Andrew Y. Chang, MD, PhD
Assistant Professor of Medicine (Cardiovascular Medicine)Cards
About
Research
Publications
Featured Publications
Aging Hearts in a Hotter, More Turbulent World: The Impacts of Climate Change on the Cardiovascular Health of Older Adults
Chang A, Tan A, Nadeau K, Odden M. Aging Hearts in a Hotter, More Turbulent World: The Impacts of Climate Change on the Cardiovascular Health of Older Adults. Current Cardiology Reports 2022, 24: 749-760. PMID: 35438387, PMCID: PMC9017408, DOI: 10.1007/s11886-022-01693-6.Peer-Reviewed Original ResearchConceptsOlder adultsDisproportionate health burdenLow socioeconomic statusAging populationPolicy-level interventionsEthnic minority groupsCardiovascular risk factorsMultiple environmental hazardsSocioeconomic statusCardiovascular healthHeart healthHealth burdenRisk factorsCardiovascular wellbeingCardiovascular diseaseReviewClimate changeMinority groupsPhysiological vulnerabilityIntensifying air pollutionAdultsHealthImpacts of climate changeData sourcesPoor outcomeAir pollutionMortality Along the Rheumatic Heart Disease Cascade of Care in Uganda
Chang A, Barry M, Bendavid E, Watkins D, Beaton A, Lwabi P, Ssinabulya I, Longenecker C, Okello E. Mortality Along the Rheumatic Heart Disease Cascade of Care in Uganda. Circulation Cardiovascular Quality And Outcomes 2022, 15: e008445. PMID: 35041475, DOI: 10.1161/circoutcomes.121.008445.Peer-Reviewed Original ResearchThe Need to Expand the Framework of Environmental Determinants of Cardiovascular Health From Climate Change to Planetary Health
Chang A, Barry M, Harrington R. The Need to Expand the Framework of Environmental Determinants of Cardiovascular Health From Climate Change to Planetary Health. Circulation 2021, 143: 2029-2031. PMID: 34029138, DOI: 10.1161/circulationaha.120.051892.Peer-Reviewed Original ResearchOutcomes and Care Quality Metrics for Women of Reproductive Age Living With Rheumatic Heart Disease in Uganda
Chang A, Nabbaale J, Okello E, Ssinabulya I, Barry M, Beaton A, Webel A, Longenecker C. Outcomes and Care Quality Metrics for Women of Reproductive Age Living With Rheumatic Heart Disease in Uganda. Journal Of The American Heart Association 2020, 9: e015562. PMID: 32295465, PMCID: PMC7428530, DOI: 10.1161/jaha.119.015562.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAnticoagulantsComorbidityFemaleHealthcare DisparitiesHumansMaleMedication AdherenceOutcome and Process Assessment, Health CareQuality Indicators, Health CareRegistriesReproductive HealthRetention in CareRetrospective StudiesRheumatic Heart DiseaseRisk AssessmentRisk FactorsSex FactorsTime FactorsTreatment OutcomeUgandaWomen's HealthYoung AdultConceptsRheumatic heart diseaseWomen of reproductive ageHeart diseaseReproductive ageClinical rheumatic heart diseaseRheumatic Heart Disease RegistryAdherence to guideline-based therapyNew York Heart Association class III-IV heart failurePrescription of warfarinRisk of cardiovascular complicationsCox proportional hazards modelsProportional hazards modelRetrospective cohort studyGuideline-based therapyAdherence ratesDisease RegistryCohort studyAnticoagulant prescriptionSub-Saharan AfricaAnticoagulant useCardiovascular complicationsClinical outcomesCompare comorbiditiesHazards modelHeart failureMotivations of women in Uganda living with rheumatic heart disease: A mixed methods study of experiences in stigma, childbearing, anticoagulation, and contraception
Chang A, Nabbaale J, Nalubwama H, Okello E, Ssinabulya I, Longenecker C, Webel A. Motivations of women in Uganda living with rheumatic heart disease: A mixed methods study of experiences in stigma, childbearing, anticoagulation, and contraception. PLOS ONE 2018, 13: e0194030. PMID: 29590159, PMCID: PMC5874006, DOI: 10.1371/journal.pone.0194030.Peer-Reviewed Original ResearchConceptsWomen of childbearing ageRheumatic heart diseaseFocus groupsLack of health system resourcesLimited health literacyQualitative descriptive methodologyHealth system resourcesHeart diseaseMixed methods studyMiddle-income countriesMale partnersChildbearing ageHealth literacyPatient empowermentWomen of reproductive ageAbandonment of patientsHealth programsPremature mortalitySide effects of contraceptivesDescriptive methodologyConsiderable stigmaIncreased risk of cardiovascular complicationsQualitative studyRisk of cardiovascular complicationsLMICsThe impact of novel coronavirus COVID‐19 on noncommunicable disease patients and health systems: a review
