2005
Delayed Arteriogenesis in Hypercholesterolemic Mice
Tirziu D, Moodie KL, Zhuang ZW, Singer K, Helisch A, Dunn JF, Li W, Singh J, Simons M. Delayed Arteriogenesis in Hypercholesterolemic Mice. Circulation 2005, 112: 2501-2509. PMID: 16230502, DOI: 10.1161/circulationaha.105.542829.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoprotein B-48Apolipoproteins BBlood Flow VelocityDisease Models, AnimalEndothelium, VascularFemoral ArteryHumansIn Vitro TechniquesIschemiaMagnetic Resonance ImagingMiceMice, KnockoutNeovascularization, PhysiologicOligonucleotide Array Sequence AnalysisReceptors, LDLUmbilical VeinsConceptsFemoral artery ligationControl miceLaser Doppler imagingArtery ligationTissue perfusionDay 7Doppler imagingReceptor 1Strain-matched control miceVascular cell adhesion molecule-1Monocyte/macrophage influxCell adhesion molecule-1Hypercholesterolemic low-density lipoproteinDistal limb perfusionMacrophage scavenger receptor 1Growth factor therapyIschemia-induced angiogenesisRestoration of perfusionAdhesion molecule-1Arterial blood flowHypoxia-inducible factor-1alphaLow-density lipoproteinScavenger receptor 1Controls 3 daysFactor therapy
1996
Increased macrophage uptake of irreversibly glycated albumin modified-low density lipoproteins of normal and diabetic subjects is mediated by non-saturable mechanisms
Dobrian A, Lazar V, Tirziu D, Simionescu M. Increased macrophage uptake of irreversibly glycated albumin modified-low density lipoproteins of normal and diabetic subjects is mediated by non-saturable mechanisms. Biochimica Et Biophysica Acta 1996, 1317: 5-14. PMID: 8876621, DOI: 10.1016/0925-4439(96)00017-8.Peer-Reviewed Original ResearchConceptsAGE-AlbAdvanced glycosylation end productsDiabetic subjectsDensity lipoproteinAGE-albuminModified-low density lipoproteinsMacrophage uptakeOxidative-antioxidative balanceIndependent risk factorNon-saturable pathwayLow-density lipoproteinNon-saturable mechanismReceptor-mediated uptakeGlycosylation end productsLevel of glycationDiabetes mellitusDiabetic stateRisk factorsAtherosclerotic plaquesLipid peroxidesAcetylated LDLPeritoneal macrophagesReceptor pathwayLipoproteinDLDL
1993
Pathobiochemical Changes of the Arterial Wall at the Inception of Atherosclerosis
Simionescu N, Sima A, Dobrian A, Tirziu D, Simionescu M. Pathobiochemical Changes of the Arterial Wall at the Inception of Atherosclerosis. Current Topics In Pathology 1993, 87: 1-45. PMID: 8125021, DOI: 10.1007/978-3-642-76849-1_1.Peer-Reviewed Original ResearchConceptsLow-density lipoproteinPotential therapeutic implicationsCerebral infarctionSerum cholesterolLipid infiltrationLDL metabolismPathogenic factorsPathobiochemical changesTherapeutic implicationsAtherosclerosisLDL receptorArterial wallArtery wallCardiovascular researchMolecular mechanismsMultiplicity of factorsCellular eventsLines of investigationInfarctionAtherogenesisPathogenesis