Sherry Agabiti, PhD
Associate Research Scientist in GeneticsCards
About
Research
Publications
2026
Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas
Ruiz C, Ge X, McDonnell R, Agabiti S, McQuaid D, Tang A, Kharwa M, Goodell J, del M. Saavedra-Peña R, Wing A, Li G, Medici N, Robert M, Varshney R, Rudolph M, Gorelick F, Wysolmerski J, Canals D, Haley J, Rodeheffer M, Muzumdar M. Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas. Cancer Discovery 2026, 10.1158/2159-8290.cd-25-0734. PMID: 42053430, PMCID: PMC13227558, DOI: 10.1158/2159-8290.cd-25-0734.Peer-Reviewed Original ResearchThis study investigates how dietary fat composition influences pancreatic cancer, showing that monounsaturated fats promote tumor growth while polyunsaturated fats reduce risk by enhancing ferroptosis sensitivity.
2025
Tracing the evolution of single-cell 3D genomes in Kras-driven cancers
Liu M, Jin S, Agabiti S, Jensen T, Yang T, Radda J, Ruiz C, Baldissera G, Rajaei M, Li F, Townsend J, Muzumdar M, Wang S. Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. Nature Genetics 2025, 57: 3075-3087. PMID: 40825871, PMCID: PMC12695640, DOI: 10.1038/s41588-025-02297-w.Peer-Reviewed Original ResearchThis study investigates 3D genome changes in Kras-driven cancers, identifying structural bottlenecks in early progression and potential diagnostic and therapeutic biomarkers.
2019
Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition
Agabiti S, Li J, Dong W, Poe M, Wiemer A. Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition. Cell Death & Disease 2019, 10: 733. PMID: 31570763, PMCID: PMC6768865, DOI: 10.1038/s41419-019-1973-7.Peer-Reviewed Original ResearchToward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant Staphylococcus aureus
Reeve S, Si D, Krucinska J, Yan Y, Viswanathan K, Wang S, Holt G, Frenkel M, Ojewole A, Estrada A, Agabiti S, Alverson J, Gibson N, Priestley N, Wiemer A, Donald B, Wright D. Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant Staphylococcus aureus. ACS Infectious Diseases 2019, 5: 1896-1906. PMID: 31565920, PMCID: PMC7025792, DOI: 10.1021/acsinfecdis.9b00222.Peer-Reviewed Original ResearchProbing the Ligand-Binding Pocket of BTN3A1
Poe M, Agabiti S, Liu C, Li V, Teske K, Hsiao C, Wiemer A. Probing the Ligand-Binding Pocket of BTN3A1. Journal Of Medicinal Chemistry 2019, 62: 6814-6823. PMID: 31268699, PMCID: PMC7701984, DOI: 10.1021/acs.jmedchem.9b00825.Peer-Reviewed Original Research
2017
Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation
Agabiti S, Li J, Wiemer A. Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation. Cell Death & Disease 2017, 8: e2678-e2678. PMID: 28300835, PMCID: PMC5386513, DOI: 10.1038/cddis.2017.101.Peer-Reviewed Original ResearchPhosphinophosphonates and Their Tris-pivaloyloxymethyl Prodrugs Reveal a Negatively Cooperative Butyrophilin Activation Mechanism
Shippy R, Lin X, Agabiti S, Li J, Zangari B, Foust B, Poe M, Hsiao C, Vinogradova O, Wiemer D, Wiemer A. Phosphinophosphonates and Their Tris-pivaloyloxymethyl Prodrugs Reveal a Negatively Cooperative Butyrophilin Activation Mechanism. Journal Of Medicinal Chemistry 2017, 60: 2373-2382. PMID: 28218845, PMCID: PMC5754923, DOI: 10.1021/acs.jmedchem.6b00965.Peer-Reviewed Original Research
2016
Molecular mechanisms linking geranylgeranyl diphosphate synthase to cell survival and proliferation
Agabiti S, Liang Y, Wiemer A. Molecular mechanisms linking geranylgeranyl diphosphate synthase to cell survival and proliferation. Molecular Membrane Biology 2016, 33: 1-11. PMID: 27537059, PMCID: PMC5532733, DOI: 10.1080/09687688.2016.1213432.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements