Susan Compton, PhD
Senior Research Scientist in Comparative Medicine; Director, Molecular and Serological Diagnostics, Comparative Medicine
Research & Publications
Biography
Research Summary
- Understanding the pathogenesis and epizootiology of rodent pathogens
- Development and validation of new diagnostic methods to detect rodent pathogens (astrovirus, coronavirus, parvovirus, norovirus, fur mites, pinworms)
Specialized Terms: Pathogenesis of rodent viral infections; Diagnostic Virology; Communicable Diseases; Coronavirus; Disease Control; Disease Model; Fur Mites; Gastrointestinal Infection; Host Organism Interaction; Immunoassay; Infectious Diseases/Agents; Intestinal Mucosa; Laboratory Mouse; Laboratory Rat; Norovirus; Parvovirus; Pathogenesis; Pinworms; PCR; Rat Coronavirus; Respiratory Diseases; RT-RCR; Serology; Sialodacryoadenitis Virus; Virology; Virulence; Virus Infection Mechanism; Virus Protein; Virus Receptor;
Coauthors
Research Interests
Bacterial Infections and Mycoses; DNA Virus Infections; Ectoparasitic Infestations; RNA Virus Infections; Rodent Diseases; Virus Diseases; Zoonoses; Coronavirus; Parvovirus; Norovirus; Organisms; Viral Zoonoses
Public Health Interests
Cross-Species Transmission; Disease Transmission; Infectious Diseases; Viruses; Zoonotic Diseases
Selected Publications
- The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expressionWei J, Alfajaro M, Cai W, Graziano V, Strine M, Filler R, Biering S, Sarnik S, Patel S, Menasche B, Compton S, Konermann S, Hsu P, Orchard R, Yan Q, Wilen C. The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression. PLOS Pathogens 2023, 19: e1011351. PMID: 37410700, PMCID: PMC10325096, DOI: 10.1371/journal.ppat.1011351.
- Modeling pandemic to endemic patterns of SARS-CoV-2 transmission using parameters estimated from animal model dataMullin S, Wyk BV, Asher JL, Compton SR, Allore HG, Zeiss CJ. Modeling pandemic to endemic patterns of SARS-CoV-2 transmission using parameters estimated from animal model data. PNAS Nexus 2022, 1: pgac096. PMID: 35799833, PMCID: PMC9254158, DOI: 10.1093/pnasnexus/pgac096.
- Modeling SARS-CoV-2 propagation using rat coronavirus-associated shedding and transmissionZeiss CJ, Asher JL, Wyk B, Allore HG, Compton SR. Modeling SARS-CoV-2 propagation using rat coronavirus-associated shedding and transmission. PLOS ONE 2021, 16: e0260038. PMID: 34813610, PMCID: PMC8610237, DOI: 10.1371/journal.pone.0260038.
- Overview of Coronaviruses in Veterinary Medicine.Compton SR. Overview of Coronaviruses in Veterinary Medicine. Comparative Medicine 2021, 71: 333-341. PMID: 34412731, PMCID: PMC8594256, DOI: 10.30802/aalas-cm-21-000007.
- Animal Models of COVID-19. I. Comparative Virology and Disease PathogenesisZeiss CJ, Compton S, Veenhuis RT. Animal Models of COVID-19. I. Comparative Virology and Disease Pathogenesis. ILAR Journal 2021, 62: ilab007-. PMID: 33836527, PMCID: PMC8083356, DOI: 10.1093/ilar/ilab007.
- Cutaneous and Pulmonary Mucormycosis in Rag1- and Il2rg-deficient Rats.Sarfaty AE, Compton SR, Smith PC, Zeiss CJ. Cutaneous and Pulmonary Mucormycosis in Rag1- and Il2rg-deficient Rats. Comparative Medicine 2020, 70: 390-395. PMID: 32736665, PMCID: PMC7446636, DOI: 10.30802/aalas-cm-20-000015.
- PCR and RT-PCR in the Diagnosis of Laboratory Animal Infections and in Health Monitoring.Compton SR. PCR and RT-PCR in the Diagnosis of Laboratory Animal Infections and in Health Monitoring. Journal Of The American Association For Laboratory Animal Science 2020, 59: 458-468. PMID: 32580820, PMCID: PMC7479767, DOI: 10.30802/aalas-jaalas-20-000008.
- Transverse myelitis following measles vaccination in a rhesus macaque (Macaca mulatta)Sarfaty AE, Fulbright RK, Compton SR, Asher JL, Zeiss CJ. Transverse myelitis following measles vaccination in a rhesus macaque (Macaca mulatta). Journal Of Medical Primatology 2019, 49: 103-106. PMID: 31789460, DOI: 10.1111/jmp.12453.
- Chapter 13 Viral DiseaseMacy J, Compton S. Chapter 13 Viral Disease. 2019, 541-568. PMCID: PMC7153344, DOI: 10.1016/b978-0-12-814338-4.00013-1.
- Lack of Effect of Murine Astrovirus Infection on Dextran Sulfate-induced Colitis in NLRP3-deficient Mice.Compton SR, Booth CJ, Macy JD. Lack of Effect of Murine Astrovirus Infection on Dextran Sulfate-induced Colitis in NLRP3-deficient Mice. Comparative Medicine 2017, 67: 400-406. PMID: 28935001, PMCID: PMC5621567.
- Murine Astrovirus Infection and Transmission in Neonatal CD1 Mice.Compton SR, Booth CJ, Macy JD. Murine Astrovirus Infection and Transmission in Neonatal CD1 Mice. Journal Of The American Association For Laboratory Animal Science 2017, 56: 402-411. PMID: 28724490, PMCID: PMC5517330.