Chang A, Cullen M, Harrington R, Barry M. The impact of novel coronavirus COVID‐19 on noncommunicable disease patients and health systems: a review. Journal Of Internal Medicine 2020, 289: 450-462. PMID: 33020988, PMCID: PMC7675448, DOI: 10.1111/joim.13184.Peer-Reviewed Original ResearchConceptsHealth system factorsNoncommunicable disease patientsNoncommunicable diseasesHealth systemLevels of health systemsSystemic factorsCare of patientsDisease-specific factorsPublic health measuresCare providersNCD patientsDisproportionate burdenHealth measuresCOVID-19Society statementEndocrine disordersPatientsCareLong-term effectsDisease patientsHealthDiseasePandemic disruptionCoronavirus diseaseProvidersCost-effectiveness of Canakinumab for Prevention of Recurrent Cardiovascular Events
Sehested T, Bjerre J, Ku S, Chang A, Jahansouz A, Owens D, Hlatky M, Goldhaber-Fiebert J. Cost-effectiveness of Canakinumab for Prevention of Recurrent Cardiovascular Events. JAMA Cardiology 2019, 4: 128-135. PMID: 30649147, PMCID: PMC6439626, DOI: 10.1001/jamacardio.2018.4566.Peer-Reviewed Original ResearchConceptsQuality-adjusted life yearsCost-effectiveness ratioIncremental cost-effectiveness ratioRecurrent cardiovascular eventsHealth-related quality of lifeStandard of careCanakinumab Anti-inflammatory Thrombosis Outcomes StudyHs-CRP levelsLung cancer incidenceHealth-related qualityMyocardial infarctionCardiovascular eventsRate of recurrent MIHealth care sector perspectiveReduced all-cause mortalityQuality of lifeAll-cause mortalityCost-effectiveUS health care sector perspectiveHs-CRPCancer incidenceRisk of recurrent cardiovascular eventsMain OutcomesHigh-sensitivity C-reactive proteinSubstantial price reductionsAssociation of PM(2.5) With Cardiac Mechanics Using Speckle-Tracking Echocardiography in the Cardiovascular Health Study.
Chang AY, Kaufman JD, Tan AX, Shah SJ, Patel RB, Margolis H, Psaty BM, Gardin JM, Al-Kindi S, Austin TR, Odden MC. Association of PM(2.5) With Cardiac Mechanics Using Speckle-Tracking Echocardiography in the Cardiovascular Health Study. JACC Cardiovasc Imaging 2025, 18: 741-743. PMID: 40243973, DOI: 10.1016/j.jcmg.2025.01.016.Peer-Reviewed Original Research
2025
Association of ambient temperature and blood pressure in the Jackson Heart Study.
Tan AX, Chang AY, Shimbo D, Bress A, Sims M, Odden MC. Association of ambient temperature and blood pressure in the Jackson Heart Study. J Hum Hypertens 2025, 39: 415-421. PMID: 40374966, DOI: 10.1038/s41371-025-01026-4.Peer-Reviewed Original ResearchLongitudinal Evaluation of Immune Checkpoint Inhibitor-Induced Fatigue Syndrome by Rest, Stress, and Speckle-Tracking Strain Echocardiography.
Tsai KK, Chang AY, Abouzeid CM, Aras MA, Fang Q, Bibby D, Haghighat L, Hilton JF, Daud AI, Schiller NB. Longitudinal Evaluation of Immune Checkpoint Inhibitor-Induced Fatigue Syndrome by Rest, Stress, and Speckle-Tracking Strain Echocardiography. Echocardiography 2025, 42: e70158. PMID: 40198654, DOI: 10.1111/echo.70158.Peer-Reviewed Original Research
Teaching & Mentoring
Mentoring
Marilyn Ndukwe, MD
Postdoc2024 - PresentYoon Doh, MD
Medical student2023 - 2024Cory Sejo, MD
Postdoc2023 - 2024Natasha Mehta, MD
Postdoc2023 - 2024
Clinical Care
Overview
Andrew Y. Chang, MD, PhD, is a cardiologist who specializes in cardiovascular medicine and cardiac imaging. He provides care for patients with a variety of heart conditions, using advanced techniques such as echocardiography, which is an ultrasound-based method to visualize the structure and function of the heart. Dr. Chang has particular expertise in guiding minimally invasive procedures to repair or replace heart valves using real-time imaging, reducing the need for open-heart surgery.
As an assistant professor of medicine at Yale School of Medicine, Dr. Chang’s research explores how environmental factors—including climate change—affect heart health. He investigates ways to use digital data, such as information collected from electronic health records and wearable devices, to identify harmful environmental exposures and develop strategies to reduce their impact on cardiovascular health.
Dr. Chang earned his medical and doctoral degrees from Stanford University, where he also completed his internal medicine residency, chief residency, and a fellowship in cardiology. He then completed advanced fellowship training in echocardiography at the University of California San Francisco.
Clinical Specialties
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Echocardiogram
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Cardiovascular Medicine
789 Howard Ave., Section of Cardiovascular Medicine
New Haven, CT 06519
United States
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