Tamas Horvath, DVM, PhD

• Akiko Iwasaki
• Amy Arnsten
• Andrew Wang
• Anton Bennett
• Carlos Fernandez-Hernando
• Carmen Jane Booth
• Flora Vaccarino
• Gerald I Shulman
• Ismene Petrakis
• John Elsworth
• Leonard Kaczmarek
• Marcelo de Oliveira Dietrich
• Pasko Rakic
• Peter M. Glazer
• Vishwa Deep Dixit
• Xiao-Bing Gao
• Yingqun Huang
• Yury M. Morozov
• Zhongwu Liu

Neuroendocrinology; Obesity; Physiology

• A small-molecule degrader of TET3 as treatment for anorexia nervosa in an animal modelLv H, Catarino J, Li D, Liu B, Gao X, Horvath T, Huang Y. A small-molecule degrader of TET3 as treatment for anorexia nervosa in an animal model. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2300015120. PMID: 37036983, PMCID: PMC10120042, DOI: 10.1073/pnas.2300015120.
• Neonatal loss of FGFR2 in astroglial cells affects locomotion, sociability, working memory, and glia-neuron interactions in miceStevens H, Scuderi S, Collica S, Tomasi S, Horvath T, Vaccarino F. Neonatal loss of FGFR2 in astroglial cells affects locomotion, sociability, working memory, and glia-neuron interactions in mice. Translational Psychiatry 2023, 13: 89. PMID: 36906620, PMCID: PMC10008554, DOI: 10.1038/s41398-023-02372-y.
• Response to: Elevated L1 expression in ataxia telangiectasia likely explained by an RNA-seq batch effectTakahashi T, Stoiljkovic M, Song E, Gao X, Yasumoto Y, Kudo E, Carvalho F, Kong Y, Park A, Shanabrough M, Szigeti-Buck K, Liu Z, Kristant A, Zhang Y, Sulkowski P, Glazer P, Kaczmarek L, Horvath T, Iwasaki A. Response to: Elevated L1 expression in ataxia telangiectasia likely explained by an RNA-seq batch effect. Neuron 2023, 111: 612-613. PMID: 36863323, DOI: 10.1016/j.neuron.2023.02.006.
• Impaired Ghrelin Signaling Does Not Lead to Alterations of Anxiety-like Behaviors in Adult Mice Chronically Exposed to THC during AdolescenceSestan-Pesa M, Shanabrough M, Horvath T, Miletta M. Impaired Ghrelin Signaling Does Not Lead to Alterations of Anxiety-like Behaviors in Adult Mice Chronically Exposed to THC during Adolescence. Biomedicines 2023, 11: 144. PMID: 36672651, PMCID: PMC9855766, DOI: 10.3390/biomedicines11010144.
• Ghrelin Predicts Stimulant and Sedative Effects of Alcohol in Heavy DrinkersRalevski E, Horvath T, Shanabrough M, Newcomb J, Pisani E, Petrakis I. Ghrelin Predicts Stimulant and Sedative Effects of Alcohol in Heavy Drinkers. Alcohol And Alcoholism 2022, 58: 100-106. PMID: 36382470, PMCID: PMC9830489, DOI: 10.1093/alcalc/agac058.
• Impact of TREM2 on hippocampal network oscillations in Tg2576 mice modeling amyloid‐β pathologyStoiljkovic M, Gutierrez K, Kelley C, Horvath T, Hajos M. Impact of TREM2 on hippocampal network oscillations in Tg2576 mice modeling amyloid‐β pathology. Alzheimer's & Dementia 2022, 17 DOI: 10.1002/alz.054379.
• Introduction—Tamas L. HorvathHorváth T, Hirsch J, Molnár Z. Introduction—Tamas L. Horvath. 2022, xix-xxiv. DOI: 10.1016/b978-0-12-818093-8.00025-2.
• Chapter 2 Tamas Horvath: The hunger view on body, brain and behaviorHorváth T, Hirsch J, Molnár Z. Chapter 2 Tamas Horvath: The hunger view on body, brain and behavior. 2022, 67-146. DOI: 10.1016/b978-0-12-818093-8.00009-4.
• Introduction—Zoltán MolnárHorváth T, Hirsch J, Molnár Z. Introduction—Zoltán Molnár. 2022, xiii-xvii. DOI: 10.1016/b978-0-12-818093-8.00017-3.
• Chapter 3 Joy Hirsch: Brain-to-BrainHorváth T, Hirsch J, Molnár Z. Chapter 3 Joy Hirsch: Brain-to-Brain. 2022, 147-181. DOI: 10.1016/b978-0-12-818093-8.00008-2.
• Introduction—Joy HirschHorváth T, Hirsch J, Molnár Z. Introduction—Joy Hirsch. 2022, xxv-xxviii. DOI: 10.1016/b978-0-12-818093-8.00019-7.
• Chapter 1 Zoltán Molnár: the developing brainHorváth T, Hirsch J, Molnár Z. Chapter 1 Zoltán Molnár: the developing brain. 2022, 1-66. DOI: 10.1016/b978-0-12-818093-8.00005-7.
