Kari Price
Associate Research Scientist in GeneticsCards
About
Research
Publications
2023
Evolutionarily conserved midbody remodeling precedes ring canal formation during gametogenesis
Price K, Tharakan D, Cooley L. Evolutionarily conserved midbody remodeling precedes ring canal formation during gametogenesis. Developmental Cell 2023, 58: 474-488.e5. PMID: 36898376, PMCID: PMC10059090, DOI: 10.1016/j.devcel.2023.02.008.Peer-Reviewed Original ResearchConceptsCanal formationStable intercellular bridgesGerm cell divisionMidbody ringTime-lapse imagingFemale germlineCell cytokinesisDrosophila malesRing canalsComplete cytokinesisKinase functionCell divisionCytokinesis eventsBroad functionsCytokinesisIntercellular bridgesExtensive remodelingMidbodyDrosophilaBiological systemsDisease statesImportant insightsGametogenesisGermlineProtein
2021
The intrinsically disordered protein SPE-18 promotes localized assembly of MSP in Caenorhabditis elegans spermatocytes
Price K, Presler M, Uyehara C, Shakes D. The intrinsically disordered protein SPE-18 promotes localized assembly of MSP in Caenorhabditis elegans spermatocytes. Development 2021, 148: dev195875. PMID: 33558389, PMCID: PMC7938801, DOI: 10.1242/dev.195875.Peer-Reviewed Original ResearchConceptsMajor sperm proteinMSP assemblyWild-type spermatocytesMutant spermatocytesCaenorhabditis elegansCytoskeletal controlHaploid spermSPE-6Sperm proteinsUnappreciated complexityMeiotic divisionCytoskeletal elementsSpecialized cellsAssembly/Fibrous bodyMeiosisProteinSpermatocytesCellular structureAssemblyParacrystalline structuresElegansCellsLocalizesSperm motility
2020
Drosophila sperm development and intercellular cytoplasm sharing through ring canals do not require an intact fusome
Kaufman RS, Price KL, Mannix KM, Ayers KM, Hudson AM, Cooley L. Drosophila sperm development and intercellular cytoplasm sharing through ring canals do not require an intact fusome. Development 2020, 147: dev190140. PMID: 33033119, PMCID: PMC7687857, DOI: 10.1242/dev.190140.Peer-Reviewed Original ResearchConceptsRing canalsSperm developmentPost-meiotic haploid spermatidsGerm cellsGermline ring canalsAnimal germ cellsQuality control surveillanceLarge cytoplasmic structuresCytoplasmic informationDiploid spermatogoniaHaploid spermatidsSpecialized organellesIncomplete cytokinesisIntercellular movementCell divisionEndogenous proteinsFusomeCytoplasmic structuresIntercellular bridgesMale fertilityIntercellular trafficSpermatogenesisCellsCytokinesisNormal conditions
2017
LET-99 functions in the astral furrowing pathway, where it is required for myosin enrichment in the contractile ring
Price K, Rose L. LET-99 functions in the astral furrowing pathway, where it is required for myosin enrichment in the contractile ring. Molecular Biology Of The Cell 2017, 28: 2360-2373. PMID: 28701343, PMCID: PMC5576900, DOI: 10.1091/mbc.e16-12-0874.Peer-Reviewed Original Research
2015
Dynactin-dependent cortical dynein and spherical spindle shape correlate temporally with meiotic spindle rotation in Caenorhabditis elegans
Crowder M, Flynn J, McNally K, Cortes D, Price K, Kuehnert P, Panzica M, Andaya A, Leary J, McNally F. Dynactin-dependent cortical dynein and spherical spindle shape correlate temporally with meiotic spindle rotation in Caenorhabditis elegans. Molecular Biology Of The Cell 2015, 26: 3030-3046. PMID: 26133383, PMCID: PMC4551317, DOI: 10.1091/mbc.e15-05-0290.Peer-Reviewed Original Research