- Effect of Cage-Wash Temperature on the Removal of Infectious Agents from Caging and the Detection of Infectious Agents on the Filters of Animal Bedding-Disposal Cabinets by PCR Analysis.Compton SR, Macy JD. Effect of Cage-Wash Temperature on the Removal of Infectious Agents from Caging and the Detection of Infectious Agents on the Filters of Animal Bedding-Disposal Cabinets by PCR Analysis. Journal Of The American Association For Laboratory Animal Science 2015, 54: 745-55. PMID: 26632784, PMCID: PMC4671790.
- Immune Regulation and Oxidative Stress Reduction by Preimplantation Factor following Syngeneic or Allogeneic Bone Marrow TransplantationShainer R, Azar Y, Almogi-Hazan O, Bringer R, Compton S, Paidas M, Barnea E, Or R. Immune Regulation and Oxidative Stress Reduction by Preimplantation Factor following Syngeneic or Allogeneic Bone Marrow Transplantation. Conference Papers In Medicine 2013, 2013: 1-8. DOI: 10.1155/2013/718031.
- Effect of immunodeficiency on MPV shedding and transmission.Macy JD, Paturzo FX, Compton SR. Effect of immunodeficiency on MPV shedding and transmission. Journal Of The American Association For Laboratory Animal Science 2013, 52: 467-74. PMID: 23849445, PMCID: PMC3725932.
- Age-associated variability in susceptibility of Swiss Webster mice to MPV and other excluded murine pathogens.Grove KA, Smith PC, Booth CJ, Compton SR. Age-associated variability in susceptibility of Swiss Webster mice to MPV and other excluded murine pathogens. Journal Of The American Association For Laboratory Animal Science 2012, 51: 789-96. PMID: 23294885, PMCID: PMC3508183.
- Transmission of mouse parvovirus by fomites.Compton SR, Paturzo FX, Smith PC, Macy JD. Transmission of mouse parvovirus by fomites. Journal Of The American Association For Laboratory Animal Science 2012, 51: 775-80. PMID: 23294883, PMCID: PMC3508181.
- Transmission of mouse parvovirus to neonatal mice.Compton SR, Paturzo FX, Macy JD. Transmission of mouse parvovirus to neonatal mice. Journal Of The American Association For Laboratory Animal Science 2012, 51: 797-802. PMID: 23294886, PMCID: PMC3508184.
- Interactions of Enterotropic Mouse Hepatitis Viruses with Bgp2 Receptor ProteinsCompton S. Interactions of Enterotropic Mouse Hepatitis Viruses with Bgp2 Receptor Proteins. 1998, 440: 25-31. PMID: 9782261, DOI: 10.1007/978-1-4615-5331-1_4.
- Growth characteristics and protein profiles of prototype and wild-type rat coronavirus isolates grown in a cloned subline of mouse fibroblasts (L2p.176 cells)Gaertner D, Compton S, Winograd D, Smith A. Growth characteristics and protein profiles of prototype and wild-type rat coronavirus isolates grown in a cloned subline of mouse fibroblasts (L2p.176 cells). Virus Research 1996, 41: 55-68. PMID: 8725102, PMCID: PMC7134090, DOI: 10.1016/0168-1702(95)01274-5.
- Molecular characterization of the S proteins of two enterotropic murine coronavirus strainsKunita S, Zhang L, Homberger F, Compton S. Molecular characterization of the S proteins of two enterotropic murine coronavirus strains. Virus Research 1995, 35: 277-289. PMID: 7785316, PMCID: PMC7134003, DOI: 10.1016/0168-1702(94)00089-u.
- Characterization of the S Protein of Enterotropic Murine Coronavirus Strain-YCompton S, Kunita S. Characterization of the S Protein of Enterotropic Murine Coronavirus Strain-Y. 1995, 380: 23-28. PMID: 8830485, DOI: 10.1007/978-1-4615-1899-0_3.
- Multiple Receptor-Dependent Steps Determine the Species Specificity of HCV-229E InfectionLevis R, Cardellichio C, Scanga C, Compton S, Holmes K. Multiple Receptor-Dependent Steps Determine the Species Specificity of HCV-229E Infection. 1995, 380: 337-343. PMID: 8830504, DOI: 10.1007/978-1-4615-1899-0_55.
- Coronavirus ReceptorsHolmes K, Compton S. Coronavirus Receptors. 1995, 55-71. DOI: 10.1007/978-1-4899-1531-3_4.
- Enterotropic Strains of Mouse Coronavirus Differ in Their Use of Murine Carcinoembryonic Antigen-Related Glycoprotein ReceptorsCompton S. Enterotropic Strains of Mouse Coronavirus Differ in Their Use of Murine Carcinoembryonic Antigen-Related Glycoprotein Receptors. Virology 1994, 203: 197-201. PMID: 8030279, PMCID: PMC7131022, DOI: 10.1006/viro.1994.1475.
- Is the 110K Glycoprotein the Only Receptor for MHV and Does Its Expression Determine Species Specificity?Holmes K, Williams R, Cardellichio C, Compton S, Stephensen C, Snyder S, Frana M, Jiang G, Smith A, Knobler R. Is the 110K Glycoprotein the Only Receptor for MHV and Does Its Expression Determine Species Specificity? 1990, 276: 37-44. PMID: 1966425, DOI: 10.1007/978-1-4684-5823-7_6.