• Learning Weakly Convex Sets in Metric SpacesStadtländer E, Horváth T, Wrobel S. Learning Weakly Convex Sets in Metric Spaces. 2021, 12976: 200-216. DOI: 10.1007/978-3-030-86520-7_13.
• Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in miceRyu S, Shchukina I, Youm YH, Qing H, Hilliard B, Dlugos T, Zhang X, Yasumoto Y, Booth CJ, Fernández-Hernando C, Suárez Y, Khanna K, Horvath TL, Dietrich MO, Artyomov M, Wang A, Dixit VD. Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice. ELife 2021, 10: e66522. PMID: 34151773, PMCID: PMC8245129, DOI: 10.7554/elife.66522.
• Adiponectin preserves metabolic fitness during agingLi N, Zhao S, Zhang Z, Zhu Y, Gliniak CM, Vishvanath L, An YA, Wang MY, Deng Y, Zhu Q, Shan B, Sherwood A, Onodera T, Oz OK, Gordillo R, Gupta RK, Liu M, Horvath TL, Dixit VD, Scherer PE. Adiponectin preserves metabolic fitness during aging. ELife 2021, 10: e65108. PMID: 33904399, PMCID: PMC8099426, DOI: 10.7554/elife.65108.
• The aging rhesus macaque as a potential model for Alzheimer's disease/dementia: An in vivo study of [11C]PIB, [11C]UCB‐j, [18F]MK‐6240 and working memory performanceFang X, Williams G, Castner S, Holden D, Zheng M, Najafzadeh S, Ropchan J, Arnsten A, Horvath T, Carson R. The aging rhesus macaque as a potential model for Alzheimer's disease/dementia: An in vivo study of [11C]PIB, [11C]UCB‐j, [18F]MK‐6240 and working memory performance. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.038467.
• Hypothalamic hunger promoting neurons drive lifeHorvath T. Hypothalamic hunger promoting neurons drive life. Obesity Research & Clinical Practice 2019, 13: 267. DOI: 10.1016/j.orcp.2018.11.091.
• SUN-097 AgRP Neurons Determine Survival in Activity-Based Anorexia ModelMiletta M, Shanabrough M, Sestan-Pesa M, Varela L, Mancini G, Spadaro O, Zeiss C, Dixit V, Dietrich M, Horvath T. SUN-097 AgRP Neurons Determine Survival in Activity-Based Anorexia Model. Journal Of The Endocrine Society 2019, 3: sun-097. PMCID: PMC6553392, DOI: 10.1210/js.2019-sun-097.
• Loss of HAX-1 May Contribute to the Neurodegeneration Caused by a Kv3.3 MutationZhang Y, Varela L, Szigeti-Buck K, Horvath T, Kaczmarek L. Loss of HAX-1 May Contribute to the Neurodegeneration Caused by a Kv3.3 Mutation. Biophysical Journal 2019, 116: 104a. DOI: 10.1016/j.bpj.2018.11.596.
• Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or AdiposityRavussin A, Youm YH, Sander J, Ryu S, Nguyen K, Varela L, Shulman GI, Sidorov S, Horvath TL, Schultze JL, Dixit VD. Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity. Cell Reports 2018, 24: 1085-1092.e6. PMID: 30067966, PMCID: PMC6223120, DOI: 10.1016/j.celrep.2018.06.112.
• Role of Tank-Binding Kinase in Neurodegeneration Produced by Spinocerebellar Ataxia Type 13Zhang Y, Varela L, Horvath T, Kaczmarek L. Role of Tank-Binding Kinase in Neurodegeneration Produced by Spinocerebellar Ataxia Type 13. Biophysical Journal 2017, 112: 405a. DOI: 10.1016/j.bpj.2016.11.2193.
• 4.19 Obesity and Appetite: Central Control MechanismsHorvath T. 4.19 Obesity and Appetite: Central Control Mechanisms. 2017, 369-376. DOI: 10.1016/b978-0-12-803592-4.00085-7.
• How hypothalamus senses and stimulates food intakeHorvath T. How hypothalamus senses and stimulates food intake. Endocrine Abstracts 2016 DOI: 10.1530/endoabs.41.s27.3.
• Novel insights into central regulation of food intakeKoch M, Elmquist J, Morozov Y, Rakic P, Bechmann I, Cowley M, Dietrich M, Diano S, Horvath T. Novel insights into central regulation of food intake. Neuropeptides 2016, 55: 30. DOI: 10.1016/j.npep.2015.11.086.
• Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involutionYoum YH, Horvath TL, Mangelsdorf DJ, Kliewer SA, Dixit VD. Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 1026-1031. PMID: 26755598, PMCID: PMC4743827, DOI: 10.1073/pnas.1514511113.
• Mitochondria in Control of Hypothalamic Metabolic CircuitsNasrallah C, Horvath T. Mitochondria in Control of Hypothalamic Metabolic Circuits. 2015, 186-202. DOI: 10.1002/9781119017127.ch8.
• Regulation of hypothalamic development by maternal nutritionVogt M, Paeger L, Hess S, Steculorum S, Neupert S, Predel R, Kloppenburg P, Horvath T, Bruning J. Regulation of hypothalamic development by maternal nutrition. Endocrine Abstracts 2015 DOI: 10.1530/endoabs.37.s7.2.
