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Heather Allore, PhD

Professor of Medicine (Geriatrics) and of Biostatistics; Leader, Data Management and Statistics Core, Yale Alzheimer's Disease Research Center, Internal Medicine; Co-director of the Biostatistics and Bioinformatics Core of the Yale Transdisciplinary Collaborative Center for Precision Medicine focused on Health Disparities, Yale Transdisciplinary Collaborative Center for Precision Medicine ; Associate Director of Gerontologic Biostatistical Methods, Internal Medicine: Geriatrics; Senior Biostatistician and Epidemiologist, Internal Medicine: Rheumatology; Co-Director of Biostatistical Core, Internal Medicine: Geriatrics

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Heather Allore, PhD

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Research Summary

Dr. Allore's research is focused on issues related to the design and analysis of studies of multi-component interventions and the design and analysis of observational studies of multifactorial geriatric health conditions. Other areas of her applied research include developing strategies for handling missing data that frequently occurs in studies of older persons, applying extended Cox models for state transitions in geriatrics, such as frailty and disability that consist of multiple discrete states in which both onset and recovery are possible, and determining the mechanisms of action of an effective multi-component intervention. She has collaborated on several projects in immunology and is introducing new analytic methods to account for correlations among elements of the innate immune system. She developed a subdiscipline of biostatistics within the American Statistical Association that focuses on training and methodological development in Aging Research called "Gerontologic Biostatistics." This discipline trains biostatisticians for conducting collaborative clinical research with geriatricians and gerontologists in elderly populations and provide the basis for the development new statistical methodology. She served on the NIH Aging Systems and Geriatrics study section, VA Human Rights Committee, and CDC Special Emphasis study section. She has served as a reviewer and editorial board member for a variety of medical journals.

Specialized Terms: State transition models; Experimental design; Longitudinal methods; Missing data Methods; Marginal structural models; Latent class models; Trajectory models; Dynamic stochastic models; Joint models

Extensive Research Description

Dr. Allore's current research includes analytic methods for Alzheimer's and related dementias, polypharmacy, functional and mobility disability in the older adults, differences in immune system function of between young and older persons, and multiple comorbid conditions.

She is also developing a subdiscipline of biostatistics within the American Statistical Association that focuses on training and methodological development in geriatrics called “gerontologic biostatistics.” This discipline trains biostatisticians for conducting collaborative clinical research with geriatricians and gerontologists in elderly populations and provide the basis for the development new statistical methodology.

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Research Interests

Aging; Geriatrics; Statistics as Topic; Frail Elderly; Mathematical Concepts; Biostatistics

Public Health Interests

Aging; Epidemiology Methods

Selected Publications

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