Spatial organization of dendritic cells within tumor draining lymph nodes impacts clinical outcome in breast cancer patients
Chang A, Bhattacharya N, Mu J, Setiadi A, Carcamo-Cavazos V, Lee G, Simons D, Yadegarynia S, Hemati K, Kapelner A, Ming Z, Krag D, Schwartz E, Chen D, Lee P. Spatial organization of dendritic cells within tumor draining lymph nodes impacts clinical outcome in breast cancer patients. Journal Of Translational Medicine 2013, 11: 242. PMID: 24088396, PMCID: PMC3852260, DOI: 10.1186/1479-5876-11-242.Peer-Reviewed Original ResearchConceptsBreast cancer patientsLymph nodesCancer patientsImmune cellsT cellsDendritic cellsIntra-mammary lymph nodesAnti-tumor immune responseDC cancer vaccinesKaplan-Maier analysisDisease-free survivalLog-rank testClinical outcome analysisT cell interactionsIntra-group comparisonInter-group comparisonMann-Whitney testDC clustersBackgroundDendritic cellsDC clusteringClinical outcomesCancer vaccinesSurvival outcomesDC functionNon-parametric Mann-Whitney test