2021
D Radiotranscriptomic analysis of perivascular adipose tissue quantifies vascular inflammation in covid-19 from routine CT angiograms: Stratification of “new UK variant” Infection and prediction of in-hospital outcomes
Kotanidis C, Xie C, Adlam D, Rodrigues J, Siddique M, Lockstone H, Thomas S, Kotronias R, Oikonomou E, Lumley S, Neubauer S, Newby D, Channon K, Deanfield J, Antoniades C. D Radiotranscriptomic analysis of perivascular adipose tissue quantifies vascular inflammation in covid-19 from routine CT angiograms: Stratification of “new UK variant” Infection and prediction of in-hospital outcomes. Heart 2021, 107: a177-a178. DOI: 10.1136/heartjnl-2021-bcs.238.Peer-Reviewed Original ResearchCT pulmonary angiogramComputed tomography angiographyHigher vascular inflammationVascular inflammationCOVID-19 infectionHospital mortalityPrognostic valueCOVID-19Acute COVID-19 infectionExternal testing cohortAnti-inflammatory treatmentInternal mammary arteryPerivascular adipose tissueCOVID-19 patientsVascular inflammatory responseUK variantSARS-CoV-2Novel imaging biomarkersHospital outcomesMammary arteryPulmonary angiogramArterial inflammationHazard ratioClinical factorsRisk stratification
2017
Detecting human coronary inflammation by imaging perivascular fat
Antonopoulos AS, Sanna F, Sabharwal N, Thomas S, Oikonomou EK, Herdman L, Margaritis M, Shirodaria C, Kampoli AM, Akoumianakis I, Petrou M, Sayeed R, Krasopoulos G, Psarros C, Ciccone P, Brophy CM, Digby J, Kelion A, Uberoi R, Anthony S, Alexopoulos N, Tousoulis D, Achenbach S, Neubauer S, Channon KM, Antoniades C. Detecting human coronary inflammation by imaging perivascular fat. Science Translational Medicine 2017, 9 PMID: 28701474, DOI: 10.1126/scitranslmed.aal2658.Peer-Reviewed Original ResearchConceptsPerivascular adipose tissueFat attenuation indexVascular inflammationSubclinical coronary artery diseaseHuman adipose tissue explantsHuman vesselsLipid accumulationHuman coronary vasculatureAcute coronary syndromeCoronary artery diseaseVulnerable atherosclerotic plaquesIntracellular lipid accumulationHuman coronary arteriesAdipocyte lipid contentAdipose tissue explantsPositron emission tomographyCT scan informationCoronary inflammationCoronary syndromeArtery diseaseCardiac surgeryValidation cohortCoronary arteryMultiple disease statesTissue inflammation