Julius Chapiro, MD, PhD
Associate Professor of Radiology and Biomedical ImagingCards
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileAdditional Titles
Associate Professor , Digestive Diseases
Associate Professor , Biomedical Engineering
Principal Investigator, Yale Interventional Oncology Laboratory , Radiology & Biomedical Imaging
Director, Center for Minimally Invasive Therapies, Radiology & Biomedical Imaging
Associate Director, Clinical and Translational Core, Liver Center
Contact Info
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileAdditional Titles
Associate Professor , Digestive Diseases
Associate Professor , Biomedical Engineering
Principal Investigator, Yale Interventional Oncology Laboratory , Radiology & Biomedical Imaging
Director, Center for Minimally Invasive Therapies, Radiology & Biomedical Imaging
Associate Director, Clinical and Translational Core, Liver Center
Contact Info
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileAdditional Titles
Associate Professor , Digestive Diseases
Associate Professor , Biomedical Engineering
Principal Investigator, Yale Interventional Oncology Laboratory , Radiology & Biomedical Imaging
Director, Center for Minimally Invasive Therapies, Radiology & Biomedical Imaging
Associate Director, Clinical and Translational Core, Liver Center
Contact Info
About
Copy Link
Titles
Associate Professor of Radiology and Biomedical Imaging
Associate Professor , Digestive Diseases; Associate Professor , Biomedical Engineering; Principal Investigator, Yale Interventional Oncology Laboratory , Radiology & Biomedical Imaging; Director, Center for Minimally Invasive Therapies, Radiology & Biomedical Imaging; Associate Director, Clinical and Translational Core, Liver Center
Biography
Dr. Chapiro is a board-certified Diagnostic and Interventional Radiologist and an Associate Professor of Radiology, Digestive Diseases (Hepatology) and of Biomedical Engineering. He is the Principal Investigator of the Yale Interventional Oncology Research Lab and Director of the Center for Minimally Invasive Therapies. After graduating from the University of Leipzig and upon completion of his research thesis at the Justus-Liebig University in Giessen with summa cum laude, he served as a postdoctoral research fellow in interventional oncology at The Johns Hopkins Hospital and then as radiology resident at the Department of Radiology, Charité University Hospital in Berlin. He joined the Department of Radiology and Biomedical Imaging in 2016 as a research scientist and interventional radiology resident from Berlin, Germany.
Dr. Chapiro’s research focuses on developing new quantitative imaging biomarkers for the diagnosis, characterization, and therapeutic management of liver cancer. His translational research portfolio includes the development of novel embolic agents as well as the application of artificial intelligence solutions for the management of liver cancer. His basic research interest mainly focuses on developing new tools to characterize the tumor microenvironment and the immune system in the setting of loco-regional, image-guided therapies of liver cancer.
Creating innovative and clinically applicable imaging solutions for liver cancer with advanced molecular imaging, image post-processing and machine learning approaches and translating them to clinical practice has been his central mission for the past decade. He authored and co-authored >170 original research articles, reviews and book chapters and gave more than 150 talks and invited lectures at national and international forums within the last seven years including in Europe, China, South Korea and the Middle East. His research has also resulted in several patents, 510(k)-approved medical products and significant grant support from federal, foundational and industry sources. He is an active research mentor to more than 70 undergraduate, medical and graduate students as well as peers both at Yale and other national and international institutions. Being an active contributor, journal-, abstract- and grant reviewer in several professional societies (RSNA, SIR, CIRSE and SIO), he is also committed to education and the mission of disseminating research data and scientific knowledge. Dr. Chapiro is an Editorial Board member of the Journal of Hepatology (EASL), Radiology and Radiology: AI (RSNA), Journal of Vascular and Interventional Radiology (SIR) and Cardiovascular and Interventional Radiology: Oncology (CIRSE). He is a member of the American College of Radiology Liver Imaging Reporting and Data System (LI-RADS) Steering Committee, he additionally chairs the Grant Committee of the Society of Interventional Oncology and chaired the Annual Meeting Program Planning Committee for the Subspecialty of Interventional Radiology at the Annual Radiological Society of North America meeting 2021-2023. He is the co-initiator of the "Rising Star" Student Exchange Program in collaboration with the Charité University Hospital in Berlin and directs the Center for Minimally Invasive Therapies. Dr. Chapiro is the Associate Director of the Clinical and Translational Core of the Yale Liver Center.
