrath K, Gallagher P, Narla M, Blanc L, Palis J, Mello S, Steiner L. HEXIM1 Regulates Early Erythropoiesis and Participates in Multiple Complexes in Erythroid Cells. Blood 2024, 144: 536. DOI: 10.1182/blood-2024-209259.Peer-Reviewed Original ResearchConceptsRNA polymerase IIErythroid gene expressionGene expressionTerminal erythroid maturationEarly erythropoiesisErythroid cellsErythroid maturationRegulation of gene expressionProgenitor cellsImpaired erythroid differentiationRNAPII pausingGenomic contextPolymerase IIRepress transcriptionSteady-state erythropoiesisErythroid progenitor cellsCD34+ HSPCsRegulatory domainBinding partnersErythropoiesis in vivoBlood cell countColony-forming cellsLow red blood cell countSubnuclear bodiesErythroid progenitor differentiationHematopoietic Stem Cells Supporting Fetal Erythropoiesis Are Differentially Regulated By Small and Large Ribosomal Subunits
Tang Y, Ling T, Mehmood R, Khan M, Papoin J, Palis J, Steiner L, Durand S, Zon L, Bhoopalan S, Weiss M, Lipton J, Taylor N, Gallagher P, Narla M, Crispino J, Blanc L. Hematopoietic Stem Cells Supporting Fetal Erythropoiesis Are Differentially Regulated By Small and Large Ribosomal Subunits. Blood 2024, 144: 195. DOI: 10.1182/blood-2024-210699.Peer-Reviewed Original ResearchConceptsDiamond-Blackfan anemiaHaplo-insufficient miceFetal hematopoiesisHematopoietic stemBFU-EProgenitor cellsCongenital bone marrow failure syndromeMouse modelClinically relevant mouse modelBone marrow failure syndromesProtein haploinsufficiencyBasophilic erythroblastsMarrow failure syndromesBone marrow failureFetal liver cellsRelevant mouse modelConsistent with clinical findingsPost-natal dayConditional mouse modelErythroid lineage cellsRibosomal protein haploinsufficiencyAssociated with mutationsExpression of RUNX1BFU-E stageRUNX1 alleleA Short Isoform of Tensin1 Is a Novel Regulator of F-Actin Assembly in Human Erythroblasts That Promotes Enucleation
Fowler V, Ghosh A, Coffin M, Diaz D, Schulz V, Gallagher P. A Short Isoform of Tensin1 Is a Novel Regulator of F-Actin Assembly in Human Erythroblasts That Promotes Enucleation. Blood 2024, 144: 535-535. DOI: 10.1182/blood-2024-210773.Peer-Reviewed Original ResearchConceptsRegulation of F-actin assemblyF-actin assemblyF-actinATAC-peaksH3K27 acetylationN-terminal actin-binding domainErythroid differentiationEnucleated cellsActin-binding domainActin-nucleating factorsF-actin cablesActin-binding proteinsTerminal differentiationActin filament polymerizationC-terminal SH2Translation start siteAssemble F-actinFocal adhesion formationDetect F-actinIncreased chromatin accessibilityErythroid terminal differentiationMolecular regulatory mechanismsSpectrin membrane skeletonMRNA translational start siteReduced F-actinDexamethasone Targets E2F4 to Induce Erythroid Progenitor Renewal
Papoin J, Schulz V, Khan F, Barnes B, Lipton J, Steiner L, Narla M, Gallagher P, Blanc L. Dexamethasone Targets E2F4 to Induce Erythroid Progenitor Renewal. Blood 2024, 144: 1076. DOI: 10.1182/blood-2024-211687.Peer-Reviewed Original ResearchConceptsDiamond-Blackfan anemiaCD34+ cellsErythroid progenitorsSteroid responsivenessExpression of E2F4Peripheral bloodBone marrowE2F4 expressionDex treatmentCultured CD34+ cellsInherited bone marrow failure syndromeMechanisms of steroid responseSide effectsBone marrow failure syndromesDiamond-Blackfan anemia patientsBone marrow erythroid progenitorsIncreased expressionMechanisms of corticosteroid actionAssociated with side effectsIncreased risk of infectionMarrow failure syndromesResponse to steroidsGene promoterSerum-free culture systemMarrow erythroid progenitorsPhenotypic and genotypic evaluation of bleeding diagnostic dilemmas: Two case studies
Gu S, Butt A, Schulz V, Rinder H, Lee A, Gallagher P, Hwa J, Bona R. Phenotypic and genotypic evaluation of bleeding diagnostic dilemmas: Two case studies. Blood Cells Molecules And Diseases 2024, 110: 102893. PMID: 39260211, DOI: 10.1016/j.bcmd.2024.102893.Peer-Reviewed Original ResearchCitationsConceptsInherited platelet disordersClinically significant bleedingCases of patientsHeterogeneous group of conditionsGroup of conditionsSignificant bleedingDiagnostic yieldDiagnostic dilemmaPlatelet disordersBleeding disordersEvaluating patientsPatient cohortMolecular pathogenesisMass cytometryHeterogeneous groupPatientsMultimodal approachBleedingImprove patient careDiagnosisDisordersPatient careGenetic sequencesLaboratory testing approachPotential utilityAbstract 1147: Crosstalk Between Alk5 And Mtorc1 Signaling Promotes VSMC Differentiation And The Therapeutic Effect Of Rapamycin
Chakraborty R, Chatterjee P, Dave J, Obrien B, Joshi D, Schulz V, Greif D, Hwa J, Gallagher P, Martin K. Abstract 1147: Crosstalk Between Alk5 And Mtorc1 Signaling Promotes VSMC Differentiation And The Therapeutic Effect Of Rapamycin. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: a1147-a1147. DOI: 10.1161/atvb.44.suppl_1.1147.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsTherapeutic effect of rapamycinEffects of rapamycinVSMC differentiationContractile genesConsistent with in vitro findingsRapamycin treatmentCarotid artery injuryHuman coronary artery SMCsVascular smooth muscle cell differentiationIntimal hyperplasiaSmooth muscle cellsCoronary artery SMCsMTORC1 inhibitor rapamycinPhosphorylation of Smad2/3Inhibition of ALK5Smad-binding elementSmad transcription factorsALK5 activityArterial injuryArtery SMCsKnockout miceInhibition of mTORC1Vascular smooth muscle cell plasticityMuscle cellsSurvey research in perinatal medicine
Conroy S, Gallagher P. Survey research in perinatal medicine. Journal Of Perinatology 2024, 44: 771-772. PMID: 38538912, DOI: 10.1038/s41372-024-01940-4.Peer-Reviewed Original Research
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