2023
Pathophysiology and clinical management of coronavirus disease (COVID-19): a mini-review
Zhu Y, Sharma L, Chang D. Pathophysiology and clinical management of coronavirus disease (COVID-19): a mini-review. Frontiers In Immunology 2023, 14: 1116131. PMID: 37646038, PMCID: PMC10461092, DOI: 10.3389/fimmu.2023.1116131.Peer-Reviewed Original ResearchConceptsClinical managementAppropriate host immune responseSevere acute pneumoniaMultiple organ failureCOVID-19 pathogenesisSecondary bacterial infectionLower respiratory systemSpecific pathogenic mechanismsHost immune responseLife-threatening consequencesCOVID-19SARS-CoV-2Spread of infectionOrgan failureAcute pneumoniaExcessive inflammationInfected subjectsSystemic diseaseProtease TMPRSS2Mild infectionImmune responseHealthcare threatPathogenic mechanismsTherapeutic paradigmBacterial infections
2020
Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19)
Guo L, Ren L, Yang S, Xiao M, Chang D, Yang F, Dela Cruz CS, Wang Y, Wu C, Xiao Y, Zhang L, Han L, Dang S, Xu Y, Yang Q, Xu S, Zhu H, Xu Y, Jin Q, Sharma L, Wang L, Wang J. Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19). Clinical Infectious Diseases 2020, 71: 778-785. PMID: 32198501, PMCID: PMC7184472, DOI: 10.1093/cid/ciaa310.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Humoral responseSymptom onsetIgM ELISAProbable casesEarly humoral responseHost humoral responseMajor healthcare threatCoronavirus disease 2019IgA antibody detectionCOVID-19Viral nucleic acidsQuantitative polymerase chain reactionNovel coronavirus diseaseFalse-negative resultsMedian durationAntibody testingIgG responsesIgM antibodiesInfected patientsPolymerase chain reactionPositive rateDisease 2019Healthcare threatSubclinical cases