Yale-led study finds surprise link between metabolism and immunity
In the search for obesity treatments, scientists recently zeroed in on a gene known as Nucleobindin-2 (Nucb2), which was believed to play a role in satiety. However, in a new study published in Cell Reports, Yale researchers uncovered an unexpected function for the gene in reducing inflammation.
Battling belly fat: Specialized immune cells impair metabolism in aging
In a new study, Yale researchers have described how nervous systems and immune systems talk to each other to control metabolism and inflammation. Their finding furthers scientists’ understanding of why older adults fail to burn stored belly fat, which raises the risk of chronic disease. The study also points to potential therapeutic approaches to target the problem, the researchers said.
Could a ketogenic diet alleviate gout?
More than 8 million individuals in the United States have gout, a disease that can cause intense recurrent episodes of debilitating pain, inflammation, and fever. The cause of gout is the accumulation of urate crystals in joints, which continuously reactivate the immune system, leading to activation of the most common type of immune cell in the blood, neutrophils. These periods of immune reactivation are known as flares, and are driven by a protein complex called the NLRP3 inflammasome.
Constipated? Study finds surprising cause
A Yale-led study has shown a surprising link between constipation and herpes infection. The finding, published June 8 in Cell Host & Microbe, advances the science on herpes, and could help patients with chronic gastrointestinal diseases with no clear cause.
Eleven young investigators receive grants to pursue brain and behavior research
Eleven Yale investigators have received Young Investigator Grants from the Brain & Behavior Research Foundation (formerly NARSAD). The grants are among $12 million in new funding intended to lead to breakthroughs in understanding and treating mental illness.
YSM Human Subjects Research Guidance Regarding COVID-19 (Novel Coronavirus) Pandemic
Our top priority remains the safety of our research participants, patients, staff, and faculty. We continue to monitor events to determine what actions are required to keep everyone safe and informed. As the university remains open, the HRPP and YCCI continuity plan for COVID 19 as of today will be to continue normal operations of administrative functions and clinical research resources unless a change is deemed necessary. Both offices will be staffed through a combination of social distancing, rotating schedules, and working remotely from home.
Update on Human Research during COVID-19
We are updating the policy and guidelines recently distributed for modification to our procedures for conducting human subject research at the School of Medicine due to the COVID-19 pandemic. This addendum to the guidelines does not change any underlying policies but updates procedures for the implementation of those policies. It recognizes the existence of several categories of research protocols that require different responses to accomplish our continuing goals. Our primary concern is the safety of our research participants and the research team members who work for YSM and the health system.
Addendum 03/16/2020 21:00 h
As we make decisions on how to respond to the COVID-19 infections we want to begin by re-stating that our primary concern is the safety of our research participants and the research team members who work for YSM and the Health System. Our secondary goal is to preserve the scientific integrity of the research protocols.
Guidance on Conduct of Human Research during COVID-19
We write to inform you of current policy and guidelines for modifications to our procedures for conducting human subject research at the School of Medicine due to the COVID-19 pandemic. These include modifications as well as information on what needs to be reported to the IRB.
Yale Scientists Awarded $8.4M Grant to Develop Treatments for Women With Problem Drinking
Yale Department of Psychiatry scientists have been awarded a five-year, $8.4 million federal grant to establish a new research center at Yale that will develop treatments to help women with problem drinking.
Less Leaflet Thrombosis in Low-Risk TAVR Patients Treated With Oral Anticoagulation
Oral anticoagulation with warfarin after TAVR in patients with severe, symptomatic aortic stenosis at low risk for surgery appears to provide early protection against subclinical thrombosis and does so without increasing the risk of bleeding or vascular complications, according to the results of a small study presented this week at CRT 2020.Source: TCTMD
Yale Genomics Study: Helping Researchers Better Understand the Opioid Epidemic
A human genomics study led by two Yale Department of Psychiatry researchers identified specific genetic regions that link opioid exposure and dependence to neuropsychiatric traits like risk-taking behaviors, alcohol abuse, and depression.
Grilo Guest Co-Editor on Special Issue of American Psychologist
Carlos Grilo, PhD, Professor of Psychiatry and of Psychology and Director of the Yale Program for Obesity Weight and Eating Research, served as guest co-editor on a special issue titled "Obesity: Psychosocial and Behavioral Aspects of a Modern Epidemic" in the February/March issue of the American Psychologist, the official peer-reviewed scholarly journal of the American Psychological Association.
Yale School of Medicine Maintains its High National Ranking in Federal Research Funding
The 2019 total, $451,476,354, continues the school’s position in the top ten among U.S. medical schools that it has maintained each year since 2001. YSM ranked first in funding for psychiatry and dermatology; third for public health/preventive medicine and emergency medicine; fifth for radiology; sixth for neurology and ob-gyn; seventh for neurosurgery; and ninth for biochemistry, genetics, and internal medicine.