Appointments
Radiology & Biomedical Imaging
Associate Professor on TermPrimaryBiomedical Engineering
Associate Professor on TermSecondaryDigestive Diseases
Assistant ProfessorSecondary
Other Departments & Organizations
- Bioimaging Sciences
- Biomedical Engineering
- Clinical Radiology
- Digestive Diseases
- Internal Medicine
- Interventional Radiology
- Liver Cancer Program
- Radiology & Biomedical Imaging
- Vascular & Interventional Radiology
- Yale Biomedical Imaging Institute
- Yale Interventional Oncology Research Lab
- Yale Medicine
- Yale New Haven Health System
Education & Training
- Interventional Radiology Resident
- Yale New Haven Hospital
- Diagnostic Radiology Resident
- Charité Universitätsmedizin Berlin
- PhD
- Justus Liebig University
- Research Fellow in Interventional Oncology
- The Johns Hopkins Hospital
- MD
- University of Leipzig
Research
Copy Link
Overview
Medical Research Interests
ORCID
0000-0002-1984-2246
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
MingDe Lin, PhD
Todd Schlachter, MD
James Duncan, PhD
David C. Madoff, MD
Fabian Max Laage Gaupp, MD
Annabella Shewarega, MD
Carcinoma, Hepatocellular
Magnetic Resonance Imaging
Liver
Neoplasm Staging
Image Processing, Computer-Assisted
Artificial Intelligence
Publications
2026
The Quality of Radiology Artificial Intelligence Research: Counterpoint-The Long Road From Discovery to Deployment.
Abosabie S, Chapiro J. The Quality of Radiology Artificial Intelligence Research: Counterpoint-The Long Road From Discovery to Deployment. American Journal Of Roentgenology 2026 PMID: 42308089, DOI: 10.2214/ajr.26.35398.Peer-Reviewed Original ResearchAltmetricConceptsCT Radiomics to Predict Regenerative Biomarker Expression after Liver Venous Embolization: Proof-of-Concept in a Porcine Model
Nguyenová J, Yang J, Zhang X, Shewarega A, Tefera J, Kuhn T, Gebauer B, Savic L, Chapiro J, Madoff D. CT Radiomics to Predict Regenerative Biomarker Expression after Liver Venous Embolization: Proof-of-Concept in a Porcine Model. Journal Of Vascular And Interventional Radiology 2026, 108895. PMID: 42269821, DOI: 10.1016/j.jvir.2026.108895.Peer-Reviewed Original ResearchConceptsPortal vein embolizationVascular endothelial growth factorCT radiomicsKi-67Venous embolizationBiomarker expressionVein embolizationAngiopoietin-1Expression of vascular endothelial growth factorSham controlsHepatic vein embolizationCaspase 3N-butyl cyanoacrylateEndothelial growth factorModerate discriminative performanceFLR hypertrophyLiver remnantEpithelial integrityEmbolizationRegenerative responseEmbolized lobeGrowth factorRadiomicsLiver conditionsLogistic regressionEstablishing selection criteria for male New Zealand white rabbits in interventional radiology research using organ volumes and vessel diameters
Saclier S, He Y, Klockner J, Noack L, Ramtke J, Chapiro J, Ruppel R, Hesse F, Abosabie S, Unger J, Schmidt R, Gebauer B, Savic L. Establishing selection criteria for male New Zealand white rabbits in interventional radiology research using organ volumes and vessel diameters. European Radiology Experimental 2026, 10: 57. PMID: 42047748, PMCID: PMC13125672, DOI: 10.1186/s41747-026-00708-z.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsInterventional radiology researchOrgan volumeAnatomic suitabilityBody weightAttribution of adverse eventsVX2 rabbit modelNZW rabbitsMagnetic resonance imaging scansVessel diameterRight renal arteryMale New Zealand white rabbitsImage-guided proceduresNew Zealand white rabbitsAnatomical reference dataZealand white rabbitsImaging-based measurementsLiver volumetryTechnical successImage-guided interventionsAdverse eventsMethodsComputed tomographyProcedural riskCeliac trunkCross-sectional imagingRenal arteryDeep learning-based generation of synthetic multiphasic MRI in hepatocellular carcinoma and cirrhosis