• GhrelinMüller T, Nogueiras R, Andermann M, Andrews Z, Anker S, Argente J, Batterham R, Benoit S, Bowers C, Broglio F, Casanueva F, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole P, Cowley M, Cummings D, Dagher A, Diano S, Dickson S, Diéguez C, Granata R, Grill H, Grove K, Habegger K, Heppner K, Heiman M, Holsen L, Holst B, Inui A, Jansson J, Kirchner H, Korbonits M, Laferrère B, LeRoux C, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger P, Schwartz T, Seeley R, Sleeman M, Sun Y, Sussel L, Tong J, Thorner M, van der Lely A, van der Ploeg L, Zigman J, Kojima M, Kangawa K, Smith R, Horvath T, Tschöp M. Ghrelin. Molecular Metabolism 2015, 4: 437-460. PMID: 26042199, PMCID: PMC4443295, DOI: 10.1016/j.molmet.2015.03.005.
• The role of the hypothalamus in the maintenance of energy balance and peripheral glucose controlVarela L, Horvath T. The role of the hypothalamus in the maintenance of energy balance and peripheral glucose control. 2015, 529-537. DOI: 10.1002/9781118387658.ch36.
• Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond FeedingDietrich MO, Zimmer MR, Bober J, Horvath TL. Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding. Cell 2015, 160: 1222-1232. PMID: 25748653, PMCID: PMC4484787, DOI: 10.1016/j.cell.2015.02.024.
• Hypothalamic POMC neurons promote cannabinoid-induced feedingKoch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao XB, Diano S, Horvath TL. Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature 2015, 519: 45-50. PMID: 25707796, PMCID: PMC4496586, DOI: 10.1038/nature14260.
• The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory diseaseYoum YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease. Nature Medicine 2015, 21: 263-269. PMID: 25686106, PMCID: PMC4352123, DOI: 10.1038/nm.3804.
• Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feedingKim JG, Suyama S, Koch M, Jin S, Argente-Arizon P, Argente J, Liu ZW, Zimmer MR, Jeong JK, Szigeti-Buck K, Gao Y, Garcia-Caceres C, Yi CX, Salmaso N, Vaccarino FM, Chowen J, Diano S, Dietrich MO, Tschöp MH, Horvath TL. Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nature Neuroscience 2014, 17: 908-910. PMID: 24880214, PMCID: PMC4113214, DOI: 10.1038/nn.3725.
• Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat FeedingVogt MC, Paeger L, Hess S, Steculorum SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL, Brüning JC. Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding. Cell 2014, 156: 495-509. PMID: 24462248, PMCID: PMC4101521, DOI: 10.1016/j.cell.2014.01.008.
• Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced ObesityDietrich MO, Liu ZW, Horvath TL. Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity. Cell 2013, 155: 188-199. PMID: 24074868, PMCID: PMC4142434, DOI: 10.1016/j.cell.2013.09.004.
• FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food IntakeRen H, Orozco I, Su Y, Suyama S, Gutiérrez-Juárez R, Horvath T, Wardlaw S, Plum L, Arancio O, Accili D. FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake. Cell 2013, 153: 1166. DOI: 10.1016/j.cell.2013.05.010.
• Ghrelin Regulation of Learning, Memory, and NeurodegenerationHorvath T. Ghrelin Regulation of Learning, Memory, and Neurodegeneration. 2012, 171-180. DOI: 10.1007/978-1-61779-903-7_9.
• Neuroendocrine Regulation of Energy BalanceDietrich M, Horvath T. Neuroendocrine Regulation of Energy Balance. 2012, 113-118. DOI: 10.1093/med:psych/9780199738168.003.0016.
• Plasticity of Brain Feeding Circuits in Response to FoodHorvath T. Plasticity of Brain Feeding Circuits in Response to Food. 2012, 61-74. DOI: 10.1007/978-1-4614-3492-4_5.
• Hypothalamic circuits control higher brain functions and impairmentsHorvath T. Hypothalamic circuits control higher brain functions and impairments. Neurology Psychiatry And Brain Research 2012, 18: 61. DOI: 10.1016/j.npbr.2012.02.020.
• Obesity is associated with hypothalamic injury in rodents and humansThaler J, Yi C, Schur E, Guyenet S, Hwang B, Dietrich M, Zhao X, Sarruf D, Izgur V, Maravilla K, Nguyen H, Fischer J, Matsen M, Wisse B, Morton G, Horvath T, Baskin D, Tschöp M, Schwartz M. Obesity is associated with hypothalamic injury in rodents and humans. Journal Of Clinical Investigation 2012, 122: 778-778. PMCID: PMC3266812, DOI: 10.1172/jci62813.
• Neuroendocrine Regulation of Energy MetabolismDietrich M, Horvath T. Neuroendocrine Regulation of Energy Metabolism. Endocrinology And Metabolism 2012, 27: 268-273. DOI: 10.3803/enm.2012.27.4.268.
• Erratum: Corrigendum: Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesityDiano S, Liu Z, Jeong J, Dietrich M, Ruan H, Kim E, Suyama S, Kelly K, Gyengesi E, Arbiser J, Belsham D, Sarruf D, Schwartz M, Bennett A, Shanabrough M, Mobbs C, Yang X, Gao X, Horvath T. Erratum: Corrigendum: Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nature Medicine 2011, 17: 1320-1320. DOI: 10.1038/nm1011-1320a.
