2019
Toll-Like Receptors 2 and 4 Modulate Pulmonary Inflammation and Host Factors Mediated by Outer Membrane Vesicles Derived from Acinetobacter baumannii
Marion CR, Lee J, Sharma L, Park KS, Lee C, Liu W, Liu P, Feng J, Gho YS, Dela Cruz CS. Toll-Like Receptors 2 and 4 Modulate Pulmonary Inflammation and Host Factors Mediated by Outer Membrane Vesicles Derived from Acinetobacter baumannii. Infection And Immunity 2019, 87: 10.1128/iai.00243-19. PMID: 31262980, PMCID: PMC6704609, DOI: 10.1128/iai.00243-19.Peer-Reviewed Original ResearchConceptsToll-like receptorsPulmonary inflammationOuter membrane vesiclesToll-like receptor 2TLR4-deficient miceVentilator-associated pneumoniaWild-type miceSystemic inflammationNeutrophil recruitmentIntranasal introductionProinflammatory responseReceptor 2Acinetobacter baumanniiInflammationMouse lungHigh mortalityHost factorsWeight lossMicePneumoniaGram-negative bacteriumMembrane vesiclesGram-negative bacteriaTLR2Chemokines
2018
BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation
Britto CJ, Niu N, Khanal S, Huleihel L, Herazo-Maya J, Thompson A, Sauler M, Slade MD, Sharma L, Dela Cruz CS, Kaminski N, Cohn LE. BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2018, 316: l321-l333. PMID: 30461288, PMCID: PMC6397348, DOI: 10.1152/ajplung.00056.2018.Peer-Reviewed Original ResearchConceptsLung inflammationAcute inflammationC motif chemokine ligand 10Lung neutrophil recruitmentRegulation of CXCL10Acute lung inflammationBronchoalveolar lavage concentrationsChemokine ligand 10Innate immune responseIFN regulatory factorIntranasal LPSLavage concentrationsLung recruitmentNeutrophil recruitmentWT miceImmune effectsLung diseasePMN recruitmentInflammatory responseLPS treatmentLung tissueInflammatory signalsImmune responseImmunomodulatory propertiesInflammation