Abosabie S, Abosabie S, Dai W, Yang J, Gross M, Weinreb J, Revzin M, Parmar G, You C, Lin M, Gaddum O, Gebauer B, Savic L, Madoff D, Duncan J, Chapiro J. Deep learning-based generation of synthetic multiphasic MRI in hepatocellular carcinoma and cirrhosis. JHEP Reports 2026, 8: 101813. PMID: 41887530, PMCID: PMC13251683, DOI: 10.1016/j.jhepr.2026.101813.Peer-Reviewed Original ResearchCitationsConceptsCycle-consistent generative adversarial networkGenerative adversarial networkVisual Turing testGround-truth imagesAdversarial networkSingle-center datasetDeep learningHepatocellular carcinomaMRI examsSymmetric mean absolute percent errorTuring testPerformance metricsGround truthDisease diagnosingCirrhosis patientsQuantitative metricsOverlap metricsImage qualityMulti-reader studyPrecontrast sequencesLiver Imaging ReportingMetricsContrast media useContrast-enhanced MRIEvaluate similaritiesNeoadjuvant PD-1 Inhibition prior to Partial Cryoablation of Murine Hepatocellular Carcinoma Modulates the Tumor Microenvironment toward Favorable Immunological Profiles
Kao T, Santana J, Meister E, Shewarega A, Israel J, Peschke L, Tefera J, Matuschewski N, Sobirey R, Zhang X, Gebauer B, Madoff D, Savic L, Chapiro J. Neoadjuvant PD-1 Inhibition prior to Partial Cryoablation of Murine Hepatocellular Carcinoma Modulates the Tumor Microenvironment toward Favorable Immunological Profiles. Journal Of Vascular And Interventional Radiology 2026, 37: 108585. PMID: 41690670, PMCID: PMC13052828, DOI: 10.1016/j.jvir.2026.108585.Peer-Reviewed Original ResearchAltmetricConceptsAnti-PD-1Immune checkpoint inhibitionMurine hepatocellular carcinomaHepatocellular carcinomaCheckpoint inhibitionPD-1Residual tumorTumor microenvironmentT cellsTIB-75Infiltration of CD3+ T cellsHistopathological analysisInfiltration of CD3+Mouse modelAdvanced-stage hepatocellular carcinomaMouse model of hepatocellular carcinomaCD8+ T cellsPercentage of positively stained cellsCD3+ T cellsPresence of T-cell subsetsModel of hepatocellular carcinomaLesions of hepatocellular carcinomaImmunosuppressive tumor microenvironmentPD-1 expressionT cell subsetsDeep learning based volumetric analysis of infrarenal abdominal aortic aneurysms characterized on CTA
Weiss D, Hager T, Lin M, Sritharan D, Bousabarah K, Renninghoff D, Holler W, Simmons K, Haubold J, Loh S, Fischer U, Chapiro J, Deuschl C, Aboian M, Aboian E, Aneja S. Deep learning based volumetric analysis of infrarenal abdominal aortic aneurysms characterized on CTA. Npj Digital Medicine 2026, 9: 87. PMID: 41519965, PMCID: PMC12852869, DOI: 10.1038/s41746-025-02262-1.Peer-Reviewed Original ResearchAltmetricConceptsAssessment of abdominal aortic aneurysmsComputed tomography angiographyAbdominal aortic aneurysmVolumetric analysisGround-truth segmentationsAortic aneurysmVolumetric assessmentInfrarenal abdominal aortic aneurysmDeep learningGround truthVolume determinationAortic repairDice similarity coefficientAneurysmThrombus volumeAutomated SegmentationNetworkSecondary aimDetermination of pre-Similarity coefficient
2025
Radiomics beyond the visible—Decoding tumor heterogeneity to guide combination therapy of intermediate-stage HCC
Lotter W, Chapiro J. Radiomics beyond the visible—Decoding tumor heterogeneity to guide combination therapy of intermediate-stage HCC. Hepatology 2025, 10.1097/hep.0000000000001622. PMID: 41247826, PMCID: PMC13277569, DOI: 10.1097/hep.0000000000001622.Peer-Reviewed Original ResearchPublisher Correction: Interventional Radiology Reporting Standards and Checklist for Artificial Intelligence Research Evaluation (iCARE)
Anibal J, Huth H, Boeken T, Daye D, Gichoya J, Muñoz F, Chapiro J, Wood B, Sze D, Hausegger K. Publisher Correction: Interventional Radiology Reporting Standards and Checklist for Artificial Intelligence Research Evaluation (iCARE). CardioVascular And Interventional Radiology 2025, 48: 1546-1546. PMID: 40925982, DOI: 10.1007/s00270-025-04125-4.Peer-Reviewed Original ResearchAltmetricConceptsNoninvasive Tumor Profiling: Quantitative Contrast-Enhanced MRI Markers Predict PD-L1 and CTNNB1 Status in Hepatocellular Carcinoma.
