Sung Eun Wang
Associate Research Scientist in GeneticsCards
About
Research
Publications
2024
Newly developed oral bioavailable EHMT2 inhibitor as a potential epigenetic therapy for Prader-Willi syndrome
Wang S, Xiong Y, Jang M, Park K, Donahue M, Velez J, Jin J, Jiang Y. Newly developed oral bioavailable EHMT2 inhibitor as a potential epigenetic therapy for Prader-Willi syndrome. Molecular Therapy 2024, 32: 2662-2675. PMID: 38796700, DOI: 10.1016/j.ymthe.2024.05.034.Peer-Reviewed Original ResearchPrader-Willi syndromeEpigenetic therapyMouse modelChromosome 15q11-q13 regionPWS mouse modelFirst-in-class inhibitorEfficacy of oral administrationPoor oral bioavailabilityPotential epigenetic therapiesReduction of H3K9me2Paternally expressed genesOral bioavailabilityIntraperitoneal routeOral administrationPerinatal lethalityTherapeutic benefitBrain penetrationMolecular efficacyPatient fibroblastsEpigenetic modulationGenomic disordersMaternal chromosomeBrain permeabilityLiver tissueCandidate genes
2023
Novel epigenetic molecular therapies for imprinting disorders
Wang S, Jiang Y. Novel epigenetic molecular therapies for imprinting disorders. Molecular Psychiatry 2023, 28: 3182-3193. PMID: 37626134, PMCID: PMC10618104, DOI: 10.1038/s41380-023-02208-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsActive alleleImprinting disordersMolecular mechanismsGenome editing approachesEpigenetic-based therapiesUnique molecular mechanismGenomic imprinting disordersImprinted genesGenome editingMolecular approachesEditing approachesInactive allelesNew therapeutic strategiesAllelesSmall moleculesMolecular therapyTherapeutic strategiesAbnormal kynurenine level contributes to the pathological bone features of ankylosing spondylitis
Jeon C, Jang Y, Lee S, Weon S, Park H, Lee S, Oh Y, Choi S, Wang S, Kim T, Sung I, Jo S. Abnormal kynurenine level contributes to the pathological bone features of ankylosing spondylitis. International Immunopharmacology 2023, 118: 110132. PMID: 37023698, DOI: 10.1016/j.intimp.2023.110132.Peer-Reviewed Original ResearchConceptsModified Stoke Ankylosing Spondylitis Spinal ScoreKyn levelsMouse osteoclast precursorsSera levelsAnkylosing spondylitisStoke Ankylosing Spondylitis Spinal ScoreAS groupDisease activity of ASKyn treatmentOsteoclast formationOsteoclast precursorsTRAP-positive osteoclast formationOsteoblast differentiationSystemic bone lossRANKL-mediated osteoclast differentiationBone formationBone mineralizationCell proliferationFeatures of ankylosing spondylitisOsteoclast differentiation markersRANKL-mediated osteoclastogenesisMRNA expression markersActivity of ASAlkaline phosphateKynurenine levels
2022
Epigenetic Epidemiology of Autism and Other Neurodevelopmental Disorders
Wang S, Jiang Y. Epigenetic Epidemiology of Autism and Other Neurodevelopmental Disorders. 2022, 405-426. DOI: 10.1007/978-3-030-94475-9_17.ChaptersEpigenome-wide association studiesAbnormal DNA methylationDNA methylationHistone modificationsTissue-specific patternsNeurodevelopmental disordersEpigenetic regulationEpigenetic epidemiologyEmbryonic developmentEpigenetic dysregulationGenetic lociEpigenetic reprogramingAssociation studiesMethylationRecent technical advancesEnvironmental factorsRegion analysisEpimutationsReprogramingEtiology of NDDIntellectual disabilityLociTechnical advancesAllelesRegulation
2021
LGI1 governs neuritin-mediated resilience to chronic stress
Lee S, Kim N, Choi M, Ko S, Wang S, Jo H, Seo J, Kim Y, Kim H, Lee H, Kim J, Son H. LGI1 governs neuritin-mediated resilience to chronic stress. Neurobiology Of Stress 2021, 15: 100373. PMID: 34401409, PMCID: PMC8350063, DOI: 10.1016/j.ynstr.2021.100373.Peer-Reviewed Original ResearchLeucine-rich glioma-inactivated protein 1Chronic unpredictable stressLGI1 expressionAntidepressant-like behaviorHippocampus of miceHistone deacetylase 5 (HDAC5) phosphorylationDevelopment of CNSInsulin receptor inhibitorNeuronal atrophyFlox/Unpredictable stressReceptor inhibitorsChronic stressNeuritinHDAC5 phosphorylationProtein 1Pathological depressionMetastasis suppressorEndogenous proteinsNeurite outgrowthMiceDepressionStress resilienceCritical roleExpression