• Long term estradiol treatment improves reproductive parameters in leptin deficient female miceLuk J, Horvath T, Johnson J. Long term estradiol treatment improves reproductive parameters in leptin deficient female mice. Fertility And Sterility 2011, 96: s125. DOI: 10.1016/j.fertnstert.2011.07.486.
• F5‐01‐02: A Role for hunger‐promoting neurons in the etiology of neurodegenerationHorvath T. F5‐01‐02: A Role for hunger‐promoting neurons in the etiology of neurodegeneration. Alzheimer's & Dementia 2011, 7: s807-s807. DOI: 10.1016/j.jalz.2011.05.2326.
• Erratum: UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicalsAndrews Z, Liu Z, Walllingford N, Erion D, Borok E, Friedman J, Tschöp M, Shanabrough M, Cline G, Shulman G, Coppola A, Gao X, Horvath T, Diano S. Erratum: UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals. Nature 2009, 459: 736-736. DOI: 10.1038/nature08132.
• HypothalamusGao Q, Horvath T. Hypothalamus. 2009, 1895-1900. DOI: 10.1007/978-3-540-29678-2_2322.
• Hypothalamic circuitry and metabolism: a role for synaptic plasticityHorvath T, Diano S. Hypothalamic circuitry and metabolism: a role for synaptic plasticity. Neuroscience Research 2009, 65: s11. DOI: 10.1016/j.neures.2009.09.1533.
• Ghrelin: an orexigenic signal from the stomachHorvath T. Ghrelin: an orexigenic signal from the stomach. 2008, 266-284. DOI: 10.1017/cbo9780511541643.010.
• Overexpression of UCP2 Protects Thalamic Neurons following Global Ischemia in the MouseDeierborg T, Wieloch T, Diano S, Warden C, Horvath T, Mattiasson G. Overexpression of UCP2 Protects Thalamic Neurons following Global Ischemia in the Mouse. Cerebrovascular And Brain Metabolism Reviews 2008, 28: 1273-1273. DOI: 10.1038/jcbfm.2008.18.
• Rimonabant—a new hope in the treatment of obesity?Abizaid A, Horvath T. Rimonabant—a new hope in the treatment of obesity? Nature Reviews Endocrinology 2006, 2: 370-371. DOI: 10.1038/ncpendmet0218.
• Enhanced PIP3 signaling in POMC neurons causes diet-sensitive obesity as the consequence of neuronal silencing via KATP channel activationPlum L, Ma X, Hampel B, Münzberg H, Shanabrough M, Rother E, Koch L, Janoschek R, Alber J, Belgardt B, Krone W, Horvath T, Ashcroft F, Brüning J. Enhanced PIP3 signaling in POMC neurons causes diet-sensitive obesity as the consequence of neuronal silencing via KATP channel activation. Diabetologie Und Stoffwechsel 2006, 1 DOI: 10.1055/s-2006-943791.
• Unraveling neuronal circuitry regulating energy homeostasis: Plasticity in feeding circuitsAbizaid A, Horvath T. Unraveling neuronal circuitry regulating energy homeostasis: Plasticity in feeding circuits. Drug Discovery Today Disease Models 2005, 2: 191-196. DOI: 10.1016/j.ddmod.2005.08.009.
• The Anatomy of Hypocretin NeuronsHorvath T. The Anatomy of Hypocretin Neurons. 2005, 77-93. DOI: 10.1007/0-387-25446-3_6.
• CPG2A brain- and synapse-specific protein that regulates the endocytosis of glutamate receptorsCOTTRELL J, BOROK E, HORVATH T, NEDIVI E. CPG2A brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors. Neuron 2004, 44: 677-690. DOI: 10.1016/s0896-6273(04)00688-9.
• GhrelinTschöp M, Diano S, Horvath T. Ghrelin. 2004, 150-156. DOI: 10.1016/b0-12-475570-4/01491-8.
• Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and functionLephart E, Lund T, Horvath T. Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and function. Brain Research Reviews 2001, 37: 25-37. PMID: 11744072, DOI: 10.1016/s0165-0173(01)00111-4.
• Minireview: ghrelin and the regulation of energy balance--a hypothalamic perspective.Horvath T, Diano S, Sotonyi P, Heiman M, Tschöp M. Minireview: ghrelin and the regulation of energy balance--a hypothalamic perspective. Endocrinology 2001, 142: 4163-9. PMID: 11564668, DOI: 10.1210/endo.142.10.8490.
• Estrogen Synthetase (Aromatase) Immunohistochemistry Reveals Concordance Between Avian and Rodent Limbic Systems and HypothalamiNaftolin F, Horvath T, Balthazart J. Estrogen Synthetase (Aromatase) Immunohistochemistry Reveals Concordance Between Avian and Rodent Limbic Systems and Hypothalami. Experimental Biology And Medicine 2001, 226: 717-725. PMID: 11520936, DOI: 10.1177/153537020222600802.
• Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleusCowley M, Smart J, Rubinstein M, Cerdán M, Diano S, Horvath T, Cone R, Low M. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 2001, 411: 480-484. PMID: 11373681, DOI: 10.1038/35078085.
