2023
Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target
Roychowdhury T, Klarin D, Levin M, Spin J, Rhee Y, Deng A, Headley C, Tsao N, Gellatly C, Zuber V, Shen F, Hornsby W, Laursen I, Verma S, Locke A, Einarsson G, Thorleifsson G, Graham S, Dikilitas O, Pattee J, Judy R, Pauls-Verges F, Nielsen J, Wolford B, Brumpton B, Dilmé J, Peypoch O, Juscafresa L, Edwards T, Li D, Banasik K, Brunak S, Jacobsen R, Garcia-Barrio M, Zhang J, Rasmussen L, Lee R, Handa A, Wanhainen A, Mani K, Lindholt J, Obel L, Strauss E, Oszkinis G, Nelson C, Saxby K, van Herwaarden J, van der Laan S, van Setten J, Camacho M, Davis F, Wasikowski R, Tsoi L, Gudjonsson J, Eliason J, Coleman D, Henke P, Ganesh S, Chen Y, Guan W, Pankow J, Pankratz N, Pedersen O, Erikstrup C, Tang W, Hveem K, Gudbjartsson D, Gretarsdottir S, Thorsteinsdottir U, Holm H, Stefansson K, Ferreira M, Baras A, Kullo I, Ritchie M, Christensen A, Iversen K, Eldrup N, Sillesen H, Ostrowski S, Bundgaard H, Ullum H, Burgess S, Gill D, Gallagher K, Sabater-Lleal M, Surakka I, Jones G, Bown M, Tsao P, Willer C, Damrauer S. Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target. Nature Genetics 2023, 55: 1831-1842. PMID: 37845353, PMCID: PMC10632148, DOI: 10.1038/s41588-023-01510-y.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmDevelopment of AAAAortic aneurysmNonhigh-density lipoprotein cholesterolLipid metabolismExtracellular matrix dysregulationClinical risk factorsPreclinical mouse modelsGrowth factor β signalingLipoprotein cholesterolMatrix dysregulationIndependent associationRisk factorsPCSK9 lossDiscovery cohortPolygenic risk scoresRisk lociAAA pathogenesisMouse modelRisk scoreTherapeutic targetAAA riskΒ signalingCommon diseaseMendelian randomization
2018
De novo genome and transcriptome analyses provide insights into the biology of the trematode human parasite Fasciolopsis buski
Biswal DK, Roychowdhury T, Pandey P, Tandon V. De novo genome and transcriptome analyses provide insights into the biology of the trematode human parasite Fasciolopsis buski. PLOS ONE 2018, 13: e0205570. PMID: 30325945, PMCID: PMC6191129, DOI: 10.1371/journal.pone.0205570.Peer-Reviewed Original ResearchConceptsShort interspersed elementsTranscriptome dataTranscriptome analysisDe novo genomeDraft genome assemblyGiant intestinal flukeNext-generation sequencing technologiesGeneration sequencing technologyNovo genomeRNAi pathwayGenome assemblyTransposable elementsEcological diversityImportant biological characteristicsInterspersed elementsGenome analysisProtein kinaseOverall transcriptomeSequencing technologiesTrematode parasitesFasciolopsis buskiEnergy metabolismIntestinal flukesSuitable diagnostic systemOrganisms
2014
De Novo Transcriptome Sequencing and Analysis of the Cereal Cyst Nematode, Heterodera avenae
Kumar M, Gantasala NP, Roychowdhury T, Thakur PK, Banakar P, Shukla RN, Jones MG, Rao U. De Novo Transcriptome Sequencing and Analysis of the Cereal Cyst Nematode, Heterodera avenae. PLOS ONE 2014, 9: e96311. PMID: 24802510, PMCID: PMC4011697, DOI: 10.1371/journal.pone.0096311.Peer-Reviewed Original ResearchConceptsCarbohydrate-active enzymesCereal cyst nematodeCyst nematodeH. avenaeCarbohydrate esterasesGlycoside hydrolasesDe novo transcriptome sequencingGlycosyl transferasesObligate sedentary endoparasitesNovo transcriptome sequencingPre-parasitic juvenilesFirst transcriptome analysisNematode Caenorhabditis elegansPlant-parasitic nematodesComparison of genesAbsence of transmembraneExpression levelsPotato cyst nematodesFree living nematodesSedentary endoparasitesRPKM valuesCaenorhabditis elegansTranscriptome databaseTranscriptome analysisTranscriptome sequencing