D. S. Fahmeed Hyder, PhD
Cards
About
Titles
Professor of Radiology and Biomedical Imaging and of Biomedical Engineering
Technical Director, Magnetic Resonance Research Center (mrrc.yale.edu); Program Director, Core Center for Quantitative Neuroscience with Magnetic Resonance (qnmr.yale.edu)Biography
Dr. Hyder is Professor of Radiology & Biomedical Imaging and Professor of Biomedical Engineering, where he is a founding faculty member. He is Head of MRS Group of the MRRC and Director of QNMR Research Program. He studied physical chemistry at Wabash College (BA 1990) and biophysical chemistry at Yale University (PhD 1995).
Dr. Hyder studies brain energy metabolism. His lab develops magnetic resonance (MR) based imaging methods to study brain physiology and chemistry, revealing how neuronal-glial cells fuel their function and (re)growth. He posits that mapping metabolic dysfunction (e.g., energetics for cellular function vs. cellular proliferation) can indicate early biomarkers of brain disorders and diseases. To map brain’s physiology and chemistry with MR-based imaging and spectroscopic advances and targeted delivery and monitoring of treatments, his laboratory conducts multidisciplinary functional and molecular imaging of neurodegeneration and neuro-oncology, requiring expertise in physics to chemistry to engineering to cancer biology to neuroscience. His contributions include development of high-resolution fMRI in preclinical models, calibrated fMRI for quantitative imaging of neuronal activity, and molecular imaging methods for pH and temperature mapping and other physiological parameters that are relevant in cancer diagnosis and treatment.
Dr. Hyder has written and edited books on functional brain imaging and holds several patents on molecular imaging of cancer. His research work has produced over 240 papers with as many invited presentations, amassing over 20K citations. He has had continuous NIH support for 25 years, spanning across interests from 7 different NIH institutes. He has renewed grants from different funding agencies and has received several early career awards from. He sits on editorial boards of several scientific journals, and he reviews for many scientific journals spanning several disciplines. He serves on advisory panels of several funding agencies.
Dr. Hyder holds many honors, including the Melvin H. Knisely Award from the International Society on Oxygen Transport to Tissue, the Niels Lassen Award from the International Society for Cerebral Blood Flow and Metabolism, and the Lundbeck Foundation Visiting Professorship at the University of Copenhagen. He has fellowships in American Institute for Medical and Biological Engineering, Academy of Radiology & Biomedical Imaging Research, and Sigma Xi the Scientific Research Honor Society. Recently, he was appointed Head of Trumbull College at Yale University and received a General Assembly Official Citation from the State of Connecticut.
Appointments
Radiology & Biomedical Imaging
ProfessorFully Joint
Other Departments & Organizations
- Bioimaging Sciences
- Brain Energy Atlas Project
- Dean's Workshops
- Diabetes Research Center
- Interdepartmental Neuroscience Program
- Magnetic Resonance Research Center
- Magnetic Resonance Spectroscopy
- Neural Disorders
- Neuroscience Track
- Purple College Affiliates
- Quantitative Neuroscience with Magnetic Resonance
- Radiobiology and Genome Integrity
- Radiology & Biomedical Imaging
- Radiology Diversity Program
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Ventures
Education & Training
- PhD
- Yale University, Chemistry (1995)
- BA
- Wabash College, Chemistry (1990)
- Research Fellow (with Tuan Vo-Dinh)
- Oak Ridge National Laboratory, Oak Ridge, TN
- Research Fellow (with Robert G. Bryant)
- University of Rochester
- Post-Doctoral Associate (with Douglas L. Rothman)
- Yale University
- Associate Research Scientist
- Yale University
Research
Academic Achievements and Community Involvement
Links & Media
Media
fh - YDR website information (reserach images) 2014 - 1'
Because the burden of misdiagnosed brain disorders and diseases is substantial, the Hyder lab is leading breakthroughs in quantitative and translational imaging technologies, based primarily on magnetic resonance methods, to visualize molecular processes of function and dysfunction at the laminar level of the mammalian brain.fh - YDR website information (reserach images) 2014 - 2'
High resolution functional imaging. In vivo examples of fMRI for different rodent sensory models, where the colored voxels overlaid on top of the gray anatomy reflect sensory-induced function revealed by BOLD contrast. Courtesy of Basavaraju G. Sanganahalli and Christopher J. Bailey.fh - YDR website information (reserach images) 2014 - 3'
High resolution anatomical imaging. In vivo example of high resolution DTI in rodent brain, where the yellow, pink, and green colors represent respective directional dominance of fractional anisotropy of water diffusion to reflect tissue microstructure. Courtesy of Daniel Coman and Basavaraju G. Sanganahalli.fh - YDR website information (reserach images) 2014 - 4
High resolution molecular imaging. Based on a platform of an ultra-fast chemical shift imaging method called BIRDS, where we detect paramagnetically-shifted non-exchangeable protons from chelated lanthanide (or transition) metal ion probes, examples of high resolution temperature maps in rodent brain are shown. Data from Coman et al (2013) NMR Biomed. 26:1589-1595.fh - YDR website information (reserach images) 2014 - 5a
High resolution optical imaging of blood rheology. In vivo examples of laser speckle contrast leading to RBC velocity in rodent brain. The RBC velocity data are used to measure the rheological properties of BOLD contrast. Courtesy of Peter Herman.fh - YDR website information (reserach images) 2014 - 5b
High resolution electrical imaging of local field potential (LFP) and multi-unit activity (MUA). In vivo example of a 6x6 electrode array recording of MUA and LFP in rodent brain during sensory stimulation. The arrows reveal spatial uncoupling between MUA and LFP which has relevance for physiological interpretation of BOLD contrast. Courtesy of Peter Herman.
News
- October 12, 2021
ADPKD is Reversible in Preclinical Models, Finds New Yale Study
- March 06, 2021Source: Yale News
Yale study finds that when smelling, oral stimuli are weaker than nasal stimuli
- February 11, 2021Source: YaleNews
Taste and Its Two Ways to the Brain
- September 11, 2019
Prof. Hyder Joins Interdisciplinary Team to Assess Stroke Treatments