Featured Publications
Outcomes and Care Quality Metrics for Women of Reproductive Age Living With Rheumatic Heart Disease in Uganda
Chang A, Nabbaale J, Okello E, Ssinabulya I, Barry M, Beaton A, Webel A, Longenecker C. Outcomes and Care Quality Metrics for Women of Reproductive Age Living With Rheumatic Heart Disease in Uganda. Journal Of The American Heart Association 2020, 9: e015562. PMID: 32295465, PMCID: PMC7428530, DOI: 10.1161/jaha.119.015562.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAnticoagulantsComorbidityFemaleHealthcare DisparitiesHumansMaleMedication AdherenceOutcome and Process Assessment, Health CareQuality Indicators, Health CareRegistriesReproductive HealthRetention in CareRetrospective StudiesRheumatic Heart DiseaseRisk AssessmentRisk FactorsSex FactorsTime FactorsTreatment OutcomeUgandaWomen's HealthYoung AdultConceptsRheumatic heart diseaseWomen of reproductive ageHeart diseaseReproductive ageClinical rheumatic heart diseaseRheumatic Heart Disease RegistryAdherence to guideline-based therapyNew York Heart Association class III-IV heart failurePrescription of warfarinRisk of cardiovascular complicationsCox proportional hazards modelsProportional hazards modelRetrospective cohort studyGuideline-based therapyAdherence ratesDisease RegistryCohort studyAnticoagulant prescriptionSub-Saharan AfricaAnticoagulant useCardiovascular complicationsClinical outcomesCompare comorbiditiesHazards modelHeart failure
2023
Effectiveness of a community health worker-led low-sodium salt intervention to reduce blood pressure in rural Bangladesh: protocol for a cluster randomized controlled trial
Chang A, Rahman M, Talukder A, Shah H, Mridha M, Hasan M, Sarker M, Geldsetzer P. Effectiveness of a community health worker-led low-sodium salt intervention to reduce blood pressure in rural Bangladesh: protocol for a cluster randomized controlled trial. Trials 2023, 24: 480. PMID: 37501102, PMCID: PMC10375753, DOI: 10.1186/s13063-023-07518-3.Peer-Reviewed Original ResearchConceptsLow-sodium salt substituteCommunity health workersCluster randomized controlled trialHealth workersRural BangladeshImplementing health interventionsBackgroundHigh blood pressureMonths post-interventionBlood pressureExcessive salt consumptionMiddle-income countriesRandomized controlled trialsBlood pressure improvementPublic health problemHigh blood pressureLow-sodium saltPost-interventionCommunity healthHealth interventionsMortality reductionSalt consumptionHealth consequencesHealth problemsBlood pressure-lowering interventionsControlled trials
2017
IL6 Signaling in Peripheral Blood T Cells Predicts Clinical Outcome in Breast Cancer
Wang L, Miyahira A, Simons D, Lu X, Chang A, Wang C, Suni M, Maino V, Dirbas F, Yim J, Waisman J, Lee P. IL6 Signaling in Peripheral Blood T Cells Predicts Clinical Outcome in Breast Cancer. Cancer Research 2017, 77: 1119-1126. PMID: 27879265, PMCID: PMC5334262, DOI: 10.1158/0008-5472.can-16-1373.Peer-Reviewed Original ResearchConceptsPeripheral blood T cellsBreast cancer patientsBlood T cellsCancer patientsT cellsIL6 levelsWorse relapse-free survivalPlasma IL6 levelsCancer cellsRelapse-free survivalSerum IL6 levelsAnti-inflammatory propertiesHost immune responseInvolved downregulationClinical outcomesPredictive biomarkersImmune responsePleiotropic cytokinePatientsIL6Cancer ResCancer progressionSurvivalDiagnosisCells
2013
Spatial organization of dendritic cells within tumor draining lymph nodes impacts clinical outcome in breast cancer patients
Chang A, Bhattacharya N, Mu J, Setiadi A, Carcamo-Cavazos V, Lee G, Simons D, Yadegarynia S, Hemati K, Kapelner A, Ming Z, Krag D, Schwartz E, Chen D, Lee P. Spatial organization of dendritic cells within tumor draining lymph nodes impacts clinical outcome in breast cancer patients. Journal Of Translational Medicine 2013, 11: 242. PMID: 24088396, PMCID: PMC3852260, DOI: 10.1186/1479-5876-11-242.Peer-Reviewed Original ResearchConceptsBreast cancer patientsLymph nodesCancer patientsImmune cellsT cellsDendritic cellsIntra-mammary lymph nodesAnti-tumor immune responseDC cancer vaccinesKaplan-Maier analysisDisease-free survivalLog-rank testClinical outcome analysisT cell interactionsIntra-group comparisonInter-group comparisonMann-Whitney testDC clustersBackgroundDendritic cellsDC clusteringClinical outcomesCancer vaccinesSurvival outcomesDC functionNon-parametric Mann-Whitney test