Zhongwu Liu, MD
Research Scientist
Research & Publications
Biography
News
Research Summary
Cellular Electrophysiology and Neuroscience
Coauthors
Selected Publications
- TET3 epigenetically controls feeding and stress response behaviors via AGRP neuronsXie D, Stutz B, Li F, Chen F, Lv H, Sestan-Pesa M, Catarino J, Gu J, Zhao H, Stoddard CE, Carmichael GG, Shanabrough M, Taylor HS, Liu ZW, Gao XB, Horvath TL, Huang Y. TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons. Journal Of Clinical Investigation 2022, 132: e162365. PMID: 36189793, PMCID: PMC9525119, DOI: 10.1172/jci162365.
- LINE-1 activation in the cerebellum drives ataxiaTakahashi T, Stoiljkovic M, Song E, Gao XB, Yasumoto Y, Kudo E, Carvalho F, Kong Y, Park A, Shanabrough M, Szigeti-Buck K, Liu ZW, Kristant A, Zhang Y, Sulkowski P, Glazer PM, Kaczmarek LK, Horvath TL, Iwasaki A. LINE-1 activation in the cerebellum drives ataxia. Neuron 2022, 110: 3278-3287.e8. PMID: 36070749, PMCID: PMC9588660, DOI: 10.1016/j.neuron.2022.08.011.
- Ventromedial hypothalamic OGT drives adipose tissue lipolysis and curbs obesityWang Q, Zhang B, Stutz B, Liu ZW, Horvath TL, Yang X. Ventromedial hypothalamic OGT drives adipose tissue lipolysis and curbs obesity. Science Advances 2022, 8: eabn8092. PMID: 36044565, PMCID: PMC9432828, DOI: 10.1126/sciadv.abn8092.
- AgRP neurons control structure and function of the medial prefrontal cortexStutz B, Waterson MJ, Šestan-Peša M, Dietrich MO, Škarica M, Sestan N, Racz B, Magyar A, Sotonyi P, Liu ZW, Gao XB, Matyas F, Stoiljkovic M, Horvath TL. AgRP neurons control structure and function of the medial prefrontal cortex. Molecular Psychiatry 2022, 27: 3951-3960. PMID: 35906488, PMCID: PMC9891653, DOI: 10.1038/s41380-022-01691-8.
- Correction: Drp1 is required for AgRP neuronal activity and feedingJin S, Yoon NA, Liu ZW, Song JE, Horvath TL, Kim JD, Diano S. Correction: Drp1 is required for AgRP neuronal activity and feeding. ELife 2022, 11: e80570. PMID: 35763333, PMCID: PMC9239674, DOI: 10.7554/elife.80570.
- AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipidsEndle H, Horta G, Stutz B, Muthuraman M, Tegeder I, Schreiber Y, Snodgrass IF, Gurke R, Liu ZW, Sestan-Pesa M, Radyushkin K, Streu N, Fan W, Baumgart J, Li Y, Kloss F, Groppa S, Opel N, Dannlowski U, Grabe HJ, Zipp F, Rácz B, Horvath TL, Nitsch R, Vogt J. AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids. Nature Metabolism 2022, 4: 683-692. PMID: 35760867, PMCID: PMC9940119, DOI: 10.1038/s42255-022-00589-7.
- Astrocytic lipid metabolism determines susceptibility to diet-induced obesityVarela L, Kim JG, Fernández-Tussy P, Aryal B, Liu ZW, Fernández-Hernando C, Horvath TL. Astrocytic lipid metabolism determines susceptibility to diet-induced obesity. Science Advances 2021, 7: eabj2814. PMID: 34890239, DOI: 10.1126/sciadv.abj2814.
- Drp1 is required for AgRP neuronal activity and feedingJin S, Yoon NA, Liu ZW, Song JE, Horvath TL, Kim JD, Diano S. Drp1 is required for AgRP neuronal activity and feeding. ELife 2021, 10: e64351. PMID: 33689681, PMCID: PMC7946429, DOI: 10.7554/elife.64351.
- MC4R Signaling in Dorsal Raphe Nucleus Controls Feeding, Anxiety, and DepressionBruschetta G, Jin S, Liu ZW, Kim JD, Diano S. MC4R Signaling in Dorsal Raphe Nucleus Controls Feeding, Anxiety, and Depression. Cell Reports 2020, 33: 108267. PMID: 33053350, DOI: 10.1016/j.celrep.2020.108267.
