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Kenneth Kidd, PhD

Professor Emeritus of Genetics
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Professor Emeritus of Genetics

Biography

Kenneth K. Kidd received his Ph.D. in Genetics from the University of Wisconsin in 1969. His early training included Drosophila genetics, classical immunogenetics, and population genetics. During his post-doctoral studies in Italy and at Stanford University, he established his reputation in human population genetics. He joined the Genetics faculty at Yale University School of Medicine in 1973 where he has remained and is currently Professor of Genetics, Psychiatry, and Ecology and Evolutionary Biology. At Yale he has pursued research in many areas of human genetics, including medical genetics (studies of neuropsychiatric disorders and simple Mendelian disorders), gene mapping (both physical and genetic), database design for modern genetic data, and a variety of molecular methodologies. More recently, his long-standing interest in human population genetics has been combined with his laboratory's expertise in molecular technology to examine human genome diversity at the DNA level. He is also responsible for ALFRED, the ALlele FREquency Database, a web accessible compilation of allele frequency data for DNA polymorphisms on anthropologically defined human population.

During his career, Dr. Kidd has published more than 450 scientific articles in a broad range of subjects including population genetics, cancer and neuropsychiatric genetics, gene mapping, molecular methodology, genetic databases, and human diversity. He is one of the co-authors of a paper selected as the best biomedical paper of the year by The Lancet, a leading British medical journal. This and other publication by Dr. Kidd can be found on his website http://info.med.yale.edu/genetics/kkidd. He is a certified Medical Geneticist by the American Board of Medical Genetics. He has served on several U.S. Government Review and Advisory Committees/Panels, on several editorial boards, and helped organize several international conferences. He is a member of several professional societies and a Fellow of the American Association for the Advancement of Science. Among his other awards, he has been recognized by the U.S. Federal Bureau of Investigation and the National Institute of Justice for his contributions toward acceptance of DNA methodologies in the courts. He recently served on national advisory panels for DNA identification of victims of the World Trade Center attack and victims of Katrina.

Appointments

Education & Training

PhD
University of Wisconsin (1969)

Research

Overview

Normal DNA sequence variation such as single nucleotide polymorphisms (SNPs), short tandem repeat polymorphisms (STRPs), etc. have made Homo sapiens amenable to many types of genetic analysis. We are using these polymorphisms to study the genes for several inherited disorders, including neuropsychiatric disorders, and working on statistical methods to analyze the data. We are studying these and other polymorphisms genome-wide on DNA samples from many different human populations with an emphasis on understanding the organization of normal variation including studies of linkage disequilibrium and estimates of the distribution of the variation in the entire species. We have established a database, ALFRED, the ALelle FREquency Database, to accumulate allele frequencies of DNA polymorphisms. A current focus is on forensic uses of SNPs.

For the past several years my laboratory has studied the genetics of complex human disorders, those disorders that fail to show a Mendelian pattern but do "run in families". DNA polymorphisms are now being used to search for the genetic loci of major effect in behavioral and other complex disorders. Our previous efforts focused on finding genes responsible for neuropsychiatric disorders, especially Giles de la Tourette Syndrome and schizophrenia. While no locus appears to account for all cases of Tourette Syndrome, we have strong evidence of a predisposing genetic factor on the distal long arm of chromosome 17. Studies are ongoing through collaborations to narrow the region and identify the relevant variant.

We are studying the population genetics of expressed and non-expressed genetic variation at several genes of known neurologic relevance, such as the dopamine receptors D2 and D4 and the enzyme COMT, Catechol-O-methyl transferase. Also, because of their demonstrated relevance to alcoholism we are studying the genes involved in ethanol metabolism, the ADH genes and ALDH2. Understanding the nature of the common normal variation at these loci provides a background for investigating how they might influence normal and abnormal neurologic/metabolic function and susceptibility to psychiatric disorders. The duplicated ADH Class 1 genes are unique to primates and are the focus of molecular evolution studies. Several more evolution-oriented projects are also being pursued. These include theoretical studies as well as studying samples from diverse human populations for DNA polymorphisms. For some genes of interest we are also collecting DNA sequence of other great apes to examine the origins of the human lineage.

The lab's efforts are currently focused on genome diversity among world populations and understanding how that diversity arose. We have accumulated cell lines on individuals from over 45 different populations and plan to increase this resource in the coming years. On a global basis we are finding that the majority of alleles for nuclear DNA polymorphisms are present in most populations around the world, though sub-Saharan African populations have more genetic variation (alleles), in general, than indigenous populations in any other part of the world. We interpret the data to mean that there was a major founder effect and loss of variation associated with the expansion of modern humans out of Africa. Haplotype data collected on all of the populations we are studying are beginning to reveal patterns that provide a better understanding of that founder effect and the recent evolutionary history of modern humans. Recent studies have used these resources to select SNPs that can be useful in forensics, both for individual identification (matching the DNA at a crime scene with a suspect's DNA). Other SNPs are being selected for their value in inference of ancestry from an individual's DNA.

Bioinformatics research, in collaboration with the Yale Center for Medical Informatics, is ongoing in two areas. We are working to improve data management for the extensive marker typing results accumulating on many of the projects. We are also working to improve the utility of data in ALFRED through new search and display modes as well as relevant links to other online sources
  • Gene study using polymorphism of the DNA for several inherited disorders
  • Collaborative study to narrow the region and identify the chromosome involved in Tourette syndrome and Schizophrenia
  • Population genetics of expressed and non-expressed genetic variation at several genes of known neurologic relevance
  • Bioinformatics research to improve data management for extensive marker typing results and improve the utility of data in ALFRED

Medical Subject Headings (MeSH)

Africa; China; Gambia; Genetics; Global Health; India; Neuropsychiatry; Psychiatry

Research at a Glance

Yale Co-Authors

Frequent collaborators of Kenneth Kidd's published research.

Publications

2024

2023

2022

Academic Achievements & Community Involvement

  • activity

    West Africa

  • honor

    Biomedical paper of the Year award

  • honor

    "Profile in DNA Courage" award

  • honor

    Recognition of Your Efforts During Our Decade of DNA, 1988-1998

  • honor

    Carter Lecture and Medal

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