Dysregulation of human Toll-like receptor function in aging
Shaw AC, Panda A, Joshi SR, Qian F, Allore HG, Montgomery RR. Dysregulation of human Toll-like receptor function in aging. Ageing Research Reviews 2010, 10: 346-353. PMID: 21074638, PMCID: PMC3633557, DOI: 10.1016/j.arr.2010.10.007.Peer-Reviewed Original ResearchConceptsToll-like receptorsTLR functionImmune systemToll-like receptor functionPattern recognition receptor familyAge-associated dysregulationInnate immune systemGeriatric patientsTLR activationAnimal modelsContext of agingReceptor functionHuman cohortsInfectious diseasesReceptor familyInappropriate persistenceDysregulationRecent studiesOverarching themesAdaptive responseMorbidityImmunosenescencePatientsCohortInnateAging of the innate immune system
Shaw AC, Joshi S, Greenwood H, Panda A, Lord JM. Aging of the innate immune system. Current Opinion In Immunology 2010, 22: 507-513. PMID: 20667703, PMCID: PMC4034446, DOI: 10.1016/j.coi.2010.05.003.Peer-Reviewed Original ResearchConceptsInnate immune systemImmune systemPro-inflammatory environmentInnate immune activationToll-like receptorsMonocytes/macrophagesAge-associated defectsNKT cellsDendritic cellsImmune activationElderly individualsTissue damageNetwork of cellsCell typesSignal transduction pathwaysCellsActivationEarly interactionsTransduction pathwaysImmunosenescenceNeutrophilsInfectionMacrophagesNKReceptors