2023
Convergent coexpression of autism-associated genes suggests some novel risk genes may not be detectable in large-scale genetic studies
Liao C, Moyses-Oliveira M, De Esch C, Bhavsar R, Nuttle X, Li A, Yu A, Burt N, Erdin S, Fu J, Wang M, Morley T, Han L, Consortium C, Dion P, Rouleau G, Zhang B, Brennand K, Talkowski M, Ruderfer D. Convergent coexpression of autism-associated genes suggests some novel risk genes may not be detectable in large-scale genetic studies. Cell Genomics 2023, 3: 100277. PMID: 37082147, PMCID: PMC10112287, DOI: 10.1016/j.xgen.2023.100277.Peer-Reviewed Original ResearchRisk genesNovel risk genesProtein-altering variantsLarge-scale genetic studiesASD risk genesHeritable neurodevelopmental disorderAutism-associated genesCRISPR perturbationsConvergent genesNovel genesTranscriptional consequencesFunctional mutationsGenetic studiesCoexpression patternsDifferential expressionGenesHuman neuronsASD-associationHuman postmortem brainRare variationCoexpressionASD brainNeurodevelopmental disordersPostmortem brainsMutations
2017
The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain
Jiang Y, Loh YE, Rajarajan P, Hirayama T, Liao W, Kassim BS, Javidfar B, Hartley BJ, Kleofas L, Park RB, Labonte B, Ho SM, Chandrasekaran S, Do C, Ramirez BR, Peter CJ, C W JT, Safaie BM, Morishita H, Roussos P, Nestler EJ, Schaefer A, Tycko B, Brennand KJ, Yagi T, Shen L, Akbarian S. The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain. Nature Genetics 2017, 49: 1239-1250. PMID: 28671686, PMCID: PMC5560095, DOI: 10.1038/ng.3906.Peer-Reviewed Original Research