• Turnover of Rat Brain Perivascular CellsBechmann I, Kwidzinski E, Kovac A, Simbürger E, Horvath T, Gimsa U, Dirnagl U, Priller J, Nitsch R. Turnover of Rat Brain Perivascular Cells. Experimental Neurology 2001, 168: 242-249. PMID: 11259112, DOI: 10.1006/exnr.2000.7618.
• A GABA-neuropeptide Y (NPY) interplay in LH releaseHorvath T, Pu S, Dube M, Diano S, Kalra S. A GABA-neuropeptide Y (NPY) interplay in LH release. Peptides 2001, 22: 473-481. PMID: 11287104, DOI: 10.1016/s0196-9781(01)00343-6.
• Sexual dimorphism and aromatase in the rat retinaSalyer D, Lund T, Fleming D, Lephart E, Horvath T. Sexual dimorphism and aromatase in the rat retina. Brain Research 2001, 126: 131-136. PMID: 11172896, DOI: 10.1016/s0165-3806(00)00147-4.
• Oestrogen-induced changes in the synaptology of the monkey (Cercopithecus aethiops) arcuate nucleus during gonadotropin feedback.Zsarnovszky A, Horvath T, Garcia-Segura L, Horvath B, Naftolin F. Oestrogen-induced changes in the synaptology of the monkey (Cercopithecus aethiops) arcuate nucleus during gonadotropin feedback. Journal Of Neuroendocrinology 2001, 13: 22-8. PMID: 11123512, DOI: 10.1046/j.1365-2826.2001.00602.x.
• Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and MemoryLeranth C, Roth R, Elsworth J, Naftolin F, Horvath T, Redmond D. Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory. Journal Of Neuroscience 2000, 20: 8604-8609. PMID: 11102464, PMCID: PMC6773080, DOI: 10.1523/jneurosci.20-23-08604.2000.
• Mitochondrial Uncoupling Protein 2 (UCP2) in the Nonhuman Primate Brain and Pituitary*This work was supported by NSF Grant IBN-9728581, NIH Grants NS-36111, MH-59847, RR-00163, HD-29186, and HD-37186.Diano S, Urbanski H, Horvath B, Bechmann I, Kagiya A, Nemeth G, Naftolin F, Warden C, Horvath T. Mitochondrial Uncoupling Protein 2 (UCP2) in the Nonhuman Primate Brain and Pituitary*This work was supported by NSF Grant IBN-9728581, NIH Grants NS-36111, MH-59847, RR-00163, HD-29186, and HD-37186. Endocrinology 2000, 141: 4226-4238. PMID: 11089557, DOI: 10.1210/endo.141.11.7740.
• Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated ratsDube M, Horvath T, Kalra P, Kalra S. Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats. Peptides 2000, 21: 1557-1560. PMID: 11068104, DOI: 10.1016/s0196-9781(00)00311-9.
• AMPA receptors colocalize with neuropeptide-Y- and galanin-containing, but not with dopamine, neurons of the female rat arcuate nucleus: a semiquantitative immunohistochemical colocalization studyZsarnovszky A, Horvath T, Naftolin F, Leranth C. AMPA receptors colocalize with neuropeptide-Y- and galanin-containing, but not with dopamine, neurons of the female rat arcuate nucleus: a semiquantitative immunohistochemical colocalization study. Experimental Brain Research 2000, 133: 532-537. PMID: 10985687, DOI: 10.1007/s002210000425.
• Estrogen effects on tyrosine hydroxylase-immunoreactive cells in the ventral mesencephalon of the female rat: further evidence for the two cell hypothesis of dopamine functionZsarnovszky A, Scalise T, Horvath T, Naftolin F. Estrogen effects on tyrosine hydroxylase-immunoreactive cells in the ventral mesencephalon of the female rat: further evidence for the two cell hypothesis of dopamine function. Brain Research 2000, 868: 363-366. PMID: 10854590, DOI: 10.1016/s0006-8993(00)02323-4.
• Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated ratsJain M, Horvath T, Kalra P, Kalra S. Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats. Peptides 2000, 87: 19-24. PMID: 10710284, DOI: 10.1016/s0167-0115(99)00102-0.
• Brain Uncoupling Protein 2: Uncoupled Neuronal Mitochondria Predict Thermal Synapses in Homeostatic CentersHorvath T, Warden C, Hajos M, Lombardi A, Goglia F, Diano S. Brain Uncoupling Protein 2: Uncoupled Neuronal Mitochondria Predict Thermal Synapses in Homeostatic Centers. Journal Of Neuroscience 1999, 19: 10417-10427. PMID: 10575039, PMCID: PMC6782406, DOI: 10.1523/jneurosci.19-23-10417.1999.
• Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic systemHorvath T, Peyron C, Diano S, Ivanov A, Aston‐Jones G, Kilduff T, van den Pol A. Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. The Journal Of Comparative Neurology 1999, 415: 145-159. PMID: 10545156, DOI: 10.1002/(sici)1096-9861(19991213)415:2<145::aid-cne1>3.0.co;2-2.
