Mouse Metabolic Phenotyping Center

The Yale Mouse Metabolic Phenotyping Center – Live (Yale MMPC-Live) provides extramural investigators access to the unique metabolic phenotyping services offered by the Yale MMPC and empowers them to harness the power of mouse genetics to its fullest potential to metabolically phenotype their mouse models of obesity and diabetes. It includes the Animal Core, Phenotyping Core along with its sub-cores: Metabolic Imaging, Islet Cell Biology, Thermometabolism, and Functional Cardiac Metabolism. The goal is to offer a resource to perform metabolic phenotyping of diabetic and insulin-resistant mice in collaboration with investigators around the world.

This Center is part of a national consortium from the National Institutes of Health. Visit their website for more information on the National Mouse Metabolic Phenotyping Centers.

Leadership

Gerald I Shulman, MD, PhD, MACP, MACE, FRCP
Director, Yale MMPC; Director, Yale MMPC Metabolic Phenotyping Core
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James Macy Jr, DVM
Associate Director, Yale MMPC; Director, Yale MMPC Animal Core
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Goals

Broaden the scope of techniques available to investigators
Standardize key methodologies
Expedite the completion of research
Compile a database for mouse models of diabetes

Structure of the MMPC

Cores

Yale MMPC-Live consists of three highly interactive Cores that have an established 20+ year track record of working together in close harmony:

The Yale MMPC Administrative Core oversees the operation of the Yale MMPC, facilitates research with the other MMPC Centers and the MMPC Coordinating Unit to standardize key methodologies, and coordinates the efficient workflow through the Yale MMPC cores and access to the Yale MMPC Animal Core and the Yale MMPC Phenotyping Core.
The Yale MMPC Animal Core provides a centralized facility for coordinating, receiving, screening, and monitoring mice from outside investigators.
The Yale MMPC Phenotyping Core empowers Yale MMPC clients with access to unique metabolic phenotyping services that provide them with the means to characterize the metabolic changes in their particular mouse models of complex metabolic disease using established state-of-the-art methodology.

Yale MMPC-Live Vibrant Program

The Yale MMPC-Live Vibrant program offers funded (free to the applicant) grant reviews by tenured faculty to PIs applying to R-level grant opportunities in the area of mouse metabolism. This opportunity is open to PIs who are New Investigators per the NIH definition (those who have not yet competed successfully for an R01-level NIH grant) and are EITHER part of a group historically marginalized in biomedical research, or faculty at a primarily minority-serving institution. Grant reviews will be offered on a rolling basis, but the deadline to indicate interest for October R01s is September 1, 2024.

If you are interested in this opportunity, please fill out this brief form. For any questions, please email Dr. Rachel Perry.

Program Leadership

Rachel Jamison Perry, PhD
Director, Yale MMPC-Live Vibrant Program
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Local Steering Committee

A local steering committee will be created to assist the Yale MMPC Director, Associate Director, and Core/Sub-Core Directors in making decisions regarding test offerings and development, budget and prioritization decisions, and help adjudicate client disputes. At least one member of the local steering committee will be a senior researcher at the institution who is not directly involved in the Yale MMPC.