- Impaired hypocretin/orexin system alters responses to salient stimuli in obese male miceTan Y, Hang F, Liu ZW, Stoiljkovic M, Wu M, Tu Y, Han W, Lee AM, Kelley C, Hajos M, Lu L, de Lecea L, de Araujo I, Picciotto M, Horvath TL, Gao XB. Impaired hypocretin/orexin system alters responses to salient stimuli in obese male mice. Journal Of Clinical Investigation 2020, 130: 4985-4998. PMID: 32516139, PMCID: PMC7456212, DOI: 10.1172/jci130889.
- Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activityStutz B, Nasrallah C, Nigro M, Curry D, Liu ZW, Gao XB, Elsworth JD, Mintz L, Horvath TL. Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity. Molecular Metabolism 2019, 24: 120-138. PMID: 30833218, PMCID: PMC6531791, DOI: 10.1016/j.molmet.2019.02.005.
- The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain DevelopmentTebbenkamp ATN, Varela L, Choi J, Paredes MI, Giani AM, Song JE, Sestan-Pesa M, Franjic D, Sousa AMM, Liu ZW, Li M, Bichsel C, Koch M, Szigeti-Buck K, Liu F, Li Z, Kawasawa YI, Paspalas CD, Mineur YS, Prontera P, Merla G, Picciotto MR, Arnsten AFT, Horvath TL, Sestan N. The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development. Cell 2018, 175: 1088-1104.e23. PMID: 30318146, PMCID: PMC6459420, DOI: 10.1016/j.cell.2018.09.014.
- A Neural Circuit for Gut-Induced RewardHan W, Tellez LA, Perkins MH, Perez IO, Qu T, Ferreira J, Ferreira TL, Quinn D, Liu ZW, Gao XB, Kaelberer MM, Bohórquez DV, Shammah-Lagnado SJ, de Lartigue G, de Araujo IE. A Neural Circuit for Gut-Induced Reward. Cell 2018, 175: 887-888. PMID: 30340046, DOI: 10.1016/j.cell.2018.10.018.
- A Neural Circuit for Gut-Induced RewardHan W, Tellez LA, Perkins MH, Perez IO, Qu T, Ferreira J, Ferreira TL, Quinn D, Liu ZW, Gao XB, Kaelberer MM, Bohórquez DV, Shammah-Lagnado SJ, de Lartigue G, de Araujo IE. A Neural Circuit for Gut-Induced Reward. Cell 2018, 175: 665-678.e23. PMID: 30245012, PMCID: PMC6195474, DOI: 10.1016/j.cell.2018.08.049.
- Endometriosis alters brain electrophysiology, gene expression and increases pain sensitization, anxiety, and depression in female mice†Li T, Mamillapalli R, Ding S, Chang H, Liu ZW, Gao XB, Taylor HS. Endometriosis alters brain electrophysiology, gene expression and increases pain sensitization, anxiety, and depression in female mice†. Biology Of Reproduction 2018, 99: 349-359. PMID: 29425272, PMCID: PMC6692844, DOI: 10.1093/biolre/ioy035.
- Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neuronsSuyama S, Ralevski A, Liu ZW, Dietrich MO, Yada T, Simonds SE, Cowley MA, Gao XB, Diano S, Horvath TL. Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons. ELife 2017, 6: e25755. PMID: 28762946, PMCID: PMC5538821, DOI: 10.7554/elife.25755.
- DRP1 Suppresses Leptin and Glucose Sensing of POMC NeuronsSantoro A, Campolo M, Liu C, Sesaki H, Meli R, Liu ZW, Kim JD, Diano S. DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons. Cell Metabolism 2017, 25: 647-660. PMID: 28190775, PMCID: PMC5366041, DOI: 10.1016/j.cmet.2017.01.003.
- UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose ResponsivenessToda C, Kim JD, Impellizzeri D, Cuzzocrea S, Liu ZW, Diano S. UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness. Cell 2016, 164: 872-883. PMID: 26919426, PMCID: PMC4770556, DOI: 10.1016/j.cell.2016.02.010.
- O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White FatRuan HB, Dietrich MO, Liu ZW, Zimmer MR, Li MD, Singh JP, Zhang K, Yin R, Wu J, Horvath TL, Yang X. O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat. Cell 2014, 159: 306-317. PMID: 25303527, PMCID: PMC4509746, DOI: 10.1016/j.cell.2014.09.010.
- Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feedingKim JG, Suyama S, Koch M, Jin S, Argente-Arizon P, Argente J, Liu ZW, Zimmer MR, Jeong JK, Szigeti-Buck K, Gao Y, Garcia-Caceres C, Yi CX, Salmaso N, Vaccarino FM, Chowen J, Diano S, Dietrich MO, Tschöp MH, Horvath TL. Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nature Neuroscience 2014, 17: 908-910. PMID: 24880214, PMCID: PMC4113214, DOI: 10.1038/nn.3725.
- Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced ObesityDietrich MO, Liu ZW, Horvath TL. Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity. Cell 2013, 155: 188-199. PMID: 24074868, PMCID: PMC4142434, DOI: 10.1016/j.cell.2013.09.004.
- Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugarDomingos AI, Sordillo A, Dietrich MO, Liu ZW, Tellez LA, Vaynshteyn J, Ferreira JG, Ekstrand MI, Horvath TL, de Araujo IE, Friedman JM. Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar. ELife 2013, 2: e01462. PMID: 24381247, PMCID: PMC3875383, DOI: 10.7554/elife.01462.
- Leptin regulates glutamate and glucose transporters in hypothalamic astrocytesFuente-Martín E, García-Cáceres C, Granado M, de Ceballos ML, Sánchez-Garrido MÁ, Sarman B, Liu ZW, Dietrich MO, Tena-Sempere M, Argente-Arizón P, Díaz F, Argente J, Horvath TL, Chowen JA. Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes. Journal Of Clinical Investigation 2012, 122: 3900-3913. PMID: 23064363, PMCID: PMC3484452, DOI: 10.1172/jci64102.
- Prolyl Endopeptidase-Deficient Mice Have Reduced Synaptic Spine Density in the CA1 Region of the Hippocampus, Impaired LTP, and Spatial Learning and MemoryD'Agostino G, Kim JD, Liu ZW, Jeong JK, Suyama S, Calignano A, Gao XB, Schwartz M, Diano S. Prolyl Endopeptidase-Deficient Mice Have Reduced Synaptic Spine Density in the CA1 Region of the Hippocampus, Impaired LTP, and Spatial Learning and Memory. Cerebral Cortex 2012, 23: 2007-2014. PMID: 22767632, PMCID: PMC3841400, DOI: 10.1093/cercor/bhs199.
- AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviorsDietrich MO, Bober J, Ferreira JG, Tellez LA, Mineur YS, Souza DO, Gao XB, Picciotto MR, Araújo I, Liu ZW, Horvath TL. AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors. Nature Neuroscience 2012, 15: 1108-1110. PMID: 22729177, PMCID: PMC3411867, DOI: 10.1038/nn.3147.
- Erratum: Corrigendum: Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesityDiano S, Liu Z, Jeong J, Dietrich M, Ruan H, Kim E, Suyama S, Kelly K, Gyengesi E, Arbiser J, Belsham D, Sarruf D, Schwartz M, Bennett A, Shanabrough M, Mobbs C, Yang X, Gao X, Horvath T. Erratum: Corrigendum: Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nature Medicine 2011, 17: 1320-1320. DOI: 10.1038/nm1011-1320a.
- Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesityDiano S, Liu ZW, Jeong JK, Dietrich MO, Ruan HB, Kim E, Suyama S, Kelly K, Gyengesi E, Arbiser JL, Belsham DD, Sarruf DA, Schwartz MW, Bennett AM, Shanabrough M, Mobbs CV, Yang X, Gao XB, Horvath TL. Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nature Medicine 2011, 17: 1121-1127. PMID: 21873987, PMCID: PMC3388795, DOI: 10.1038/nm.2421.
- Direct Evidence for Wake-Related Increases and Sleep-Related Decreases in Synaptic Strength in Rodent CortexLiu ZW, Faraguna U, Cirelli C, Tononi G, Gao XB. Direct Evidence for Wake-Related Increases and Sleep-Related Decreases in Synaptic Strength in Rodent Cortex. Journal Of Neuroscience 2010, 30: 8671-8675. PMID: 20573912, PMCID: PMC2903226, DOI: 10.1523/jneurosci.1409-10.2010.
- A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy ExpenditureYadav VK, Oury F, Suda N, Liu ZW, Gao XB, Confavreux C, Klemenhagen KC, Tanaka KF, Gingrich JA, Guo XE, Tecott LH, Mann JJ, Hen R, Horvath TL, Karsenty G. A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure. Cell 2009, 138: 976-989. PMID: 19737523, PMCID: PMC2768582, DOI: 10.1016/j.cell.2009.06.051.