• Estrogen receptor β and progesterone receptor mRNA in the intergeniculate leaflet of the female ratHorvath T, Diano S, Sakamoto H, Shughrue P, Merchenthaler I. Estrogen receptor β and progesterone receptor mRNA in the intergeniculate leaflet of the female rat. Brain Research 1999, 844: 196-200. PMID: 10536277, DOI: 10.1016/s0006-8993(99)01759-x.
• Estrogen receptor-α in the raphe serotonergic and supramammillary area calretinin-containing neurons of the female ratLeranth C, Shanabrough M, Horvath T. Estrogen receptor-α in the raphe serotonergic and supramammillary area calretinin-containing neurons of the female rat. Experimental Brain Research 1999, 128: 417-420. PMID: 10501815, DOI: 10.1007/s002210050863.
• Estrogen and microglia: A regulatory system that affects the brainMor G, Nilsen J, Horvath T, Bechmann I, Brown S, Garcia‐Segura L, Naftolin F. Estrogen and microglia: A regulatory system that affects the brain. Developmental Neurobiology 1999, 40: 484-496. PMID: 10453051, DOI: 10.1002/(sici)1097-4695(19990915)40:4<484::aid-neu6>3.0.co;2-c.
• O-085. Modulation of synapses during sexual differentiation of the brainNaftolin F, Horvath T, Garcia-Segura L. O-085. Modulation of synapses during sexual differentiation of the brain. Human Reproduction 1999, 14: 46-47. DOI: 10.1093/humrep/14.suppl_3.46-a.
• Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis.Pu S, Jain M, Horvath T, Diano S, Kalra P, Kalra S. Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis. Endocrinology 1999, 140: 933-40. PMID: 9927326, DOI: 10.1210/endo.140.2.6495.
• Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine RegulationsHorvath T, Diano S, van den Pol A. Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations. Journal Of Neuroscience 1999, 19: 1072-1087. PMID: 9920670, PMCID: PMC6782143, DOI: 10.1523/jneurosci.19-03-01072.1999.
• Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*Kalra S, Dube M, Pu S, Xu B, Horvath T, Kalra P. Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*. Endocrine Reviews 1999, 20: 68-100. PMID: 10047974, DOI: 10.1210/edrv.20.1.0357.
• Aromatase and Estrogen Receptor Immunoreactivity in the Coronary Arteries of Monkeys and Human SubjectsDiano S, Horvath T, Mor G, Register T, Adams M, Harada N, Naftolin F. Aromatase and Estrogen Receptor Immunoreactivity in the Coronary Arteries of Monkeys and Human Subjects. Menopause The Journal Of The North American Menopause Society 1999, 6: 21-28. PMID: 10100176, DOI: 10.1097/00042192-199906010-00006.
• Tracing of the entorhinal‐hippocampal pathway in vitroKluge A, Hailer N, Horvath T, Bechmann I, Nitsch R. Tracing of the entorhinal‐hippocampal pathway in vitro. Hippocampus 1998, 8: 57-68. PMID: 9519887, DOI: 10.1002/(sici)1098-1063(1998)8:1<57::aid-hipo6>3.0.co;2-4.
• Neuroendocrine Interactions between Galanin, Opioids, and Neuropeptide Y in the Control of Reproduction and Appetite aKALRA S, HORVATH T. Neuroendocrine Interactions between Galanin, Opioids, and Neuropeptide Y in the Control of Reproduction and Appetite a. Annals Of The New York Academy Of Sciences 1998, 863: 236-240. PMID: 9928174, DOI: 10.1111/j.1749-6632.1998.tb10698.x.
• Leptin receptors in estrogen receptor-containing neurons of the female rat hypothalamusDiano S, Kalra S, Sakamoto H, Horvath T. Leptin receptors in estrogen receptor-containing neurons of the female rat hypothalamus. Brain Research 1998, 812: 256-259. PMID: 9813356, DOI: 10.1016/s0006-8993(98)00936-6.
• Monosynaptic Pathway Between the Arcuate Nucleus Expressing Glial Type II Iodothyronine 5′‐Deiodinase mRNA and the Median Eminence‐Projective TRH Cells of the Rat Paraventricular NucleusDiano S, Naftolin F, Goglia F, Csernus V, Horvath T. Monosynaptic Pathway Between the Arcuate Nucleus Expressing Glial Type II Iodothyronine 5′‐Deiodinase mRNA and the Median Eminence‐Projective TRH Cells of the Rat Paraventricular Nucleus. Journal Of Neuroendocrinology 1998, 10: 731-742. PMID: 9792325, DOI: 10.1046/j.1365-2826.1998.00204.x.
• Leptin Receptor Immunoreactivity is Associated with the Golgi Apparatus of Hypothalamic Neurones and Glial CellsDiano S, Kalra S, Horvath T. Leptin Receptor Immunoreactivity is Associated with the Golgi Apparatus of Hypothalamic Neurones and Glial Cells. Journal Of Neuroendocrinology 1998, 10: 647-650. PMID: 9744481, DOI: 10.1046/j.1365-2826.1998.00261.x.