Matuschewski N, Sobirey R, Revzin M, Zeevi T, Gross M, Kasolowsky V, Shewarega A, Meister E, Kao T, Tefera J, Bousabarah K, Batra R, Strazzabosco M, Lin M, Gebauer B, Savic L, Duncan J, Madoff D, Zhang X, Chapiro J. Noninvasive Tumor Profiling: Quantitative Contrast-Enhanced MRI Markers Predict PD-L1 and CTNNB1 Status in Hepatocellular Carcinoma. Radiology 2025, 316: e242750. PMID: 40762840, PMCID: PMC12405729, DOI: 10.1148/radiol.242750.Peer-Reviewed Original ResearchCitationsAltmetricInterventional Radiology Reporting Standards and Checklist for Artificial Intelligence Research Evaluation (iCARE)
Anibal J, Huth H, Boeken T, Daye D, Gichoya J, Muñoz F, Chapiro J, Wood B, Sze D, Hausegger K. Interventional Radiology Reporting Standards and Checklist for Artificial Intelligence Research Evaluation (iCARE). CardioVascular And Interventional Radiology 2025, 48: 1075-1087. PMID: 40560391, DOI: 10.1007/s00270-024-03956-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsArtificial intelligencePrivacy protectionModel deploymentDataset curationPre-trainingAI developmentResearch evaluationBias mitigationTechnological systemsWorkflowPrivacyInterventional radiologyExplainabilityDatasetDeploymentIntelligenceDelivery of careTask-specific trainingRobustnessPeer-reviewed journals
Clinical Care
Copy Link
Overview
Julius Chapiro, MD, is an interventional radiologist who specializes in treating patients with liver cancer. As a physician-scientist, his research focuses on developing new imaging biomarkers to diagnose, characterize, and treat liver cancer.
Dr. Chapiro’s works includes creating advanced molecular imaging methods and incorporating machine-learning approaches.
In addition to his clinical work and research, Dr. Chapiro is an associate editor for the Journal of Hepatology and a member of the American College of Radiology Liver Imaging Reporting and Data System (LI-RADS) Steering Committee. He is also the co-initiator of the Rising Star Student Exchange Program in collaboration with the Charité University Hospital in Berlin and co-directs the Yale Interventional Oncology Research Laboratory.
Dr. Chapiro is an assistant professor at Yale School of Medicine in Radiology, Digestive Diseases, and Biomedical Engineering. He is the associate director of the Clinical Core of the Yale Liver Center.
Clinical Specialties
Board Certifications
Interventional Radiology & Diagnostic Radiology
- Certification Organization
- AB of Radiology
- Original Certification Date
- 2025
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileNews & Links
Copy Link
Media
News
- May 07, 2026Source: Radiological Society of North America News
RSNA Member Spotlight: Julius Chapiro, MD, PhD
- February 04, 2026
Three Honored with Radiological Society’s Educator of the Year Award
- June 30, 2025Source: WTNH News 8 (with Dr. Julius Chapiro)
The future of liver cancer care and therapies
- April 29, 2025
Listen to Dr. Julius Chapiro on the BackTable VI Podcast
Related Links
Get In Touch
Copy Link
Contacts
Events
Yale Only Julius Chapiro, MD, PhD