- Prolylcarboxypeptidase regulates food intake by inactivating α-MSH in rodentsWallingford N, Perroud B, Gao Q, Coppola A, Gyengesi E, Liu ZW, Gao XB, Diament A, Haus KA, Shariat-Madar Z, Mahdi F, Wardlaw SL, Schmaier AH, Warden CH, Diano S. Prolylcarboxypeptidase regulates food intake by inactivating α-MSH in rodents. Journal Of Clinical Investigation 2009, 119: 2291-2303. PMID: 19620781, PMCID: PMC2719925, DOI: 10.1172/jci37209.
- Erratum: UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicalsAndrews Z, Liu Z, Walllingford N, Erion D, Borok E, Friedman J, Tschöp M, Shanabrough M, Cline G, Shulman G, Coppola A, Gao X, Horvath T, Diano S. Erratum: UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals. Nature 2009, 459: 736-736. DOI: 10.1038/nature08132.
- UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicalsAndrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM, Tschöp MH, Shanabrough M, Cline G, Shulman GI, Coppola A, Gao XB, Horvath TL, Diano S. UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals. Nature 2008, 454: 846-851. PMID: 18668043, PMCID: PMC4101536, DOI: 10.1038/nature07181.
- Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neuronsRao Y, Liu ZW, Borok E, Rabenstein RL, Shanabrough M, Lu M, Picciotto MR, Horvath TL, Gao XB. Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons. Journal Of Clinical Investigation 2007, 117: 4022-4033. PMID: 18060037, PMCID: PMC2104495, DOI: 10.1172/jci32829.
- Adenosine Inhibits Activity of Hypocretin/Orexin Neurons by the A1 Receptor in the Lateral Hypothalamus: A Possible Sleep-Promoting EffectLiu ZW, Gao XB. Adenosine Inhibits Activity of Hypocretin/Orexin Neurons by the A1 Receptor in the Lateral Hypothalamus: A Possible Sleep-Promoting Effect. Journal Of Neurophysiology 2006, 97: 837-848. PMID: 17093123, PMCID: PMC1783688, DOI: 10.1152/jn.00873.2006.
- Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetiteAbizaid A, Liu ZW, Andrews ZB, Shanabrough M, Borok E, Elsworth JD, Roth RH, Sleeman MW, Picciotto MR, Tschöp MH, Gao XB, Horvath TL. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. Journal Of Clinical Investigation 2006, 116: 3229-3239. PMID: 17060947, PMCID: PMC1618869, DOI: 10.1172/jci29867.
- Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates FeedingHommel JD, Trinko R, Sears RM, Georgescu D, Liu ZW, Gao XB, Thurmon JJ, Marinelli M, DiLeone RJ. Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding. Neuron 2006, 51: 801-810. PMID: 16982424, DOI: 10.1016/j.neuron.2006.08.023.
- [Activation of Ca(2+)-activated K+ channels by oxyphenamone in rabbit mesenteric vascular smooth muscle cells].Li AL, Liu ZW, Zhu LX, Zhang DC, Ye YX. [Activation of Ca(2+)-activated K+ channels by oxyphenamone in rabbit mesenteric vascular smooth muscle cells]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica 2004, 39: 101-4. PMID: 15127615.
- [Long term learning memory and long term potential of hippocampus in cerebral injury of ischemic hypoxic neonatal rats].Xie JJ, Chen BF, Liu ZW, Chang Y, Yang Y, Li T, Pan T, Mai G. [Long term learning memory and long term potential of hippocampus in cerebral injury of ischemic hypoxic neonatal rats]. Zhonghua Er Ke Za Zhi. Chinese Journal Of Pediatrics 2003, 41: 50-1. PMID: 14761331.
- Characterization of a hyperpolarization-activated inward current in cultured pacemaker cells from the sinoatrial node.Liu ZW, Zou AR, Demir SS, Clark JW, Nathan RD. Characterization of a hyperpolarization-activated inward current in cultured pacemaker cells from the sinoatrial node. Journal Of Molecular And Cellular Cardiology 1996, 28: 2523-35. PMID: 9004168, DOI: 10.1006/jmcc.1996.0244.
- Phorbol ester alters rat hippocampal neuronal response to hypoxia.Liu ZW, Fowler JC. Phorbol ester alters rat hippocampal neuronal response to hypoxia. Neuroreport 1995, 6: 2069-72. PMID: 8580442, DOI: 10.1097/00001756-199510010-00027.