• Segregation of the intra- and extrahypothalamic neuropeptide Y and catecholaminergic inputs on paraventricular neurons, including those producing thyrotropin-releasing hormoneDiano S, Naftolin F, Goglia F, Horvath T. Segregation of the intra- and extrahypothalamic neuropeptide Y and catecholaminergic inputs on paraventricular neurons, including those producing thyrotropin-releasing hormone. Peptides 1998, 75: 117-126. PMID: 9802401, DOI: 10.1016/s0167-0115(98)00060-3.
• Gender-specific apposition between vasoactive intestinal peptide-containing axons and gonadotrophin-releasing hormone-producing neurons in the ratHorvath T, Cela V, van der Beek E. Gender-specific apposition between vasoactive intestinal peptide-containing axons and gonadotrophin-releasing hormone-producing neurons in the rat. Brain Research 1998, 795: 277-281. PMID: 9622650, DOI: 10.1016/s0006-8993(98)00208-x.
• Fasting-Induced Increase in Type II Iodothyronine Deiodinase Activity and Messenger Ribonucleic Acid Levels Is Not Reversed by Thyroxine in the Rat HypothalamusDiano S, Naftolin F, Goglia F, Horvath T. Fasting-Induced Increase in Type II Iodothyronine Deiodinase Activity and Messenger Ribonucleic Acid Levels Is Not Reversed by Thyroxine in the Rat Hypothalamus. Endocrinology 1998, 139: 2879-2884. PMID: 9607797, DOI: 10.1210/endo.139.6.6062.
• Kainate Glutamate Receptors (GluR5–7) in the Rat Arcuate Nucleus: Relationship to Tanycytes, Astrocytes, Neurons and Gonadal Steroid ReceptorsDiano S, Naftolin F, Horvath T. Kainate Glutamate Receptors (GluR5–7) in the Rat Arcuate Nucleus: Relationship to Tanycytes, Astrocytes, Neurons and Gonadal Steroid Receptors. Journal Of Neuroendocrinology 1998, 10: 239-247. PMID: 9630393, DOI: 10.1046/j.1365-2826.1998.00195.x.
• Hormonal control of brain cells: Opposite effects of estrogen vs estrogen-progestin replacement on GnRH cell membrane composition in female monkey brainsHORVATH T, PARK M, GARCIASEGURA L, NAFTOLIN F. Hormonal control of brain cells: Opposite effects of estrogen vs estrogen-progestin replacement on GnRH cell membrane composition in female monkey brains. Reproductive Sciences 1998, 5: 95a-95a. DOI: 10.1016/s1071-5576(97)86303-4.
• Evidence for a direct neuronal pathway from the suprachiasmatic nucleus to the gonadotropin‐releasing hormone system: Combined tracing and light and electron microscopic immunocytochemical studiesVan Der Beek E, Horvath T, Wiegant V, Van Den Hurk R, Buijs R. Evidence for a direct neuronal pathway from the suprachiasmatic nucleus to the gonadotropin‐releasing hormone system: Combined tracing and light and electron microscopic immunocytochemical studies. The Journal Of Comparative Neurology 1997, 384: 569-579. PMID: 9259490, DOI: 10.1002/(sici)1096-9861(19970811)384:4<569::aid-cne6>3.0.co;2-0.
• The Interactive Language of the Hypothalamus for the Gonadotropin Releasing Hormone (GNRH) SystemKalra S, Horvath T, Naftolin F, Xu B, Pu S, Kalra P. The Interactive Language of the Hypothalamus for the Gonadotropin Releasing Hormone (GNRH) System. Journal Of Neuroendocrinology 1997, 9: 569-576. PMID: 9283045, DOI: 10.1046/j.1365-2826.1997.00619.x.
• Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulationsHorvath T, Bechmann I, Naftolin F, Kalra S, Leranth C. Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Research 1997, 756: 283-286. PMID: 9187344, DOI: 10.1016/s0006-8993(97)00184-4.
• Aromatase in axonal processes of early postnatal hypothalamic and limbic areas including the cingulate cortexHorvath T, Roa-Pena L, Jakab R, Simpson E, Naftolin F. Aromatase in axonal processes of early postnatal hypothalamic and limbic areas including the cingulate cortex. The Journal Of Steroid Biochemistry And Molecular Biology 1997, 61: 349-357. PMID: 9365210, DOI: 10.1016/s0960-0760(97)80032-5.
• Suprachiasmatic efferents avoid phenestrated capillaries but innervate neuroendocrine cells, including those producing dopamine.Horvath T. Suprachiasmatic efferents avoid phenestrated capillaries but innervate neuroendocrine cells, including those producing dopamine. Endocrinology 1997, 138: 1312-20. PMID: 9048641, DOI: 10.1210/endo.138.3.4976.
• Gonadal steroids target AMPA glutamate receptor-containing neurons in the rat hypothalamus, septum and amygdala: a morphological and biochemical study.Diano S, Naftolin F, Horvath T. Gonadal steroids target AMPA glutamate receptor-containing neurons in the rat hypothalamus, septum and amygdala: a morphological and biochemical study. Endocrinology 1997, 138: 778-89. PMID: 9003015, DOI: 10.1210/endo.138.2.4937.
• S-6.Diano S, Mor G, Horvath T, Register T, Adams M, Naftolin F. S-6. Menopause The Journal Of The North American Menopause Society 1997, 4: 247. DOI: 10.1097/00042192-199704040-00045.
