2023
The Combination Therapy of Glucocorticoids, Tacrolimus, and Mycophenolate Mofetil in Primary Membranous Nephropathy Coexisting with Type 2 Diabetes Mellitus: A Retrospective Study
Wang Y, Cui C, Tian X, Wang L, Ma X, Ge H, Zhang L, Xue X, Chen Z, Huo Y, Wang H, Fu R, Jia L. The Combination Therapy of Glucocorticoids, Tacrolimus, and Mycophenolate Mofetil in Primary Membranous Nephropathy Coexisting with Type 2 Diabetes Mellitus: A Retrospective Study. Integrative Medicine In Nephrology And Andrology 2023, 10: e00010. DOI: 10.1097/imna-d-22-00010.Peer-Reviewed Original ResearchPrimary membranous nephropathyMycophenolate mofetilCTX groupMembranous nephropathyType 2 diabetes mellitusCombination of glucocorticoidsSerum albumin levelUrinary protein excretionData of patientsLong-term efficacyWorse glycemic controlCTX regimenProteinuria reductionCyclophosphamide regimenAlbumin levelsDiabetes mellitusGlycemic controlImmunosuppressive agentsProtein excretionRetrospective studyCombination therapyBlood glucoseType 2Disease severityGlucocorticoids
2017
Loss of the podocyte glucocorticoid receptor exacerbates proteinuria after injury
Zhou H, Tian X, Tufro A, Moeckel G, Ishibe S, Goodwin J. Loss of the podocyte glucocorticoid receptor exacerbates proteinuria after injury. Scientific Reports 2017, 7: 9833. PMID: 28852159, PMCID: PMC5575043, DOI: 10.1038/s41598-017-10490-z.Peer-Reviewed Original ResearchConceptsKnockout miceGlucocorticoid receptorNephrotic syndromeSimilar renal functionMainstay of therapyReceptor knockout miceTreatment of proteinuriaFoot process effacementMechanism of actionImmunomodulatory therapyRenal functionGlomerular injuryProtein excretionKO miceCommon disorderNephrotoxic serumPodocyte injuryPodocyte-specific deletionMouse modelSlit diaphragm proteinsWild-type podocytesProcess effacementProteinuriaUnstimulated conditionsKnockout animals