Shan Xin
Postdoctoral AssociateAbout
Research
Publications
2024
Pan-Cancer Single-Cell and Spatial-Resolved Profiling Reveals the Immunosuppressive Role of APOE+ Macrophages in Immune Checkpoint Inhibitor Therapy.
Liu C, Xie J, Lin B, Tian W, Wu Y, Xin S, Hong L, Li X, Liu L, Jin Y, Tang H, Deng X, Zou Y, Zheng S, Fang W, Cheng J, Dai X, Bao X, Zhao P. Pan-Cancer Single-Cell and Spatial-Resolved Profiling Reveals the Immunosuppressive Role of APOE+ Macrophages in Immune Checkpoint Inhibitor Therapy. Adv Sci (Weinh) 2024, 11: e2401061. PMID: 38569519, DOI: 10.1002/advs.202401061.Peer-Reviewed Original ResearchFatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxia
Peng H, Xin S, Pfeiffer S, Müller C, Merl-Pham J, Hauck S, Harter P, Spitzer D, Devraj K, Varynskyi B, Arzberger T, Momma S, Schick J. Fatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxia. Cell Death & Disease 2024, 15: 286. PMID: 38653992, PMCID: PMC11039673, DOI: 10.1038/s41419-024-06681-y.Peer-Reviewed Original ResearchConceptsFatty acid binding protein 5Cell deathFunction biomarkersProtein 5Death in vitroPositive-feedback loopFerroptotic cell deathLipidomics assaysIndicators of ferroptosisClinical investigationFerroptosis sensitivityWidespread cell deathEctopic expressionMarker antigensReactive speciesCerebral hypoxiaDamaged neuronsProtein dynamicsDeath processCell surfaceHuman pathophysiologyPostmortem patientsIron accumulationInvolvement of lipidsNeurodegenerative diseasesA multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer.
Bao X, Li Q, Chen D, Dai X, Liu C, Tian W, Zhang H, Jin Y, Wang Y, Cheng J, Lai C, Ye C, Xin S, Li X, Su G, Ding Y, Xiong Y, Xie J, Tano V, Wang Y, Fu W, Deng S, Fang W, Sheng J, Ruan J, Zhao P. A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer. Cell Rep Med 2024, 5: 101399. PMID: 38307032, DOI: 10.1016/j.xcrm.2024.101399.Peer-Reviewed Original ResearchGenome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy.
Verma N, Renauer PA, Dong C, Xin S, Lin Q, Zhang F, Glazer PM, Chen S. Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy. BioRxiv 2024 PMID: 38293095, DOI: 10.1101/2024.01.14.575614.Peer-Reviewed Original Research
2023
An immunometabolism subtyping system identifies S100A9(+) macrophage as an immune therapeutic target in colorectal cancer based on multiomics analysis.
Bao X, Wang D, Dai X, Liu C, Zhang H, Jin Y, Tong Z, Li B, Tong C, Xin S, Li X, Wang Y, Liu L, Zhu X, Fu Q, Zheng Y, Deng J, Tian W, Guo T, Zhao P, Chen W, Fang W. An immunometabolism subtyping system identifies S100A9(+) macrophage as an immune therapeutic target in colorectal cancer based on multiomics analysis. Cell Rep Med 2023, 4: 100987. PMID: 36990096, DOI: 10.1016/j.xcrm.2023.100987.Peer-Reviewed Original ResearchPUFAs dictate the balance of power in ferroptosis
Xin S, Schick J. PUFAs dictate the balance of power in ferroptosis. Cell Calcium 2023, 110: 102703. PMID: 36773492, DOI: 10.1016/j.ceca.2023.102703.Peer-Reviewed Original ResearchConceptsLethal lipid peroxidationIron-dependent formFerroptosis susceptibilityLipid remodelingFerroptosis sensitivityFatty acidsFerroptosis resistanceLipid transportersTumor suppressionMembrane lipidsPhospholipid transporterCell deathFerroptosis inductionBiochemical processesFerroptosisLipid metabolismReceptor alphaLipid componentsTransportersPeroxisome proliferatorLipid peroxidationCholesterol estersRegulatorAcidPPARAMassively parallel knock-in engineering of human T cells
Dai X, Park J, Du Y, Na Z, Lam S, Chow R, Renauer P, Gu J, Xin S, Chu Z, Liao C, Clark P, Zhao H, Slavoff S, Chen S. Massively parallel knock-in engineering of human T cells. Nature Biotechnology 2023, 41: 1239-1255. PMID: 36702900, PMCID: PMC11260498, DOI: 10.1038/s41587-022-01639-x.Peer-Reviewed Original Research
2021
MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling
Xin S, Mueller C, Pfeiffer S, Kraft V, Merl-Pham J, Bao X, Feederle R, Jin X, Hauck S, Schmitt-Kopplin P, Schick J. MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling. Cell Death & Differentiation 2021, 29: 670-686. PMID: 34663908, PMCID: PMC8901757, DOI: 10.1038/s41418-021-00883-z.Peer-Reviewed Original ResearchConceptsCell deathDiverse cellular processesLipid droplet dispersionIron-dependent formKey resistance mechanismNovel tetraspaninCellular processesLipid remodelingFerroptosis resistanceLuminal Ca2Endoplasmic reticulumCellular lipidsCell survivalLipid reservoirsDetoxification pathwaysCancer cell linesLipid elongationBiochemical processesMembrane phospholipidsEther lipidsResistance mechanismsCell linesFerroptosisLipid compartmentsSpeciesEvolutionary and functional analyses demonstrate conserved ferroptosis protection by Arabidopsis GPXs in mammalian cells
Song W, Xin S, He M, Pfeiffer S, Cao A, Li H, Schick J, Jin X. Evolutionary and functional analyses demonstrate conserved ferroptosis protection by Arabidopsis GPXs in mammalian cells. The FASEB Journal 2021, 35: e21550. PMID: 33960023, DOI: 10.1096/fj.202000856r.Peer-Reviewed Original ResearchConceptsComprehensive phylogenetic analysisHallmarks of ferroptosisFunctional divergenceMammalian GPxEarly divergencePhylogenetic analysisFerroptosis protectionMammalian cellsFunctional analysisMembrane lipidsMechanistic similaritiesCell deathFerroptosis inductionMouse fibroblastsAntioxidant systemPlantsUnique mechanismOxidative stressSpeciesFatty acidsFerroptosisGPX4DivergenceCellsGPx
2019
Immune Landscape of Invasive Ductal Carcinoma Tumor Microenvironment Identifies a Prognostic and Immunotherapeutically Relevant Gene Signature.
Bao X, Shi R, Zhang K, Xin S, Li X, Zhao Y, Wang Y. Immune Landscape of Invasive Ductal Carcinoma Tumor Microenvironment Identifies a Prognostic and Immunotherapeutically Relevant Gene Signature. Front Oncol 2019, 9: 903. PMID: 31620363, DOI: 10.3389/fonc.2019.00903.Peer-Reviewed Original Research