2019
Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2
Wang S, Ko S, Jo S, Jo H, Han J, Kim Y, Son H. Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2. Experimental Neurobiology 2019, 28: 537-546. PMID: 31495082, PMCID: PMC6751865, DOI: 10.5607/en.2019.28.4.537.Peer-Reviewed Original ResearchPlasticity-related genesSynaptic plasticity-related genesLysine N-methyltransferase 2Cellular oxidative stress responseDepression-like behaviorSilent information regulator 2Oxidative stress responseDownregulation of SIRT2SIRT2 expressionTranscriptional silencingKnockdown of SIRT2Protein stabilityRegulator 2Target proteinsChronic stressStress responseHippocampus-dependent cognitive functionDependent deacetylaseGenesBiochemical analysisStress-induced decreaseSIRT2Reduces ExpressionExpressionMood disordersPotential of Epigenetic Therapy for Prader-Willi Syndrome
Wang SE, Jiang YH. Potential of Epigenetic Therapy for Prader-Willi Syndrome. Trends In Pharmacological Sciences 2019, 40: 605-608. PMID: 31353046, DOI: 10.1016/j.tips.2019.07.002.Peer-Reviewed Original ResearchEpigenetic therapy of Prader–Willi syndrome
Kim Y, Wang SE, Jiang YH. Epigenetic therapy of Prader–Willi syndrome. Translational Research 2019, 208: 105-118. PMID: 30904443, PMCID: PMC6527448, DOI: 10.1016/j.trsl.2019.02.012.Peer-Reviewed Original ResearchConceptsPWS mouse modelEpigenetic-based therapiesMaternal chromosomesImprinted gene regulationEHMT2/G9aLysine 9 methyltransferasePatient-derived fibroblastsPrader-Willi syndromeGene regulationMethyltransferase SETDB1Epigenetic mechanismsSmall molecule librariesPWS genesHigh-content screeningSame genePerinatal lethalityEpigenetic therapyFusion proteinMolecular mechanismsG9a inhibitorChromosomesSNORD116 clusterGenesMolecular defectsPatient iPSCTransient receptor potential melastatin 2 governs stress-induced depressive-like behaviors
Ko SY, Wang SE, Lee HK, Jo S, Han J, Lee SH, Choi M, Jo HR, Seo JY, Jung SJ, Son H. Transient receptor potential melastatin 2 governs stress-induced depressive-like behaviors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 1770-1775. PMID: 30642955, PMCID: PMC6358711, DOI: 10.1073/pnas.1814335116.Peer-Reviewed Original ResearchConceptsMajor depressive disorderChronic unpredictable stressReactive oxygen speciesStress-induced depressive-like behaviorTransient receptor potential melastatin 2Antidepressant-like behaviorDepressive-like behaviorStress-induced depressionEnvironmental risk factorsHippocampal tissue samplesHistone deacetylase 5Risk factorsDepressive disorderUnpredictable stressPermeable cation channelSynapsin 1Animal modelsType 2Calpain activationSynaptic functionChronic stressMRNA expressionCation channelsTissue samplesPossible targets
2018
Regulation of osteoblasts by alkaline phosphatase in ankylosing spondylitis
Jo S, Han J, Lee YL, Yoon S, Lee J, Wang SE, Kim T. Regulation of osteoblasts by alkaline phosphatase in ankylosing spondylitis. International Journal Of Rheumatic Diseases 2018, 22: 252-261. PMID: 30415492, DOI: 10.1111/1756-185x.13419.Peer-Reviewed Original ResearchConceptsHealthy controlsPrimary CTAS patientsAge-matched healthy controlsRheumatoid arthritis patientsAlkaline phosphatase levelsPossible therapeutic targetOsteoblast differentiationAlkaline phosphataseALP activityRunt-related transcription factor 2RA groupArthritis patientsMale patientsPrimary diseaseSpinal ankylosisRegulation of osteoblastSerum ALPPhosphatase levelsTherapeutic targetALP levelsTranscription factor 2Master transcriptional factorPatientsOsteoblastic activity