• Lack of Gonadotropin-Positive Feedback in the Male Rat Is Associated with Lack of Estrogen-Induced Synaptic Plasticity in the Arcuate NucleusHorvath T, Garcia-Segura L, Naftolin F. Lack of Gonadotropin-Positive Feedback in the Male Rat Is Associated with Lack of Estrogen-Induced Synaptic Plasticity in the Arcuate Nucleus. Neuroendocrinology 1997, 65: 136-140. PMID: 9067991, DOI: 10.1159/000127173.
• A45 The effects of estrogen on primate brain circuitryNaftolin F, Horvath T, Garcia-Segura L. A45 The effects of estrogen on primate brain circuitry. Maturitas 1996, 27: 14. DOI: 10.1016/s0378-5122(97)80881-x.
• Estradiol treatment increases the number of synapses targeting $beta;-endorphin cells.HORVATH T. Estradiol treatment increases the number of synapses targeting $beta;-endorphin cells. Reproductive Sciences 1996, 3: 162a. DOI: 10.1016/1071-5576(96)82655-4.
• Aromatase Immunoreactivity in Axon Terminals of the Vertebrate BrainNaftolin F, Horvath T, Jakab R, Leranth C, Harada N, Balthazart J. Aromatase Immunoreactivity in Axon Terminals of the Vertebrate Brain. Neuroendocrinology 1996, 63: 149-155. PMID: 9053779, DOI: 10.1159/000126951.
• Morphological Evidence for a Galanin‐Opiate Interaction in the Rat Mediobasal HypothalamusHorvath T, Kalra S, Naftolin F, Leranth C. Morphological Evidence for a Galanin‐Opiate Interaction in the Rat Mediobasal Hypothalamus. Journal Of Neuroendocrinology 1995, 7: 579-588. PMID: 8704731, DOI: 10.1111/j.1365-2826.1995.tb00795.x.
• Aromatase immunoreactive neurons and neuronal processes in the hypothalamus of human (IR-ARO) fetuses and adult subjectsHORVATH T. Aromatase immunoreactive neurons and neuronal processes in the hypothalamus of human (IR-ARO) fetuses and adult subjects. Reproductive Sciences 1995, 2: 163. DOI: 10.1016/1071-5576(95)94155-n.
• Estrogen-induced hypothalamic synaptic plasticity and the regulation of gonadotrophinsHorvath T, Leedom L, Lewis C, Garcia-Segura L, Naftolin F. Estrogen-induced hypothalamic synaptic plasticity and the regulation of gonadotrophins. Current Opinion In Endocrinology Diabetes And Obesity 1995, 2: 186. DOI: 10.1097/00060793-199504000-00018.
• Galanin neurons exhibit estrogen receptor immunoreactivity in the female rat mediobasal hypothalamusHorvath T, Leranth C, Kalra S, Naftolin F. Galanin neurons exhibit estrogen receptor immunoreactivity in the female rat mediobasal hypothalamus. Brain Research 1995, 675: 321-324. PMID: 7540929, DOI: 10.1016/0006-8993(94)01374-q.
• Distribution of Estrogen Receptor-Immunoreactive Cells in Monkey Hypothalamus: Relationship to Neurones Containing Luteinizing Hormone-Releasing Hormone and Tyrosine HydroxylaseHerbison A, Horvath T, Naftolin F, Leranth C. Distribution of Estrogen Receptor-Immunoreactive Cells in Monkey Hypothalamus: Relationship to Neurones Containing Luteinizing Hormone-Releasing Hormone and Tyrosine Hydroxylase. Neuroendocrinology 1995, 61: 1-10. PMID: 7731492, DOI: 10.1159/000126810.
• Naloxone reduces the feeding evoked by intracerebroventricular galanin injectionDube M, Horvath T, Leranth C, Kalra P, Kalra S. Naloxone reduces the feeding evoked by intracerebroventricular galanin injection. Physiology & Behavior 1994, 56: 811-813. PMID: 7528433, DOI: 10.1016/0031-9384(94)90247-x.
• 25 Electron Microscopic Double and Triple Labeling Immunocytochemistry in Elucidation of Synaptological Interactions between Ovarian Steroid-Sensitive Neurons and CircuitsLeranth C, Naftolin F, Shanabrough M, Horvath T. 25 Electron Microscopic Double and Triple Labeling Immunocytochemistry in Elucidation of Synaptological Interactions between Ovarian Steroid-Sensitive Neurons and Circuits. 1994, 22: 403-434. DOI: 10.1016/b978-0-12-185292-4.50031-0.
• Luteinizing Hormone‐Releasing Hormone and Gamma‐Aminobutyric Acid Neurons in the Medial Preoptic Area are Synaptic Targets of Dopamine Axons Originating in Anterior Periventricular AreasHorvath T, Naftolin F, Leranth C. Luteinizing Hormone‐Releasing Hormone and Gamma‐Aminobutyric Acid Neurons in the Medial Preoptic Area are Synaptic Targets of Dopamine Axons Originating in Anterior Periventricular Areas. Journal Of Neuroendocrinology 1993, 5: 71-79. PMID: 8097941, DOI: 10.1111/j.1365-2826.1993.tb00365.x.